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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2006 Volume 28 Issue 3

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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An International Open Access Journal Devoted to General Medicine.

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March 2006 Volume 28 Issue 3

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Article

Native anti-tumor responses elicited by immunization with a low dose of unmodified live tumor cells

  • Authors:
    • Sheng Wu
    • Shi-Quan Wang
    • Jing Zhang
    • Xiang-Yang Tan
    • Jian-Ning Liu

  • View Affiliations / Copyright

    Affiliations: Institute of Molecular Medicine and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, P.R. China
  • Pages: 731-736
    |
    Published online on: March 1, 2006
       https://doi.org/10.3892/ijo.28.3.731
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Abstract

The present study demonstrates that immunization with a low dose of unmodified live myeloma tumor cells (FO) elicited tumor-specific immunity. BALB/c mice were vaccinated with 104 live dendritic cells (DC)-FO fusion cells or 103 live FO cells. 80% of vaccinated mice survived from the later challenge with 1x106 FO cells, whereas all control mice developed tumors. Additionally, vaccination with live FO cells gave no protection against the growth of Lewis lung carcinoma cells in C57BL/6 mice. Cellular immunity was found to be primarily responsible for anti-tumor responses. In an adoptive immune model, the development of myeloma was greatly reduced by transfusion of lymphocytes but not sera from mice immunized with FO. T cells from immunized mice also induced lysis of FO cells in the cytotoxic T lymphocyte (CTL) assay. After co-culture with FO, IFN-γ released from immunized T helper cells increased >10-fold, while IL-4 remained unchanged in comparison with control T cells. These findings provided the first evidence that immunization with a low dose of unmodified live FO cells was safe to mice and capable of eliciting specific protective immunity against tumor growth.

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Copy and paste a formatted citation
Spandidos Publications style
Wu S, Wang S, Zhang J, Tan X and Liu J: Native anti-tumor responses elicited by immunization with a low dose of unmodified live tumor cells. Int J Oncol 28: 731-736, 2006.
APA
Wu, S., Wang, S., Zhang, J., Tan, X., & Liu, J. (2006). Native anti-tumor responses elicited by immunization with a low dose of unmodified live tumor cells. International Journal of Oncology, 28, 731-736. https://doi.org/10.3892/ijo.28.3.731
MLA
Wu, S., Wang, S., Zhang, J., Tan, X., Liu, J."Native anti-tumor responses elicited by immunization with a low dose of unmodified live tumor cells". International Journal of Oncology 28.3 (2006): 731-736.
Chicago
Wu, S., Wang, S., Zhang, J., Tan, X., Liu, J."Native anti-tumor responses elicited by immunization with a low dose of unmodified live tumor cells". International Journal of Oncology 28, no. 3 (2006): 731-736. https://doi.org/10.3892/ijo.28.3.731
Copy and paste a formatted citation
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Spandidos Publications style
Wu S, Wang S, Zhang J, Tan X and Liu J: Native anti-tumor responses elicited by immunization with a low dose of unmodified live tumor cells. Int J Oncol 28: 731-736, 2006.
APA
Wu, S., Wang, S., Zhang, J., Tan, X., & Liu, J. (2006). Native anti-tumor responses elicited by immunization with a low dose of unmodified live tumor cells. International Journal of Oncology, 28, 731-736. https://doi.org/10.3892/ijo.28.3.731
MLA
Wu, S., Wang, S., Zhang, J., Tan, X., Liu, J."Native anti-tumor responses elicited by immunization with a low dose of unmodified live tumor cells". International Journal of Oncology 28.3 (2006): 731-736.
Chicago
Wu, S., Wang, S., Zhang, J., Tan, X., Liu, J."Native anti-tumor responses elicited by immunization with a low dose of unmodified live tumor cells". International Journal of Oncology 28, no. 3 (2006): 731-736. https://doi.org/10.3892/ijo.28.3.731
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