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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2005 Volume 27 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2005 Volume 27 Issue 6

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Article

Expression of the licensing factors, Cdt1 and Geminin, in human colon cancer

  • Authors:
    • V. Bravou
    • H. Nishitani
    • S. Y. Song
    • S. Taraviras
    • J. Varakis

  • View Affiliations / Copyright

    Affiliations: Department of Anatomy and Histology-Embryology, School of Medicine, University of Patras, 26500 Rio, Patras, Greece
  • Pages: 1511-1518
    |
    Published online on: December 1, 2005
       https://doi.org/10.3892/ijo.27.6.1511
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Abstract

Licensing of chromatin for replication is an evolu-tionarily conserved step in the control of cell division and genomic integrity. Proteins that participate in licensing have been recently documented to denote the proliferative state of cells and they have been proposed as diagnostic and prognostic markers in human cancer. Cdt1 was recently discovered as an important licensing factor, that is inhibited by Geminin. In the present study we analyzed Cdt1 and Geminin expression in human colon cancer. We showed that Cdt1 protein is highly expressed in human neoplastic lesions of the colon while its cell-cycle phase-specific expression profile appears preserved during human carcinogenesis. Similarly, Geminin, Cdt1's inhibitor, is also overexpressed in colon carcinomas and its expression correlates with significant clinicopathological parameters of the disease. Moreover, both Cdt1 and Geminin expression are severely downregulated upon differentiation of Caco-2 cells, an in vitro model of intestinal epithelial differentiation.

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Copy and paste a formatted citation
Spandidos Publications style
Bravou V, Nishitani H, Song SY, Taraviras S and Varakis J: Expression of the licensing factors, Cdt1 and Geminin, in human colon cancer. Int J Oncol 27: 1511-1518, 2005.
APA
Bravou, V., Nishitani, H., Song, S.Y., Taraviras, S., & Varakis, J. (2005). Expression of the licensing factors, Cdt1 and Geminin, in human colon cancer. International Journal of Oncology, 27, 1511-1518. https://doi.org/10.3892/ijo.27.6.1511
MLA
Bravou, V., Nishitani, H., Song, S. Y., Taraviras, S., Varakis, J."Expression of the licensing factors, Cdt1 and Geminin, in human colon cancer". International Journal of Oncology 27.6 (2005): 1511-1518.
Chicago
Bravou, V., Nishitani, H., Song, S. Y., Taraviras, S., Varakis, J."Expression of the licensing factors, Cdt1 and Geminin, in human colon cancer". International Journal of Oncology 27, no. 6 (2005): 1511-1518. https://doi.org/10.3892/ijo.27.6.1511
Copy and paste a formatted citation
x
Spandidos Publications style
Bravou V, Nishitani H, Song SY, Taraviras S and Varakis J: Expression of the licensing factors, Cdt1 and Geminin, in human colon cancer. Int J Oncol 27: 1511-1518, 2005.
APA
Bravou, V., Nishitani, H., Song, S.Y., Taraviras, S., & Varakis, J. (2005). Expression of the licensing factors, Cdt1 and Geminin, in human colon cancer. International Journal of Oncology, 27, 1511-1518. https://doi.org/10.3892/ijo.27.6.1511
MLA
Bravou, V., Nishitani, H., Song, S. Y., Taraviras, S., Varakis, J."Expression of the licensing factors, Cdt1 and Geminin, in human colon cancer". International Journal of Oncology 27.6 (2005): 1511-1518.
Chicago
Bravou, V., Nishitani, H., Song, S. Y., Taraviras, S., Varakis, J."Expression of the licensing factors, Cdt1 and Geminin, in human colon cancer". International Journal of Oncology 27, no. 6 (2005): 1511-1518. https://doi.org/10.3892/ijo.27.6.1511
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