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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2005 Volume 26 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2005 Volume 26 Issue 2

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Article

Frequent trefoil factor 3 (TFF3) overexpression and promoter hypomethylation in mouse and human hepatocellular carcinomas

  • Authors:
    • Haruhiko Okada
    • Makoto T. Kimura
    • Dongfeng Tan
    • Kyoko Fujiwara
    • Jun Igarashi
    • Masatoshi Makuuchi
    • Ai-Min Hui
    • Masahiko Tsurumaru
    • Hiroki Nagase

  • View Affiliations / Copyright

    Affiliations: Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
  • Pages: 369-377
    |
    Published online on: February 1, 2005
       https://doi.org/10.3892/ijo.26.2.369
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Abstract

Expression profiling analysis revealed ectopic high expression of mouse TFF3 in non-tumor liver tissues from the hepatocellular carcinoma (HCC) susceptible PWK/Rbrc strain. TFF3 is a member of the trefoil factor family peptides, which are small secreted proteins regulating mucosal regeneration and repair, and which are overexpressed during inflammatory processes and cancer progression. We, therefore, analyzed the TFF3 expression extensively in mouse and human HCCs. Expression of the mouse TFF3 gene was significantly increased in 6 out of 7 HCCs from a PWK spontaneous tumor model and in all 7 HCCs from an SV40T antigen-induced transgenic MT-D2C57BL/6 model. In humans, 8 of 20 HCCs (40%) had overexpression of TFF3 in both mRNA level and protein level. We then analyzed DNA methylation patterns of the TFF3 promoter region to evaluate expression regulation of promoter methylation. In mouse HCCs, we demonstrated that two CpGs, at positions −992 and +109, were hypomethylated in 13 of 14 mouse HCCs. In human HCCs, hypomethylation at CpG −260 was associated with TFF3 overexpression (p=0.04). These results indicate that TFF3 overexpression may be a critical process in mouse and human hepatocellular carcinogenesis, and the specific promoter CpG hypomethylation may be one of the regulation mechanisms of TFF3 overexpression in HCCs.

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Copy and paste a formatted citation
Spandidos Publications style
Okada H, Kimura MT, Tan D, Fujiwara K, Igarashi J, Makuuchi M, Hui A, Tsurumaru M and Nagase H: Frequent trefoil factor 3 (TFF3) overexpression and promoter hypomethylation in mouse and human hepatocellular carcinomas. Int J Oncol 26: 369-377, 2005.
APA
Okada, H., Kimura, M.T., Tan, D., Fujiwara, K., Igarashi, J., Makuuchi, M. ... Nagase, H. (2005). Frequent trefoil factor 3 (TFF3) overexpression and promoter hypomethylation in mouse and human hepatocellular carcinomas. International Journal of Oncology, 26, 369-377. https://doi.org/10.3892/ijo.26.2.369
MLA
Okada, H., Kimura, M. T., Tan, D., Fujiwara, K., Igarashi, J., Makuuchi, M., Hui, A., Tsurumaru, M., Nagase, H."Frequent trefoil factor 3 (TFF3) overexpression and promoter hypomethylation in mouse and human hepatocellular carcinomas". International Journal of Oncology 26.2 (2005): 369-377.
Chicago
Okada, H., Kimura, M. T., Tan, D., Fujiwara, K., Igarashi, J., Makuuchi, M., Hui, A., Tsurumaru, M., Nagase, H."Frequent trefoil factor 3 (TFF3) overexpression and promoter hypomethylation in mouse and human hepatocellular carcinomas". International Journal of Oncology 26, no. 2 (2005): 369-377. https://doi.org/10.3892/ijo.26.2.369
Copy and paste a formatted citation
x
Spandidos Publications style
Okada H, Kimura MT, Tan D, Fujiwara K, Igarashi J, Makuuchi M, Hui A, Tsurumaru M and Nagase H: Frequent trefoil factor 3 (TFF3) overexpression and promoter hypomethylation in mouse and human hepatocellular carcinomas. Int J Oncol 26: 369-377, 2005.
APA
Okada, H., Kimura, M.T., Tan, D., Fujiwara, K., Igarashi, J., Makuuchi, M. ... Nagase, H. (2005). Frequent trefoil factor 3 (TFF3) overexpression and promoter hypomethylation in mouse and human hepatocellular carcinomas. International Journal of Oncology, 26, 369-377. https://doi.org/10.3892/ijo.26.2.369
MLA
Okada, H., Kimura, M. T., Tan, D., Fujiwara, K., Igarashi, J., Makuuchi, M., Hui, A., Tsurumaru, M., Nagase, H."Frequent trefoil factor 3 (TFF3) overexpression and promoter hypomethylation in mouse and human hepatocellular carcinomas". International Journal of Oncology 26.2 (2005): 369-377.
Chicago
Okada, H., Kimura, M. T., Tan, D., Fujiwara, K., Igarashi, J., Makuuchi, M., Hui, A., Tsurumaru, M., Nagase, H."Frequent trefoil factor 3 (TFF3) overexpression and promoter hypomethylation in mouse and human hepatocellular carcinomas". International Journal of Oncology 26, no. 2 (2005): 369-377. https://doi.org/10.3892/ijo.26.2.369
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