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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2006 Volume 28 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2006 Volume 28 Issue 3

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Article

Protein kinase CK2 subunits are positive regulators of AKT kinase

  • Authors:
    • Barbara Guerra

  • View Affiliations / Copyright

    Affiliations: Institute for Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense, Denmark. bag@bmb.sdu.dk
  • Pages: 685-693
    |
    Published online on: March 1, 2006
       https://doi.org/10.3892/ijo.28.3.685
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Abstract

Protein kinase CK2 is a highly conserved serine/threonine kinase ubiquitously distributed in all investigated eukaryotes and involved in several intracellular pathways which control, among others, cell cycle, proliferation, apoptosis and transformation. Similarly, the PI3K-AKT pathway deregulation has been shown to play an important role in tumor development and tumor response to anti-cancer treatment. In this study, it is shown that the specific inhibition of the PI3K-AKT signaling pathway in combination with depletion of CK2 subunits by antisense oligodeoxynucleotides leads to an enhanced drug-induced apoptotic response. Moreover, in vitro as well as in vivo studies show that the individual CK2 subunits interact with AKT kinase and that the complex formation is not modulated by the phosphorylation status of AKT. Furthermore, the fact that the interaction between CK2 subunits and AKT enhances AKT kinase activity identifies a novel molecular mechanism that leads to modulation of AKT activation raising the possibility that CK2 and AKT might be implicated in common pathways that control cell proliferation and survival.

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Copy and paste a formatted citation
Spandidos Publications style
Guerra B: Protein kinase CK2 subunits are positive regulators of AKT kinase. Int J Oncol 28: 685-693, 2006.
APA
Guerra, B. (2006). Protein kinase CK2 subunits are positive regulators of AKT kinase. International Journal of Oncology, 28, 685-693. https://doi.org/10.3892/ijo.28.3.685
MLA
Guerra, B."Protein kinase CK2 subunits are positive regulators of AKT kinase". International Journal of Oncology 28.3 (2006): 685-693.
Chicago
Guerra, B."Protein kinase CK2 subunits are positive regulators of AKT kinase". International Journal of Oncology 28, no. 3 (2006): 685-693. https://doi.org/10.3892/ijo.28.3.685
Copy and paste a formatted citation
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Spandidos Publications style
Guerra B: Protein kinase CK2 subunits are positive regulators of AKT kinase. Int J Oncol 28: 685-693, 2006.
APA
Guerra, B. (2006). Protein kinase CK2 subunits are positive regulators of AKT kinase. International Journal of Oncology, 28, 685-693. https://doi.org/10.3892/ijo.28.3.685
MLA
Guerra, B."Protein kinase CK2 subunits are positive regulators of AKT kinase". International Journal of Oncology 28.3 (2006): 685-693.
Chicago
Guerra, B."Protein kinase CK2 subunits are positive regulators of AKT kinase". International Journal of Oncology 28, no. 3 (2006): 685-693. https://doi.org/10.3892/ijo.28.3.685
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