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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2006 Volume 28 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2006 Volume 28 Issue 3

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Article

Gene expression profiles of oral leukoplakia and carcinoma: Genome-wide comparison analysis using oligonucleotide microarray technology

  • Authors:
    • Takeshi Odani
    • Daisuke Ito
    • Ming-Heng Li
    • Ai Kawamata
    • Tomohide Isobe
    • Masayasu Iwase
    • Masao Nagumo

  • View Affiliations / Copyright

    Affiliations: Department of Oral & Maxillofacial Surgery, School of Dentistry, Showa University, Ohta-ku, Tokyo 145-8515, Japan. odani@senzoku.showa-u.ac.jp
  • Pages: 619-624
    |
    Published online on: March 1, 2006
       https://doi.org/10.3892/ijo.28.3.619
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Abstract

Although leukoplakia is the most common precancerous lesion of the oral cavity, its molecular biological properties are largely unknown. The aim of this study was to identify the genes responsible for its pathogenesis and malignant transformation using oligonucleotide microarray technology. The expression profiles of 8,800 genes in human oral leukoplakia (n=4) and oral squamous cell carcinoma (OSCC) (n=2) were analyzed using the Affymetrix GeneChip® system and the results were confirmed with RT-PCR. Eight genes were up-regulated (>2.0-fold) and ten were down-regulated (<0.5-fold) in all leukoplakias analyzed with the GeneChip. In particular, loricrin and keratins displayed greater differences between normal tissue and leukoplakia. Some of the 18 alternatively expressed genes were markedly down-regulated in squamous cell carcinoma compared with leukoplakia. Our data suggested that gene abnormalities in cytoskeleton network components might be responsible for the development and progression of oral leukoplakia.

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Copy and paste a formatted citation
Spandidos Publications style
Odani T, Ito D, Li M, Kawamata A, Isobe T, Iwase M and Nagumo M: Gene expression profiles of oral leukoplakia and carcinoma: Genome-wide comparison analysis using oligonucleotide microarray technology. Int J Oncol 28: 619-624, 2006.
APA
Odani, T., Ito, D., Li, M., Kawamata, A., Isobe, T., Iwase, M., & Nagumo, M. (2006). Gene expression profiles of oral leukoplakia and carcinoma: Genome-wide comparison analysis using oligonucleotide microarray technology. International Journal of Oncology, 28, 619-624. https://doi.org/10.3892/ijo.28.3.619
MLA
Odani, T., Ito, D., Li, M., Kawamata, A., Isobe, T., Iwase, M., Nagumo, M."Gene expression profiles of oral leukoplakia and carcinoma: Genome-wide comparison analysis using oligonucleotide microarray technology". International Journal of Oncology 28.3 (2006): 619-624.
Chicago
Odani, T., Ito, D., Li, M., Kawamata, A., Isobe, T., Iwase, M., Nagumo, M."Gene expression profiles of oral leukoplakia and carcinoma: Genome-wide comparison analysis using oligonucleotide microarray technology". International Journal of Oncology 28, no. 3 (2006): 619-624. https://doi.org/10.3892/ijo.28.3.619
Copy and paste a formatted citation
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Spandidos Publications style
Odani T, Ito D, Li M, Kawamata A, Isobe T, Iwase M and Nagumo M: Gene expression profiles of oral leukoplakia and carcinoma: Genome-wide comparison analysis using oligonucleotide microarray technology. Int J Oncol 28: 619-624, 2006.
APA
Odani, T., Ito, D., Li, M., Kawamata, A., Isobe, T., Iwase, M., & Nagumo, M. (2006). Gene expression profiles of oral leukoplakia and carcinoma: Genome-wide comparison analysis using oligonucleotide microarray technology. International Journal of Oncology, 28, 619-624. https://doi.org/10.3892/ijo.28.3.619
MLA
Odani, T., Ito, D., Li, M., Kawamata, A., Isobe, T., Iwase, M., Nagumo, M."Gene expression profiles of oral leukoplakia and carcinoma: Genome-wide comparison analysis using oligonucleotide microarray technology". International Journal of Oncology 28.3 (2006): 619-624.
Chicago
Odani, T., Ito, D., Li, M., Kawamata, A., Isobe, T., Iwase, M., Nagumo, M."Gene expression profiles of oral leukoplakia and carcinoma: Genome-wide comparison analysis using oligonucleotide microarray technology". International Journal of Oncology 28, no. 3 (2006): 619-624. https://doi.org/10.3892/ijo.28.3.619
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