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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2005 Volume 26 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2005 Volume 26 Issue 2

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Article

COX-2 correlates with F-box protein, Skp2 expression and prognosis in human gastric carcinoma

  • Authors:
    • Soichiro Honjo
    • Satoru Kase
    • Mitsuhiko Osaki
    • Tonang Dwi Ardyanto
    • Nobuaki Kaibara
    • Hisao Ito

  • View Affiliations / Copyright

    Affiliations: Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University, Tottori 683-8503, Japan. honjo@grape.med.tottori-u.ac.jp
  • Pages: 353-360
    |
    Published online on: February 1, 2005
       https://doi.org/10.3892/ijo.26.2.353
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Abstract

The expression of cyclooxygenase (COX)-2 is induced by growth factors, tumor promoters and cytokines, and is correlated with carcinogenesis, tumor progression and inhibition of apoptosis. To clarify the pathological significance of COX-2, we examined the effect of a selective COX-2 inhibitor, NS398, on two human gastric carcinoma cell lines, MKN-45 and KATO-III, and the expression of Skp2, P27/Kip1 and COX-2 protein in human gastric carcinomas. NS398 inhibited cell growth in a time- and dose-dependent manner and exerted cell cycle arrest in the G0/G1 phase without induction of apoptosis in MKN-45, but had no effect in KATO-III. In MKN-45, NS398 induced up-regulation of P27/Kip1 and down-regulation of COX-2, cyclin D1 and Skp2. Immunohistochemistry using 63 surgically resected gastric carcinomas disclosed that COX-2 expression was correlated with Skp2 expression and that P27/Kip1 expression was inversely correlated with COX-2 and Skp2 expression. High levels of COX-2 or Skp2 were significantly correlated with poor survival (P=0.02 and P=0.004). Our results suggested that: a) NS398 induced inhibition of cell proliferation through cell cycle arrest and suppressed the expression of Skp2 in COX-2-expressing gastric carcinoma cells, and b) COX-2 contributes to the expression of Skp2 and poor survival in human gastric carcinomas.

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Copy and paste a formatted citation
Spandidos Publications style
Honjo S, Kase S, Osaki M, Ardyanto TD, Kaibara N and Ito H: COX-2 correlates with F-box protein, Skp2 expression and prognosis in human gastric carcinoma. Int J Oncol 26: 353-360, 2005.
APA
Honjo, S., Kase, S., Osaki, M., Ardyanto, T.D., Kaibara, N., & Ito, H. (2005). COX-2 correlates with F-box protein, Skp2 expression and prognosis in human gastric carcinoma. International Journal of Oncology, 26, 353-360. https://doi.org/10.3892/ijo.26.2.353
MLA
Honjo, S., Kase, S., Osaki, M., Ardyanto, T. D., Kaibara, N., Ito, H."COX-2 correlates with F-box protein, Skp2 expression and prognosis in human gastric carcinoma". International Journal of Oncology 26.2 (2005): 353-360.
Chicago
Honjo, S., Kase, S., Osaki, M., Ardyanto, T. D., Kaibara, N., Ito, H."COX-2 correlates with F-box protein, Skp2 expression and prognosis in human gastric carcinoma". International Journal of Oncology 26, no. 2 (2005): 353-360. https://doi.org/10.3892/ijo.26.2.353
Copy and paste a formatted citation
x
Spandidos Publications style
Honjo S, Kase S, Osaki M, Ardyanto TD, Kaibara N and Ito H: COX-2 correlates with F-box protein, Skp2 expression and prognosis in human gastric carcinoma. Int J Oncol 26: 353-360, 2005.
APA
Honjo, S., Kase, S., Osaki, M., Ardyanto, T.D., Kaibara, N., & Ito, H. (2005). COX-2 correlates with F-box protein, Skp2 expression and prognosis in human gastric carcinoma. International Journal of Oncology, 26, 353-360. https://doi.org/10.3892/ijo.26.2.353
MLA
Honjo, S., Kase, S., Osaki, M., Ardyanto, T. D., Kaibara, N., Ito, H."COX-2 correlates with F-box protein, Skp2 expression and prognosis in human gastric carcinoma". International Journal of Oncology 26.2 (2005): 353-360.
Chicago
Honjo, S., Kase, S., Osaki, M., Ardyanto, T. D., Kaibara, N., Ito, H."COX-2 correlates with F-box protein, Skp2 expression and prognosis in human gastric carcinoma". International Journal of Oncology 26, no. 2 (2005): 353-360. https://doi.org/10.3892/ijo.26.2.353
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