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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2006 Volume 29 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2006 Volume 29 Issue 4

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Article

Additive effects of Cox-1 and Cox-2 inhibition on breast cancer in vitro

  • Authors:
    • David W. McFadden
    • Dale R. Riggs
    • Barbara J. Jackson
    • Cynthia Cunningham

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV 26506, USA. dmcfadden@hsc.wvu.edu
  • Pages: 1019-1023
    |
    Published online on: October 1, 2006
       https://doi.org/10.3892/ijo.29.4.1019
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Abstract

We hypothesized that combined treatment with Cox-1 and Cox-2 specific inhibitiors would exhibit synergistic effects against breast cancer in vitro. Two human breast cancer cell lines (HTB26, MCF-7) were treated with catechin (Cox-1 inhibitor) or NS398 (Cox-2 inhibitor) at 100 µM as both single and combined treatments. Reductions in cell growth were observed in both cell lines at 24 and 72 h in both single and combined treatments (p<0.001). Combined treatment produced a significantly greater inhibition as compared to single agents alone. Upon cell cycle evaluation, Cox-1 and -2 antagonism increased G1 and G2 phase fractions in MCF-7 cells (p<0.001 and p<0.05 respectively). No additive changes were observed when the two agents were combined. An increase in the G2 phase was observed in the HTB26 cells when treated with NS398 alone (p<0.001). However, a decrease in the S-phase was observed when these cells were treated with NS398, as a single agent (p<0.01) or when the two agents were combined (p<0.01). The significant and additive effects exhibited by the combination of Cox-1 and -2 inhibitors and their effects on cell cycle suggest that these agents could become an effective treatment modality for carcinoma of the breast.

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Copy and paste a formatted citation
Spandidos Publications style
McFadden DW, Riggs DR, Jackson BJ and Cunningham C: Additive effects of Cox-1 and Cox-2 inhibition on breast cancer in vitro. Int J Oncol 29: 1019-1023, 2006.
APA
McFadden, D.W., Riggs, D.R., Jackson, B.J., & Cunningham, C. (2006). Additive effects of Cox-1 and Cox-2 inhibition on breast cancer in vitro. International Journal of Oncology, 29, 1019-1023. https://doi.org/10.3892/ijo.29.4.1019
MLA
McFadden, D. W., Riggs, D. R., Jackson, B. J., Cunningham, C."Additive effects of Cox-1 and Cox-2 inhibition on breast cancer in vitro". International Journal of Oncology 29.4 (2006): 1019-1023.
Chicago
McFadden, D. W., Riggs, D. R., Jackson, B. J., Cunningham, C."Additive effects of Cox-1 and Cox-2 inhibition on breast cancer in vitro". International Journal of Oncology 29, no. 4 (2006): 1019-1023. https://doi.org/10.3892/ijo.29.4.1019
Copy and paste a formatted citation
x
Spandidos Publications style
McFadden DW, Riggs DR, Jackson BJ and Cunningham C: Additive effects of Cox-1 and Cox-2 inhibition on breast cancer in vitro. Int J Oncol 29: 1019-1023, 2006.
APA
McFadden, D.W., Riggs, D.R., Jackson, B.J., & Cunningham, C. (2006). Additive effects of Cox-1 and Cox-2 inhibition on breast cancer in vitro. International Journal of Oncology, 29, 1019-1023. https://doi.org/10.3892/ijo.29.4.1019
MLA
McFadden, D. W., Riggs, D. R., Jackson, B. J., Cunningham, C."Additive effects of Cox-1 and Cox-2 inhibition on breast cancer in vitro". International Journal of Oncology 29.4 (2006): 1019-1023.
Chicago
McFadden, D. W., Riggs, D. R., Jackson, B. J., Cunningham, C."Additive effects of Cox-1 and Cox-2 inhibition on breast cancer in vitro". International Journal of Oncology 29, no. 4 (2006): 1019-1023. https://doi.org/10.3892/ijo.29.4.1019
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