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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2005 Volume 26 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2005 Volume 26 Issue 2

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Article

BRD-glucan exhibits potent immunochemotherapeutic activity in vitro and in vivo

  • Authors:
    • Seong-Hoon Moon
    • Jin-Chul Heo
    • Robert L. Fine
    • Hwan-Mook Kim
    • Sung-Uk Kim
    • Byung-Dae Yoon
    • Sang-Han Lee

  • View Affiliations / Copyright

    Affiliations: Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon 305-333, Korea
  • Pages: 395-404
    |
    Published online on: February 1, 2005
       https://doi.org/10.3892/ijo.26.2.395
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Abstract

We carried out in vitro and in vivo assays to investigate the immunomodulatory and immunochemotherapeutic action mechanism of BRD-glucan, a high molecular weight (≈3,500 kDa) polysaccharide isolated from Aureobasidium sp, and assessed the efficacy of BRD-glucan/adriamycin co-treatment of animal cancer models. RT-PCR and suspension hemolytic, plaque forming, wounding, invasion and cell proliferation assays were utilized to investigate the in vitro immunochemotherapeutic effects of BRD-glucan. In vivo, the effects of BRD-glucan and BRD-glucan/adriamycin co-treatment were tested in a B16 melanoma initiation model and in C57BL/6 mice. In vitro, BRD-glucan did not affect the cellular wounding response or invasion activity; treatment with BRD-glucan led to increase proliferation of B cells, natural killer cells and macrophages, but not T cells. In addition, we found that the BRD-glucan activation of B cells and macrophages was dependent on Toll-like receptor2 (TLR2) and TLR4, which play important roles in innate and adaptive immunity. In vivo, BRD-glucan/adriamycin co-treatment effectively reduced the number and size of metastatic colonies. Based on the results of our in vitro and in vivo toxicity, safety and immunochemotherapy assays, we propose that BRD-glucan is a promising immunochemotherapeutic anti-tumor agent.

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Copy and paste a formatted citation
Spandidos Publications style
Moon S, Heo J, Fine RL, Kim H, Kim S, Yoon B and Lee S: BRD-glucan exhibits potent immunochemotherapeutic activity in vitro and in vivo. Int J Oncol 26: 395-404, 2005.
APA
Moon, S., Heo, J., Fine, R.L., Kim, H., Kim, S., Yoon, B., & Lee, S. (2005). BRD-glucan exhibits potent immunochemotherapeutic activity in vitro and in vivo. International Journal of Oncology, 26, 395-404. https://doi.org/10.3892/ijo.26.2.395
MLA
Moon, S., Heo, J., Fine, R. L., Kim, H., Kim, S., Yoon, B., Lee, S."BRD-glucan exhibits potent immunochemotherapeutic activity in vitro and in vivo". International Journal of Oncology 26.2 (2005): 395-404.
Chicago
Moon, S., Heo, J., Fine, R. L., Kim, H., Kim, S., Yoon, B., Lee, S."BRD-glucan exhibits potent immunochemotherapeutic activity in vitro and in vivo". International Journal of Oncology 26, no. 2 (2005): 395-404. https://doi.org/10.3892/ijo.26.2.395
Copy and paste a formatted citation
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Spandidos Publications style
Moon S, Heo J, Fine RL, Kim H, Kim S, Yoon B and Lee S: BRD-glucan exhibits potent immunochemotherapeutic activity in vitro and in vivo. Int J Oncol 26: 395-404, 2005.
APA
Moon, S., Heo, J., Fine, R.L., Kim, H., Kim, S., Yoon, B., & Lee, S. (2005). BRD-glucan exhibits potent immunochemotherapeutic activity in vitro and in vivo. International Journal of Oncology, 26, 395-404. https://doi.org/10.3892/ijo.26.2.395
MLA
Moon, S., Heo, J., Fine, R. L., Kim, H., Kim, S., Yoon, B., Lee, S."BRD-glucan exhibits potent immunochemotherapeutic activity in vitro and in vivo". International Journal of Oncology 26.2 (2005): 395-404.
Chicago
Moon, S., Heo, J., Fine, R. L., Kim, H., Kim, S., Yoon, B., Lee, S."BRD-glucan exhibits potent immunochemotherapeutic activity in vitro and in vivo". International Journal of Oncology 26, no. 2 (2005): 395-404. https://doi.org/10.3892/ijo.26.2.395
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