Significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins in patients with hepatocellular carcinoma

  • Authors:
    • Takashi Himoto
    • Shigeki Kuriyama
    • Jian-Ying Zhang
    • Edward K.L. Chan
    • Mikio Nishioka
    • Eng M. Tan
  • View Affiliations

  • Published online on: February 1, 2005     https://doi.org/10.3892/ijo.26.2.311
  • Pages: 311-317
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Abstract

Autoantibodies against insulin-like growth factor II mRNA-binding proteins (IMPs) were analyzed in patients with hepatocellular carcinoma (HCC) to elucidate the significance of these autoantibodies. Five of 86 (5.8%) HCC patients had one or more of these autoantibodies. Serum α-fetoprotein (AFP) levels ranged within normal limits in HCC patients seropositive for anti-IMPs except for one case. One of HCC patients had anti-IMP1 and anti-IMP3 before the diagnosis of HCC. On the other hand, overexpressions of IMP1 and IMP2 in the tumor tissues were observed in 2 (28.6%) and 3 (42.9%) of 7 HCC tissues, respectively. One HCC patient with IMP1/2-overexpression in the tumor tissue had anti-IMP1/2, while the other HCC patients with overexpressions of IMP1/2 in the tumors did not have anti-IMP1/2. These findings may suggest that autoantibodies against IMPs are produced in an antigen-driven immune system and that anti-IMPs seem to be supplementary serological markers for the diagnosis of HCC in AFP-negative cases or predictive markers of HCC.

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February 2005
Volume 26 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Himoto T, Kuriyama S, Zhang J, Chan EK, Nishioka M and Tan EM: Significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins in patients with hepatocellular carcinoma. Int J Oncol 26: 311-317, 2005
APA
Himoto, T., Kuriyama, S., Zhang, J., Chan, E.K., Nishioka, M., & Tan, E.M. (2005). Significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins in patients with hepatocellular carcinoma. International Journal of Oncology, 26, 311-317. https://doi.org/10.3892/ijo.26.2.311
MLA
Himoto, T., Kuriyama, S., Zhang, J., Chan, E. K., Nishioka, M., Tan, E. M."Significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins in patients with hepatocellular carcinoma". International Journal of Oncology 26.2 (2005): 311-317.
Chicago
Himoto, T., Kuriyama, S., Zhang, J., Chan, E. K., Nishioka, M., Tan, E. M."Significance of autoantibodies against insulin-like growth factor II mRNA-binding proteins in patients with hepatocellular carcinoma". International Journal of Oncology 26, no. 2 (2005): 311-317. https://doi.org/10.3892/ijo.26.2.311