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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2005 Volume 27 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2005 Volume 27 Issue 1

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Article

Expression and functional analyses of mHAUSP regulating apoptosis of cervical adenocarcinoma cells

  • Authors:
    • Kyong-Jai Yoo
    • Hye-Jin Lee
    • Heyjin Lee
    • Kwang-Youl Lee
    • Sook-Hwan Lee
    • Hyung-Min Chung
    • Kwang-Hyun Baek

  • View Affiliations / Copyright

    Affiliations: Graduate School of Life Science and Biotechnology, Seoul, Korea
  • Pages: 97-104
    |
    Published online on: July 1, 2005
       https://doi.org/10.3892/ijo.27.1.97
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Abstract

p53 tumor suppressor protein is stabilized by the herpes-virus-associated ubiquitin-specific protease (HAUSP), a deubiquitinating enzyme. We previously isolated a mouse orthologue of HAUSP, mHAUSP, encoding 1103 amino acids with a molecular weight of approximately 135 kDa containing highly conserved Cys, Asp (I), His, and Asn/Asp (II) domains. In this study, we investigated the temporal and spatial expression of mHAUSP during the early mouse embryonic development. Northern blot analysis revealed that the expression of mHAUSP was detected throughout the process of embryonic development with the maximal expression between E10.5 and E13.5. In situ hybridization study showed the global expression of mHAUSP in various organs of embryos, including mesencephalon, spinal cord, lung and genital eminence. In addition, we carried out biochemical analysis for 6 conserved amino acids (Cys224, Gln231, Asp296, His457, His465, and Asp482) in Cys box, QQD box, and His box in order to investigate their structural and functional roles of these amino acid residues. The conserved Gln231 was not essential for the catalytic activity of mHAUSP. However, other conserved amino acids were required for deubiquitinating enzyme activity of mHAUSP. Moreover, we observed that the overexpression of mHAUSP induces cell death in HeLa cells.

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Copy and paste a formatted citation
Spandidos Publications style
Yoo K, Lee H, Lee H, Lee K, Lee S, Chung H and Baek K: Expression and functional analyses of mHAUSP regulating apoptosis of cervical adenocarcinoma cells. Int J Oncol 27: 97-104, 2005.
APA
Yoo, K., Lee, H., Lee, H., Lee, K., Lee, S., Chung, H., & Baek, K. (2005). Expression and functional analyses of mHAUSP regulating apoptosis of cervical adenocarcinoma cells. International Journal of Oncology, 27, 97-104. https://doi.org/10.3892/ijo.27.1.97
MLA
Yoo, K., Lee, H., Lee, H., Lee, K., Lee, S., Chung, H., Baek, K."Expression and functional analyses of mHAUSP regulating apoptosis of cervical adenocarcinoma cells". International Journal of Oncology 27.1 (2005): 97-104.
Chicago
Yoo, K., Lee, H., Lee, H., Lee, K., Lee, S., Chung, H., Baek, K."Expression and functional analyses of mHAUSP regulating apoptosis of cervical adenocarcinoma cells". International Journal of Oncology 27, no. 1 (2005): 97-104. https://doi.org/10.3892/ijo.27.1.97
Copy and paste a formatted citation
x
Spandidos Publications style
Yoo K, Lee H, Lee H, Lee K, Lee S, Chung H and Baek K: Expression and functional analyses of mHAUSP regulating apoptosis of cervical adenocarcinoma cells. Int J Oncol 27: 97-104, 2005.
APA
Yoo, K., Lee, H., Lee, H., Lee, K., Lee, S., Chung, H., & Baek, K. (2005). Expression and functional analyses of mHAUSP regulating apoptosis of cervical adenocarcinoma cells. International Journal of Oncology, 27, 97-104. https://doi.org/10.3892/ijo.27.1.97
MLA
Yoo, K., Lee, H., Lee, H., Lee, K., Lee, S., Chung, H., Baek, K."Expression and functional analyses of mHAUSP regulating apoptosis of cervical adenocarcinoma cells". International Journal of Oncology 27.1 (2005): 97-104.
Chicago
Yoo, K., Lee, H., Lee, H., Lee, K., Lee, S., Chung, H., Baek, K."Expression and functional analyses of mHAUSP regulating apoptosis of cervical adenocarcinoma cells". International Journal of Oncology 27, no. 1 (2005): 97-104. https://doi.org/10.3892/ijo.27.1.97
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