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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2005 Volume 26 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2005 Volume 26 Issue 3

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Article

IL-4 and IL-10 synergistically inhibit survival of human blood monocytes supported by GM-CSF

  • Authors:
    • Hiroyuki Miyashita
    • Naoyuki Katayama
    • Atsushi Fujieda
    • Tetsunori Shibasaki
    • Kentaro Yamamura
    • Yuka Sugimoto
    • Eri Miyata
    • Kohshi Ohishi
    • Kazuhiro Nishii
    • Masahiro Masuya
    • Hiroshi Shiku

  • View Affiliations / Copyright

    Affiliations: Second Department of Internal Medicine, Mie University School of Medicine, Mie 514-8507, Japan
  • Pages: 731-735
    |
    Published online on: March 1, 2005
       https://doi.org/10.3892/ijo.26.3.731
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Abstract

Interleukin (IL)-4 and IL-10 have a wide variety of activities in the immune system. We re-evaluated the action of IL-4 and IL-10 on human blood monocytes, myeloid dendritic cell (DC1) precursors, using a serum-free culture system. Both IL-4 and IL-10 inhibited the survival of CD14+ monocytes supported by granulocyte-macrophage colony-stimulating factor in a dose-dependent manner. When IL-4 and IL-10 were combined, they had synergistic effects at low doses and induced a profound suppression of CD14+ monocyte survival. When the optimal timing was determined, the exposure to IL-4 and IL-10 for the initial 2 days was essential for suppression of survival of CD14+ monocytes. Annexin V/propidium iodide staining indicates that the suppression of CD14+ monocyte survival induced by IL-4 and IL-10 results from apoptosis. Tumor necrosis factor-α and lipopolysaccharide abrogated the effects of IL-4 and IL-10 on CD14+ monocytes, albeit incompletely. Thus, IL-4 in synergy with IL-10 negatively regulates the survival of DC1 precursor monocytes by inducing their apoptosis, which is modulated by factors such as tumor necrosis factor-α and lipopolysaccharide. Our data suggest the primary activities of IL-4 and IL-10 in DC1-mediated immune responses.

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Copy and paste a formatted citation
Spandidos Publications style
Miyashita H, Katayama N, Fujieda A, Shibasaki T, Yamamura K, Sugimoto Y, Miyata E, Ohishi K, Nishii K, Masuya M, Masuya M, et al: IL-4 and IL-10 synergistically inhibit survival of human blood monocytes supported by GM-CSF. Int J Oncol 26: 731-735, 2005.
APA
Miyashita, H., Katayama, N., Fujieda, A., Shibasaki, T., Yamamura, K., Sugimoto, Y. ... Shiku, H. (2005). IL-4 and IL-10 synergistically inhibit survival of human blood monocytes supported by GM-CSF. International Journal of Oncology, 26, 731-735. https://doi.org/10.3892/ijo.26.3.731
MLA
Miyashita, H., Katayama, N., Fujieda, A., Shibasaki, T., Yamamura, K., Sugimoto, Y., Miyata, E., Ohishi, K., Nishii, K., Masuya, M., Shiku, H."IL-4 and IL-10 synergistically inhibit survival of human blood monocytes supported by GM-CSF". International Journal of Oncology 26.3 (2005): 731-735.
Chicago
Miyashita, H., Katayama, N., Fujieda, A., Shibasaki, T., Yamamura, K., Sugimoto, Y., Miyata, E., Ohishi, K., Nishii, K., Masuya, M., Shiku, H."IL-4 and IL-10 synergistically inhibit survival of human blood monocytes supported by GM-CSF". International Journal of Oncology 26, no. 3 (2005): 731-735. https://doi.org/10.3892/ijo.26.3.731
Copy and paste a formatted citation
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Spandidos Publications style
Miyashita H, Katayama N, Fujieda A, Shibasaki T, Yamamura K, Sugimoto Y, Miyata E, Ohishi K, Nishii K, Masuya M, Masuya M, et al: IL-4 and IL-10 synergistically inhibit survival of human blood monocytes supported by GM-CSF. Int J Oncol 26: 731-735, 2005.
APA
Miyashita, H., Katayama, N., Fujieda, A., Shibasaki, T., Yamamura, K., Sugimoto, Y. ... Shiku, H. (2005). IL-4 and IL-10 synergistically inhibit survival of human blood monocytes supported by GM-CSF. International Journal of Oncology, 26, 731-735. https://doi.org/10.3892/ijo.26.3.731
MLA
Miyashita, H., Katayama, N., Fujieda, A., Shibasaki, T., Yamamura, K., Sugimoto, Y., Miyata, E., Ohishi, K., Nishii, K., Masuya, M., Shiku, H."IL-4 and IL-10 synergistically inhibit survival of human blood monocytes supported by GM-CSF". International Journal of Oncology 26.3 (2005): 731-735.
Chicago
Miyashita, H., Katayama, N., Fujieda, A., Shibasaki, T., Yamamura, K., Sugimoto, Y., Miyata, E., Ohishi, K., Nishii, K., Masuya, M., Shiku, H."IL-4 and IL-10 synergistically inhibit survival of human blood monocytes supported by GM-CSF". International Journal of Oncology 26, no. 3 (2005): 731-735. https://doi.org/10.3892/ijo.26.3.731
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