A gene encoding a family with sequence similarity 84, member A (FAM84A) enhanced migration of human colon cancer cells

  • Authors:
    • Takaaki Kobayashi
    • Tadahiko Masaki
    • Masanori Sugiyama
    • Yutaka Atomi
    • Yoichi Furukawa
    • Yusuke Nakamura
  • View Affiliations

  • Published online on: August 1, 2006     https://doi.org/10.3892/ijo.29.2.341
  • Pages: 341-347
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Abstract

Using genome-wide cDNA microarray analysis, we identified a number of genes whose expression was up-regulated frequently in colorectal cancer. One of these was a gene termed FAM84A that was not expressed in any of the 23 normal tissues examined except the testis. Although immuno-cytochemical staining revealed localization of FAM84A protein in the subcellular membrane region, the staining was limited to the region lacking attachment with neighboring cells. In addition, we found that exogenous FAM84A expression increased cell motility in NIH3T3 cells, and that phosphorylation of serine 38 of FAM84A was associated with morphology of cells. Our results indicate a possibility that up-regulation of FAM84A plays a critical role in progression of colon cancer.

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August 2006
Volume 29 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Kobayashi T, Masaki T, Sugiyama M, Atomi Y, Furukawa Y and Nakamura Y: A gene encoding a family with sequence similarity 84, member A (FAM84A) enhanced migration of human colon cancer cells. Int J Oncol 29: 341-347, 2006
APA
Kobayashi, T., Masaki, T., Sugiyama, M., Atomi, Y., Furukawa, Y., & Nakamura, Y. (2006). A gene encoding a family with sequence similarity 84, member A (FAM84A) enhanced migration of human colon cancer cells. International Journal of Oncology, 29, 341-347. https://doi.org/10.3892/ijo.29.2.341
MLA
Kobayashi, T., Masaki, T., Sugiyama, M., Atomi, Y., Furukawa, Y., Nakamura, Y."A gene encoding a family with sequence similarity 84, member A (FAM84A) enhanced migration of human colon cancer cells". International Journal of Oncology 29.2 (2006): 341-347.
Chicago
Kobayashi, T., Masaki, T., Sugiyama, M., Atomi, Y., Furukawa, Y., Nakamura, Y."A gene encoding a family with sequence similarity 84, member A (FAM84A) enhanced migration of human colon cancer cells". International Journal of Oncology 29, no. 2 (2006): 341-347. https://doi.org/10.3892/ijo.29.2.341