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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2005 Volume 26 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2005 Volume 26 Issue 2

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Article

Significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins in patients with hepatocellular carcinoma

  • Authors:
    • Takashi Himoto
    • Shigeki Kuriyama
    • Jian-Ying Zhang
    • Edward K.L. Chan
    • Mikio Nishioka
    • Eng M. Tan

  • View Affiliations / Copyright

    Affiliations: W.M. Keck Autoimmune Disease Center, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
  • Pages: 311-317
    |
    Published online on: February 1, 2005
       https://doi.org/10.3892/ijo.26.2.311
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Abstract

Autoantibodies against insulin-like growth factor II mRNA-binding proteins (IMPs) were analyzed in patients with hepatocellular carcinoma (HCC) to elucidate the significance of these autoantibodies. Five of 86 (5.8%) HCC patients had one or more of these autoantibodies. Serum α-fetoprotein (AFP) levels ranged within normal limits in HCC patients seropositive for anti-IMPs except for one case. One of HCC patients had anti-IMP1 and anti-IMP3 before the diagnosis of HCC. On the other hand, overexpressions of IMP1 and IMP2 in the tumor tissues were observed in 2 (28.6%) and 3 (42.9%) of 7 HCC tissues, respectively. One HCC patient with IMP1/2-overexpression in the tumor tissue had anti-IMP1/2, while the other HCC patients with overexpressions of IMP1/2 in the tumors did not have anti-IMP1/2. These findings may suggest that autoantibodies against IMPs are produced in an antigen-driven immune system and that anti-IMPs seem to be supplementary serological markers for the diagnosis of HCC in AFP-negative cases or predictive markers of HCC.

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Copy and paste a formatted citation
Spandidos Publications style
Himoto T, Kuriyama S, Zhang J, Chan EK, Nishioka M and Tan EM: Significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins in patients with hepatocellular carcinoma. Int J Oncol 26: 311-317, 2005.
APA
Himoto, T., Kuriyama, S., Zhang, J., Chan, E.K., Nishioka, M., & Tan, E.M. (2005). Significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins in patients with hepatocellular carcinoma. International Journal of Oncology, 26, 311-317. https://doi.org/10.3892/ijo.26.2.311
MLA
Himoto, T., Kuriyama, S., Zhang, J., Chan, E. K., Nishioka, M., Tan, E. M."Significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins in patients with hepatocellular carcinoma". International Journal of Oncology 26.2 (2005): 311-317.
Chicago
Himoto, T., Kuriyama, S., Zhang, J., Chan, E. K., Nishioka, M., Tan, E. M."Significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins in patients with hepatocellular carcinoma". International Journal of Oncology 26, no. 2 (2005): 311-317. https://doi.org/10.3892/ijo.26.2.311
Copy and paste a formatted citation
x
Spandidos Publications style
Himoto T, Kuriyama S, Zhang J, Chan EK, Nishioka M and Tan EM: Significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins in patients with hepatocellular carcinoma. Int J Oncol 26: 311-317, 2005.
APA
Himoto, T., Kuriyama, S., Zhang, J., Chan, E.K., Nishioka, M., & Tan, E.M. (2005). Significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins in patients with hepatocellular carcinoma. International Journal of Oncology, 26, 311-317. https://doi.org/10.3892/ijo.26.2.311
MLA
Himoto, T., Kuriyama, S., Zhang, J., Chan, E. K., Nishioka, M., Tan, E. M."Significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins in patients with hepatocellular carcinoma". International Journal of Oncology 26.2 (2005): 311-317.
Chicago
Himoto, T., Kuriyama, S., Zhang, J., Chan, E. K., Nishioka, M., Tan, E. M."Significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins in patients with hepatocellular carcinoma". International Journal of Oncology 26, no. 2 (2005): 311-317. https://doi.org/10.3892/ijo.26.2.311
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