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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2005 Volume 27 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2005 Volume 27 Issue 5

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Article

Neuropilin-1 and VEGF correlate with somatostatin expression and microvessel density in ovarian tumours

  • Authors:
    • Glen H. Hall
    • Lindsay W. Turnbull
    • Karen Bedford
    • Ian Richmond
    • Lone Helboe
    • Stephen L. Atkin

  • View Affiliations / Copyright

    Affiliations: Department of Radiology, University of Hull, Centre for Magnetic Resonance Investigations, Hull Royal Infirmary, Hull, HU3 2JZ, UK
  • Pages: 1283-1288
    |
    Published online on: November 1, 2005
       https://doi.org/10.3892/ijo.27.5.1283
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Abstract

Vascular endothelial growth factor (VEGF), is an angiogenic growth factor, expressed more highly in malignant than benign ovarian tumours. Neuropilin-1, which can act as a VEGF receptor has been shown to be associated with tumour angiogenesis in some cancer systems. Somatostatin (SST), a potentially anti-angiogenic factor, acts via somatostatin receptors that are expressed in ovarian cancer. We used immunohistochemistry to demonstrate expression of Neuropilin-1 in 63 malignant and 35 benign ovarian tumours and compared it to VEGF, Flt, Flk, SST expression and tumour microvessel density (MVD). Neuropilin-1 was expressed in 34/63 malignant and 22/35 benign lesions. VEGF, Flt, Flk and SST were expressed more highly in the epithelium of malignant and the vessels of benign lesions. VEGF expression correlated with SST expression in the epithelium (p<0.001) and the vessels (p<0.001), this co-expression was confirmed by dual immunostaining. The MVD for malignant lesions was higher than benign (p<0.001) and positively correlated to epithelial VEGF expression (p=0.001) and negatively correlated to vascular VEGF expression (p=0.025). These results show that Neuropilin-1 is expressed in ovarian tumours and also show that VEGF and SST are co-expressed in the same tissue compartments raising the intriguing possibility that SST may be important in angiogenesis in ovarian cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Hall GH, Turnbull LW, Bedford K, Richmond I, Helboe L and Atkin SL: Neuropilin-1 and VEGF correlate with somatostatin expression and microvessel density in ovarian tumours. Int J Oncol 27: 1283-1288, 2005.
APA
Hall, G.H., Turnbull, L.W., Bedford, K., Richmond, I., Helboe, L., & Atkin, S.L. (2005). Neuropilin-1 and VEGF correlate with somatostatin expression and microvessel density in ovarian tumours. International Journal of Oncology, 27, 1283-1288. https://doi.org/10.3892/ijo.27.5.1283
MLA
Hall, G. H., Turnbull, L. W., Bedford, K., Richmond, I., Helboe, L., Atkin, S. L."Neuropilin-1 and VEGF correlate with somatostatin expression and microvessel density in ovarian tumours". International Journal of Oncology 27.5 (2005): 1283-1288.
Chicago
Hall, G. H., Turnbull, L. W., Bedford, K., Richmond, I., Helboe, L., Atkin, S. L."Neuropilin-1 and VEGF correlate with somatostatin expression and microvessel density in ovarian tumours". International Journal of Oncology 27, no. 5 (2005): 1283-1288. https://doi.org/10.3892/ijo.27.5.1283
Copy and paste a formatted citation
x
Spandidos Publications style
Hall GH, Turnbull LW, Bedford K, Richmond I, Helboe L and Atkin SL: Neuropilin-1 and VEGF correlate with somatostatin expression and microvessel density in ovarian tumours. Int J Oncol 27: 1283-1288, 2005.
APA
Hall, G.H., Turnbull, L.W., Bedford, K., Richmond, I., Helboe, L., & Atkin, S.L. (2005). Neuropilin-1 and VEGF correlate with somatostatin expression and microvessel density in ovarian tumours. International Journal of Oncology, 27, 1283-1288. https://doi.org/10.3892/ijo.27.5.1283
MLA
Hall, G. H., Turnbull, L. W., Bedford, K., Richmond, I., Helboe, L., Atkin, S. L."Neuropilin-1 and VEGF correlate with somatostatin expression and microvessel density in ovarian tumours". International Journal of Oncology 27.5 (2005): 1283-1288.
Chicago
Hall, G. H., Turnbull, L. W., Bedford, K., Richmond, I., Helboe, L., Atkin, S. L."Neuropilin-1 and VEGF correlate with somatostatin expression and microvessel density in ovarian tumours". International Journal of Oncology 27, no. 5 (2005): 1283-1288. https://doi.org/10.3892/ijo.27.5.1283
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