Prolyl isomerase Pin1 expression predicts prognosis in patients with esophageal squamous cell carcinoma and correlates with cyclinD1 expression

  • Authors:
    • Minoru Fukuchi
    • Yasuyuki Fukai
    • Hitoshi Kimura
    • Makoto Sohda
    • Tatsuya Miyazaki
    • Masanobu Nakajima
    • Norihiro Masuda
    • Katsuhiko Tsukada
    • Hiroyuki Kato
    • Hiroyuki Kuwano
  • View Affiliations

  • Published online on: August 1, 2006     https://doi.org/10.3892/ijo.29.2.329
  • Pages: 329-334
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Abstract

Esophageal carcinoma is one of the most lethal tumors, and identification of prognostic factors for patients with this disease is important. Propyl isomerase Pin1 is overexpressed in some human cancers and thought to be an important regulator of cyclinD1. However, the relationships between Pin1 expression and clinicopathologic features in patients with esophageal squamous cell carcinoma (SCC) have not been explored. Here, we investigated the role of Pin1 in association with cyclinD1 in esophageal SCC progression and its clinicopathological significance. The expressions of Pin1 and cyclinD1 were examined immunohistochemically in surgical specimens from 119 esophageal SCC patients. The expression levels of Pin1 and cyclinD1 in 6 esophageal SCC-derived cell lines were compared with those in an immortalized human esophageal cell line by western blotting. Pin1 overexpression was correlated with lymph node metastasis (P=0.0384), and its expression was related to cyclinD1 expression. Pin1 expression was correlated with poor prognosis in esophageal SCC patients (P=0.0044), and found to be an independent prognostic factor (P=0.0277). Pin1 was overexpressed in 5 of 6 esophageal SCC-derived cell lines compared with immortalized esophageal keratinocytes. Moreover, the Pin1 level was correlated with the cyclinD1 level in 4 of the 6 cell lines. In conclusion, Pin1 expression is correlated with cyclinD1 expression and may be a useful prognostic factor for esophageal SCC.

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August 2006
Volume 29 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Fukuchi M, Fukai Y, Kimura H, Sohda M, Miyazaki T, Nakajima M, Masuda N, Tsukada K, Kato H, Kuwano H, Kuwano H, et al: Prolyl isomerase Pin1 expression predicts prognosis in patients with esophageal squamous cell carcinoma and correlates with cyclinD1 expression. Int J Oncol 29: 329-334, 2006
APA
Fukuchi, M., Fukai, Y., Kimura, H., Sohda, M., Miyazaki, T., Nakajima, M. ... Kuwano, H. (2006). Prolyl isomerase Pin1 expression predicts prognosis in patients with esophageal squamous cell carcinoma and correlates with cyclinD1 expression. International Journal of Oncology, 29, 329-334. https://doi.org/10.3892/ijo.29.2.329
MLA
Fukuchi, M., Fukai, Y., Kimura, H., Sohda, M., Miyazaki, T., Nakajima, M., Masuda, N., Tsukada, K., Kato, H., Kuwano, H."Prolyl isomerase Pin1 expression predicts prognosis in patients with esophageal squamous cell carcinoma and correlates with cyclinD1 expression". International Journal of Oncology 29.2 (2006): 329-334.
Chicago
Fukuchi, M., Fukai, Y., Kimura, H., Sohda, M., Miyazaki, T., Nakajima, M., Masuda, N., Tsukada, K., Kato, H., Kuwano, H."Prolyl isomerase Pin1 expression predicts prognosis in patients with esophageal squamous cell carcinoma and correlates with cyclinD1 expression". International Journal of Oncology 29, no. 2 (2006): 329-334. https://doi.org/10.3892/ijo.29.2.329