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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2006 Volume 29 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2006 Volume 29 Issue 3

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Article

Acetylsalicylic acid enhances antiproliferative effects of the EGFR inhibitor gefitinib in the absence of activating mutations in gastric cancer

  • Authors:
    • J. C. Becker
    • C. Müller-Tidow
    • M. Stolte
    • T. Fujimori
    • N. Tidow
    • A. M. Ilea
    • C. Brandts
    • L. Tickenbrock
    • H. Serve
    • W. E. Berdel
    • W. Domschke
    • T. Pohle
  • View Affiliations / Copyright

    Affiliations: Department of Medicine B, University of Münster, D-48129 Münster, Germany
  • Pages: 615-623
    |
    Published online on: September 1, 2006
       https://doi.org/10.3892/ijo.29.3.615
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Abstract

The epidermal growth factor receptor (EGFR) is highly expressed in gastric cancer indicating its suitability as a target for receptor tyrosine kinase (RTK) inhibitors. In the current study we explored the role of EGFR and its potential use as a therapeutic target in gastric cancer. First we analyzed 66 gastric cancer samples of Asian and Caucasian patients for the presence of EGFR mutations. No activating EGFR mutations were found and gefitinib alone was only weakly effective in gastric cancer cell lines. However, acetylsalicylic acid (ASA) significantly enhanced the inhibitory effects of gefitinib indicating synergistic action. Whole genome expression profiling indicated significant regulation of 120 genes in the case of co-administration of gefitinib and ASA (32 induced, 88 repressed) in gastric adenocarcinoma cells. Further analyses indicated that several important signalling pathways were effectively inhibited by simultaneous exposure to gefitinib and ASA. Our findings indicate that although gastric cancer does not seem to harbour mutations which render the cancer cells constitutively susceptible to gefitinib, the co-administration of ASA can strengthen RTK inhibitor activity in adenocarcinoma cells by EGFR activation. This is the first report of effective modulation of EGFR-inhibition activity in cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Becker JC, Müller-Tidow C, Stolte M, Fujimori T, Tidow N, Ilea AM, Brandts C, Tickenbrock L, Serve H, Berdel WE, Berdel WE, et al: Acetylsalicylic acid enhances antiproliferative effects of the EGFR inhibitor gefitinib in the absence of activating mutations in gastric cancer. Int J Oncol 29: 615-623, 2006.
APA
Becker, J.C., Müller-Tidow, C., Stolte, M., Fujimori, T., Tidow, N., Ilea, A.M. ... Pohle, T. (2006). Acetylsalicylic acid enhances antiproliferative effects of the EGFR inhibitor gefitinib in the absence of activating mutations in gastric cancer. International Journal of Oncology, 29, 615-623. https://doi.org/10.3892/ijo.29.3.615
MLA
Becker, J. C., Müller-Tidow, C., Stolte, M., Fujimori, T., Tidow, N., Ilea, A. M., Brandts, C., Tickenbrock, L., Serve, H., Berdel, W. E., Domschke, W., Pohle, T."Acetylsalicylic acid enhances antiproliferative effects of the EGFR inhibitor gefitinib in the absence of activating mutations in gastric cancer". International Journal of Oncology 29.3 (2006): 615-623.
Chicago
Becker, J. C., Müller-Tidow, C., Stolte, M., Fujimori, T., Tidow, N., Ilea, A. M., Brandts, C., Tickenbrock, L., Serve, H., Berdel, W. E., Domschke, W., Pohle, T."Acetylsalicylic acid enhances antiproliferative effects of the EGFR inhibitor gefitinib in the absence of activating mutations in gastric cancer". International Journal of Oncology 29, no. 3 (2006): 615-623. https://doi.org/10.3892/ijo.29.3.615
Copy and paste a formatted citation
x
Spandidos Publications style
Becker JC, Müller-Tidow C, Stolte M, Fujimori T, Tidow N, Ilea AM, Brandts C, Tickenbrock L, Serve H, Berdel WE, Berdel WE, et al: Acetylsalicylic acid enhances antiproliferative effects of the EGFR inhibitor gefitinib in the absence of activating mutations in gastric cancer. Int J Oncol 29: 615-623, 2006.
APA
Becker, J.C., Müller-Tidow, C., Stolte, M., Fujimori, T., Tidow, N., Ilea, A.M. ... Pohle, T. (2006). Acetylsalicylic acid enhances antiproliferative effects of the EGFR inhibitor gefitinib in the absence of activating mutations in gastric cancer. International Journal of Oncology, 29, 615-623. https://doi.org/10.3892/ijo.29.3.615
MLA
Becker, J. C., Müller-Tidow, C., Stolte, M., Fujimori, T., Tidow, N., Ilea, A. M., Brandts, C., Tickenbrock, L., Serve, H., Berdel, W. E., Domschke, W., Pohle, T."Acetylsalicylic acid enhances antiproliferative effects of the EGFR inhibitor gefitinib in the absence of activating mutations in gastric cancer". International Journal of Oncology 29.3 (2006): 615-623.
Chicago
Becker, J. C., Müller-Tidow, C., Stolte, M., Fujimori, T., Tidow, N., Ilea, A. M., Brandts, C., Tickenbrock, L., Serve, H., Berdel, W. E., Domschke, W., Pohle, T."Acetylsalicylic acid enhances antiproliferative effects of the EGFR inhibitor gefitinib in the absence of activating mutations in gastric cancer". International Journal of Oncology 29, no. 3 (2006): 615-623. https://doi.org/10.3892/ijo.29.3.615
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