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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2005 Volume 27 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2005 Volume 27 Issue 6

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Article

Identification of SP5 as a downstream gene of the β-catenin/Tcf pathway and its enhanced expression in human colon cancer

  • Authors:
    • Meiko Takahashi
    • Yusuke Nakamura
    • Kazutaka Obama
    • Yoichi Furukawa

  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Medicine, The University of Tokyo, Minato-ku, Tokyo, Japan
  • Pages: 1483-1487
    |
    Published online on: December 1, 2005
       https://doi.org/10.3892/ijo.27.6.1483
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Abstract

Mutations in APC, CTNNB1, AXIN1 or AXIN2 cause impairment in the β-catenin degradation pathway and result in accumulation of β-catenin in a wide range of human cancers. Accumulated β-catenin then associates with Tcf/LEF transcription factors and transactivates their target genes. To uncover in detail the role of accumulated β-catenin in colorectal carcinogenesis, we searched for genes involved in the β-catenin/Tcf signaling pathway by cDNA microarray. We identified and characterized a human gene, SP5, that was down-regulated after depletion of β-catenin by transduction of wild-type APC into SW480 cells. SP5 is a member of the Sp transcription factor family, which binds to the GC box or closely related sequences in promoters of many genes and control their expression. Reporter assays and an electromobility-shift assay revealed a DNA fragment between −285 and −279 in the 5' flanking region of this gene to be a target of the β-catenin/Tcf4 complex. Our results indicate that SP5 is a novel direct down-stream target in the Wnt signaling pathway.

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Copy and paste a formatted citation
Spandidos Publications style
Takahashi M, Nakamura Y, Obama K and Furukawa Y: Identification of SP5 as a downstream gene of the β-catenin/Tcf pathway and its enhanced expression in human colon cancer. Int J Oncol 27: 1483-1487, 2005.
APA
Takahashi, M., Nakamura, Y., Obama, K., & Furukawa, Y. (2005). Identification of SP5 as a downstream gene of the β-catenin/Tcf pathway and its enhanced expression in human colon cancer. International Journal of Oncology, 27, 1483-1487. https://doi.org/10.3892/ijo.27.6.1483
MLA
Takahashi, M., Nakamura, Y., Obama, K., Furukawa, Y."Identification of SP5 as a downstream gene of the β-catenin/Tcf pathway and its enhanced expression in human colon cancer". International Journal of Oncology 27.6 (2005): 1483-1487.
Chicago
Takahashi, M., Nakamura, Y., Obama, K., Furukawa, Y."Identification of SP5 as a downstream gene of the β-catenin/Tcf pathway and its enhanced expression in human colon cancer". International Journal of Oncology 27, no. 6 (2005): 1483-1487. https://doi.org/10.3892/ijo.27.6.1483
Copy and paste a formatted citation
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Spandidos Publications style
Takahashi M, Nakamura Y, Obama K and Furukawa Y: Identification of SP5 as a downstream gene of the β-catenin/Tcf pathway and its enhanced expression in human colon cancer. Int J Oncol 27: 1483-1487, 2005.
APA
Takahashi, M., Nakamura, Y., Obama, K., & Furukawa, Y. (2005). Identification of SP5 as a downstream gene of the β-catenin/Tcf pathway and its enhanced expression in human colon cancer. International Journal of Oncology, 27, 1483-1487. https://doi.org/10.3892/ijo.27.6.1483
MLA
Takahashi, M., Nakamura, Y., Obama, K., Furukawa, Y."Identification of SP5 as a downstream gene of the β-catenin/Tcf pathway and its enhanced expression in human colon cancer". International Journal of Oncology 27.6 (2005): 1483-1487.
Chicago
Takahashi, M., Nakamura, Y., Obama, K., Furukawa, Y."Identification of SP5 as a downstream gene of the β-catenin/Tcf pathway and its enhanced expression in human colon cancer". International Journal of Oncology 27, no. 6 (2005): 1483-1487. https://doi.org/10.3892/ijo.27.6.1483
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