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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2005 Volume 27 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2005 Volume 27 Issue 6

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Article

Doxazosin induces apoptosis in LNCaP prostate cancer cell line through DNA binding and DNA-dependent protein kinase down-regulation

  • Authors:
    • José M.. Arencibia
    • Mónica Del Rio
    • Ana Bonnin
    • Rita Lopes
    • Nicholas R. Lemoine
    • Mónica López-Barahona

  • View Affiliations / Copyright

    Affiliations: Departamento de Bioquímica, Facultad de CC. Biosanitarias, Universidad Francisco de Vitoria, Ctra. 28223 Madrid, Spain
  • Pages: 1617-1623
    |
    Published online on: December 1, 2005
       https://doi.org/10.3892/ijo.27.6.1617
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Abstract

Doxazosin is a quinazoline-based compound acting as an α-1-adrenergic inhibitor shown to induce apoptosis in prostate cancer cell lines via an α-1-adrenergic receptor-independent mechanism. To better understand the mechanism of doxazosin-induced apoptosis in prostate cancer, we performed cDNA microarray to analyze gene expression changes produced by doxazosin in the androgen-dependent human prostate cancer cell line, LNCaP. We found that 70 and 92 genes were deregulated after 8 and 24 h of doxazosin treatment, respectively. These genes are involved in several cellular processes such as cell-cycle regulation, cell adhesion and signal transduction pathways. Strikingly, we found that doxazosin induces deregulation of genes implicated in DNA replication and repair, such as GADD45A, XRCC5 and PRKDC. These facts, together with the demonstration of the ability of doxazosin to bind DNA, allowed us to propose a novel mechanism of action for doxazosin in prostate cancer cells that implies DNA-damage mediated apoptosis by down-regulation of XRCC5 and PRKDC genes.

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Copy and paste a formatted citation
Spandidos Publications style
Arencibia JM, Del Rio M, Bonnin A, Lopes R, Lemoine NR and López-Barahona M: Doxazosin induces apoptosis in LNCaP prostate cancer cell line through DNA binding and DNA-dependent protein kinase down-regulation. Int J Oncol 27: 1617-1623, 2005.
APA
Arencibia, J.M., Del Rio, M., Bonnin, A., Lopes, R., Lemoine, N.R., & López-Barahona, M. (2005). Doxazosin induces apoptosis in LNCaP prostate cancer cell line through DNA binding and DNA-dependent protein kinase down-regulation. International Journal of Oncology, 27, 1617-1623. https://doi.org/10.3892/ijo.27.6.1617
MLA
Arencibia, J. M., Del Rio, M., Bonnin, A., Lopes, R., Lemoine, N. R., López-Barahona, M."Doxazosin induces apoptosis in LNCaP prostate cancer cell line through DNA binding and DNA-dependent protein kinase down-regulation". International Journal of Oncology 27.6 (2005): 1617-1623.
Chicago
Arencibia, J. M., Del Rio, M., Bonnin, A., Lopes, R., Lemoine, N. R., López-Barahona, M."Doxazosin induces apoptosis in LNCaP prostate cancer cell line through DNA binding and DNA-dependent protein kinase down-regulation". International Journal of Oncology 27, no. 6 (2005): 1617-1623. https://doi.org/10.3892/ijo.27.6.1617
Copy and paste a formatted citation
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Spandidos Publications style
Arencibia JM, Del Rio M, Bonnin A, Lopes R, Lemoine NR and López-Barahona M: Doxazosin induces apoptosis in LNCaP prostate cancer cell line through DNA binding and DNA-dependent protein kinase down-regulation. Int J Oncol 27: 1617-1623, 2005.
APA
Arencibia, J.M., Del Rio, M., Bonnin, A., Lopes, R., Lemoine, N.R., & López-Barahona, M. (2005). Doxazosin induces apoptosis in LNCaP prostate cancer cell line through DNA binding and DNA-dependent protein kinase down-regulation. International Journal of Oncology, 27, 1617-1623. https://doi.org/10.3892/ijo.27.6.1617
MLA
Arencibia, J. M., Del Rio, M., Bonnin, A., Lopes, R., Lemoine, N. R., López-Barahona, M."Doxazosin induces apoptosis in LNCaP prostate cancer cell line through DNA binding and DNA-dependent protein kinase down-regulation". International Journal of Oncology 27.6 (2005): 1617-1623.
Chicago
Arencibia, J. M., Del Rio, M., Bonnin, A., Lopes, R., Lemoine, N. R., López-Barahona, M."Doxazosin induces apoptosis in LNCaP prostate cancer cell line through DNA binding and DNA-dependent protein kinase down-regulation". International Journal of Oncology 27, no. 6 (2005): 1617-1623. https://doi.org/10.3892/ijo.27.6.1617
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