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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2005 Volume 27 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2005 Volume 27 Issue 6

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Article

Leptin and leptin receptor expression in the myometrium and uterine myomas: is leptin involved in tumor development?

  • Authors:
    • Anna Markowska
    • Anna Sandra Belloni
    • Marcin Rucinski
    • Anna R. Parenti
    • Giovan Battista Nardelli
    • Krzysztof Drews
    • Gastone G. Nussdorfer
    • Ludwik K. Malendowicz

  • View Affiliations / Copyright

    Affiliations: Department of Perinatology and Gynecology, Poznan University of Medical Sciences, PL-60781 Poznan, Poland
  • Pages: 1505-1509
    |
    Published online on: December 1, 2005
       https://doi.org/10.3892/ijo.27.6.1505
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Abstract

Leptin, the product of the obesity (ob) gene, along with its receptors (Ob-Rs), is expressed in several tissues and organs. Evidence has been provided that leptin, in addition to being involved in obesity development, plays a role in the regulation of the female reproductive system, angiogenesis and tumor growth. Uterine myoma is a rather common disease that develops more frequently in obese than lean women, where plasma leptin concentrations are elevated. RT-PCR and Western blotting showed that leptin was expressed, as mRNA and protein, in several uterine myomas but not in normal myometrium, while leptin receptors were expressed in both tissues. Immunocytochemistry indicated that leptin-immunoreactivity was located in both myometrial cells and blood-vessel walls of uterine myomas. Leptin(22-56), at concentrations of 10−7 and 10−6 M, enhanced the proliferative activity of both the normal myometrium and myoma cells in primary culture. Taken together, our findings allow us to suggest that leptin, acting through autocrine-paracrine mechanism(s), may be involved in the development of uterine myomas.

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Copy and paste a formatted citation
Spandidos Publications style
Markowska A, Belloni AS, Rucinski M, Parenti AR, Nardelli GB, Drews K, Nussdorfer GG and Malendowicz LK: Leptin and leptin receptor expression in the myometrium and uterine myomas: is leptin involved in tumor development?. Int J Oncol 27: 1505-1509, 2005.
APA
Markowska, A., Belloni, A.S., Rucinski, M., Parenti, A.R., Nardelli, G.B., Drews, K. ... Malendowicz, L.K. (2005). Leptin and leptin receptor expression in the myometrium and uterine myomas: is leptin involved in tumor development?. International Journal of Oncology, 27, 1505-1509. https://doi.org/10.3892/ijo.27.6.1505
MLA
Markowska, A., Belloni, A. S., Rucinski, M., Parenti, A. R., Nardelli, G. B., Drews, K., Nussdorfer, G. G., Malendowicz, L. K."Leptin and leptin receptor expression in the myometrium and uterine myomas: is leptin involved in tumor development?". International Journal of Oncology 27.6 (2005): 1505-1509.
Chicago
Markowska, A., Belloni, A. S., Rucinski, M., Parenti, A. R., Nardelli, G. B., Drews, K., Nussdorfer, G. G., Malendowicz, L. K."Leptin and leptin receptor expression in the myometrium and uterine myomas: is leptin involved in tumor development?". International Journal of Oncology 27, no. 6 (2005): 1505-1509. https://doi.org/10.3892/ijo.27.6.1505
Copy and paste a formatted citation
x
Spandidos Publications style
Markowska A, Belloni AS, Rucinski M, Parenti AR, Nardelli GB, Drews K, Nussdorfer GG and Malendowicz LK: Leptin and leptin receptor expression in the myometrium and uterine myomas: is leptin involved in tumor development?. Int J Oncol 27: 1505-1509, 2005.
APA
Markowska, A., Belloni, A.S., Rucinski, M., Parenti, A.R., Nardelli, G.B., Drews, K. ... Malendowicz, L.K. (2005). Leptin and leptin receptor expression in the myometrium and uterine myomas: is leptin involved in tumor development?. International Journal of Oncology, 27, 1505-1509. https://doi.org/10.3892/ijo.27.6.1505
MLA
Markowska, A., Belloni, A. S., Rucinski, M., Parenti, A. R., Nardelli, G. B., Drews, K., Nussdorfer, G. G., Malendowicz, L. K."Leptin and leptin receptor expression in the myometrium and uterine myomas: is leptin involved in tumor development?". International Journal of Oncology 27.6 (2005): 1505-1509.
Chicago
Markowska, A., Belloni, A. S., Rucinski, M., Parenti, A. R., Nardelli, G. B., Drews, K., Nussdorfer, G. G., Malendowicz, L. K."Leptin and leptin receptor expression in the myometrium and uterine myomas: is leptin involved in tumor development?". International Journal of Oncology 27, no. 6 (2005): 1505-1509. https://doi.org/10.3892/ijo.27.6.1505
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