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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2006 Volume 28 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2006 Volume 28 Issue 3

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Article

Growth inhibitory effect of triple anti-tumor gene transfer using Semliki Forest virus vector in glioblastoma cells

  • Authors:
    • Jong-Soo Lee
    • Jun-Han Lee
    • Haryoung Poo
    • Mi-Suk Kim
    • Seung-Hoon Lee
    • Moon-Hee Sung
    • Chul-Joong Kim

  • View Affiliations / Copyright

    Affiliations: BioLeaders corporation, Daejeon, Korea
  • Pages: 649-654
    |
    Published online on: March 1, 2006
       https://doi.org/10.3892/ijo.28.3.649
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Abstract

The gene delivery of multiple tumor suppressors can provide an efficient tumor therapy in the case of malignant human glioblastomas containing multiple genetic alteration and inactivation. As such, the current study presents a new delivery system that can simultaneously express three anti-tumor genes using a Semliki Forest virus (SFV) vector in the expectation of combined or synergistic effects of angiogenesis inhibition by angiostatin and apoptosis induction by p53, PTEN and the rSFV particle itself. Recombinant SFV (rSFV) containing three anti-tumor genes (rSFV-Agt/p53/PTEN) were found to efficiently transduce and express each anti-tumor gene in glioblastoma cells. In addition, rSFV-Agt/p53/PTEN also resulted in a more effective induction of apoptosis in vitro and inhibition of tumor growth in nude mice when compared with other rSFVs containing only one or two anti-tumor genes. Accordingly, the current results demonstrate that a triple anti-tumor gene transfer using an rSFV vector would be a powerful strategy for regional cancer gene therapy.

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Copy and paste a formatted citation
Spandidos Publications style
Lee J, Lee J, Poo H, Kim M, Lee S, Sung M and Kim C: Growth inhibitory effect of triple anti-tumor gene transfer using Semliki Forest virus vector in glioblastoma cells. Int J Oncol 28: 649-654, 2006.
APA
Lee, J., Lee, J., Poo, H., Kim, M., Lee, S., Sung, M., & Kim, C. (2006). Growth inhibitory effect of triple anti-tumor gene transfer using Semliki Forest virus vector in glioblastoma cells. International Journal of Oncology, 28, 649-654. https://doi.org/10.3892/ijo.28.3.649
MLA
Lee, J., Lee, J., Poo, H., Kim, M., Lee, S., Sung, M., Kim, C."Growth inhibitory effect of triple anti-tumor gene transfer using Semliki Forest virus vector in glioblastoma cells". International Journal of Oncology 28.3 (2006): 649-654.
Chicago
Lee, J., Lee, J., Poo, H., Kim, M., Lee, S., Sung, M., Kim, C."Growth inhibitory effect of triple anti-tumor gene transfer using Semliki Forest virus vector in glioblastoma cells". International Journal of Oncology 28, no. 3 (2006): 649-654. https://doi.org/10.3892/ijo.28.3.649
Copy and paste a formatted citation
x
Spandidos Publications style
Lee J, Lee J, Poo H, Kim M, Lee S, Sung M and Kim C: Growth inhibitory effect of triple anti-tumor gene transfer using Semliki Forest virus vector in glioblastoma cells. Int J Oncol 28: 649-654, 2006.
APA
Lee, J., Lee, J., Poo, H., Kim, M., Lee, S., Sung, M., & Kim, C. (2006). Growth inhibitory effect of triple anti-tumor gene transfer using Semliki Forest virus vector in glioblastoma cells. International Journal of Oncology, 28, 649-654. https://doi.org/10.3892/ijo.28.3.649
MLA
Lee, J., Lee, J., Poo, H., Kim, M., Lee, S., Sung, M., Kim, C."Growth inhibitory effect of triple anti-tumor gene transfer using Semliki Forest virus vector in glioblastoma cells". International Journal of Oncology 28.3 (2006): 649-654.
Chicago
Lee, J., Lee, J., Poo, H., Kim, M., Lee, S., Sung, M., Kim, C."Growth inhibitory effect of triple anti-tumor gene transfer using Semliki Forest virus vector in glioblastoma cells". International Journal of Oncology 28, no. 3 (2006): 649-654. https://doi.org/10.3892/ijo.28.3.649
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