Localised non-Hodgkin lymphoma of the testis: The Sheffield Lymphoma Group experience

  • Authors:
    • Suzanne Darby
    • Barry W. Hancock
  • View Affiliations

  • Published online on: April 1, 2005     https://doi.org/10.3892/ijo.26.4.1093
  • Pages: 1093-1099
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Abstract

We evaluated clinical features, management and survival of patients with localised (stage 1E or 2E) testicular non-Hodgkin lymphoma (NHL) presenting to the Sheffield Lymphoma Group between 1972 and 2002. Thirty consecutive eligible patients were identified from the lymphoma database and clinical records of all were reviewed. Survival data were statistically analysed. The median age of patients was 74 years (range 38-87). Sixty-three percent were >70 years of age. The median duration of follow-up was 15 months (range 2.1-211). All patients had orchidectomy. Eleven (37%) had orchidectomy alone. Twelve (40%) had orchidectomy and chemotherapy, 4 (13%) had orchidectomy and radiotherapy. Three (10%) had orchidectomy, chemotherapy and radio-therapy. Five (17%) had immediate disease progression following orchidectomy or whilst on treatment. A complete response was seen in the remaining 25 (84%) irrespective of treatment modality. Seven (23%) of patients remain alive, with a median follow-up of 73 months (range 9.9-211). Six (20%) died of causes not related to their lymphoma. Twelve (40%) relapsed following a complete response and median time to relapse was 9 months. Only 1 of these relapses was in the central nervous system; 1 in bone, 1 in skin, 2 in the contralateral testis. The majority of relapses (58%) occurred in the lymph nodes. Primary testicular lymphoma is an uncommon and poor prognosis disease usually affecting older men. The data and experience available to guide the treatment strategies for testicular lymphoma are limited. However, the evidence points to a combined modality approach being the most likely effective treatment, comprising surgery, anthracycline-containing combination chemotherapy with or without prophylactic contralateral testis and regional lymph node irradiation.

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April 2005
Volume 26 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Darby S and Darby S: Localised non-Hodgkin lymphoma of the testis: The Sheffield Lymphoma Group experience. Int J Oncol 26: 1093-1099, 2005
APA
Darby, S., & Darby, S. (2005). Localised non-Hodgkin lymphoma of the testis: The Sheffield Lymphoma Group experience. International Journal of Oncology, 26, 1093-1099. https://doi.org/10.3892/ijo.26.4.1093
MLA
Darby, S., Hancock, B. W."Localised non-Hodgkin lymphoma of the testis: The Sheffield Lymphoma Group experience". International Journal of Oncology 26.4 (2005): 1093-1099.
Chicago
Darby, S., Hancock, B. W."Localised non-Hodgkin lymphoma of the testis: The Sheffield Lymphoma Group experience". International Journal of Oncology 26, no. 4 (2005): 1093-1099. https://doi.org/10.3892/ijo.26.4.1093