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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2005 Volume 26 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2005 Volume 26 Issue 6

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Article

Apoptosis and differentiation induced by staurosporine in granulosa tumor cells is coupled with activation of JNK and suppression of p38 MAPK

  • Authors:
    • Hong Zhang
    • Marielle Vollmer
    • Maria De Geyter
    • Markus Dürrenberger
    • Christian De Geyter

  • View Affiliations / Copyright

    Affiliations: Department of Research and University Women's Hospital Basel, CH-4031 Basel, Switzerland
  • Pages: 1575-1580
    |
    Published online on: June 1, 2005
       https://doi.org/10.3892/ijo.26.6.1575
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Abstract

We report here that staurosporine can induce apoptosis or differentiation of granulosa tumor cells depending on its dosage. In presence of staurosporine concentrations >50 nM, apoptosis was triggered in human granulosa cell tumor cells COV434. In the presence of concentrations <50 nM, the shape of the otherwise globular granulosa cells differentiated into a flattened epithelioid-like appearance. The process was associated by the induction of prostaglandin synthase-2 (PGS-2) and C/EBPβ expression and by an increase in progesterone production in the supernatant culture medium. The observed effects of staurosporine were synergized by forskolin. With phosphorylation-specific Western blotting and protein kinase assays, it was demonstrated that staurosporine suppresses the phosphorylation of p38 and activates JNK. These results suggest that p38MAPK and JNK signal transduction pathways were involved in the regulation of granulosa cell differentiation by staurosporine. These results may indicate the usefulness of staurosporine or its analogs for the development of a future medical treatment of granulosa tumors.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang H, Vollmer M, De Geyter M, Dürrenberger M and De Geyter C: Apoptosis and differentiation induced by staurosporine in granulosa tumor cells is coupled with activation of JNK and suppression of p38 MAPK. Int J Oncol 26: 1575-1580, 2005.
APA
Zhang, H., Vollmer, M., De Geyter, M., Dürrenberger, M., & De Geyter, C. (2005). Apoptosis and differentiation induced by staurosporine in granulosa tumor cells is coupled with activation of JNK and suppression of p38 MAPK. International Journal of Oncology, 26, 1575-1580. https://doi.org/10.3892/ijo.26.6.1575
MLA
Zhang, H., Vollmer, M., De Geyter, M., Dürrenberger, M., De Geyter, C."Apoptosis and differentiation induced by staurosporine in granulosa tumor cells is coupled with activation of JNK and suppression of p38 MAPK". International Journal of Oncology 26.6 (2005): 1575-1580.
Chicago
Zhang, H., Vollmer, M., De Geyter, M., Dürrenberger, M., De Geyter, C."Apoptosis and differentiation induced by staurosporine in granulosa tumor cells is coupled with activation of JNK and suppression of p38 MAPK". International Journal of Oncology 26, no. 6 (2005): 1575-1580. https://doi.org/10.3892/ijo.26.6.1575
Copy and paste a formatted citation
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Spandidos Publications style
Zhang H, Vollmer M, De Geyter M, Dürrenberger M and De Geyter C: Apoptosis and differentiation induced by staurosporine in granulosa tumor cells is coupled with activation of JNK and suppression of p38 MAPK. Int J Oncol 26: 1575-1580, 2005.
APA
Zhang, H., Vollmer, M., De Geyter, M., Dürrenberger, M., & De Geyter, C. (2005). Apoptosis and differentiation induced by staurosporine in granulosa tumor cells is coupled with activation of JNK and suppression of p38 MAPK. International Journal of Oncology, 26, 1575-1580. https://doi.org/10.3892/ijo.26.6.1575
MLA
Zhang, H., Vollmer, M., De Geyter, M., Dürrenberger, M., De Geyter, C."Apoptosis and differentiation induced by staurosporine in granulosa tumor cells is coupled with activation of JNK and suppression of p38 MAPK". International Journal of Oncology 26.6 (2005): 1575-1580.
Chicago
Zhang, H., Vollmer, M., De Geyter, M., Dürrenberger, M., De Geyter, C."Apoptosis and differentiation induced by staurosporine in granulosa tumor cells is coupled with activation of JNK and suppression of p38 MAPK". International Journal of Oncology 26, no. 6 (2005): 1575-1580. https://doi.org/10.3892/ijo.26.6.1575
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