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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2006 Volume 29 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2006 Volume 29 Issue 4

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Article

Chromosomal end fusion resulting from telomere erosion increases susceptibility to radiation via multinucleation: Effect of p53

  • Authors:
    • Yeun-Jin Ju
    • Jeong Eun Park
    • Kyoung Mi Juhn
    • Jaemin Jeong
    • Miyong Yun
    • Myung-Jin Park
    • Gil-Hong Park
    • Kang-Yell Choi
    • Myung-Haeng Cho
    • Kwok-Kin Wong
    • Won-Bong Park
    • Kee-Ho Lee

  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Oncology, Korea Institute of Radiological and Medical Sciences, Seoul 139-706, Korea
  • Pages: 753-763
    |
    Published online on: October 1, 2006
       https://doi.org/10.3892/ijo.29.4.753
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Abstract

Loss of p53 tumor suppressor facilitates acquisition of telomerase activity. In fact, both p53 inactivation and telomerase activation are frequently found in human cancers. p53 inactivation, however, eliminates or attenuates the biological responses to telomerase inhibition and the eventual telomere erosion. We show that telomere erosion can increase the susceptibility to radiation, irrespective of p53 status. Both telomerase inhibition and critically shortened telomere with significant change of chromosomal end-to-end fusion were essential for the enhancement of radiosensitivity. The enhancement was correlated with greater formation of multinucleated cells. p53 inactivation did not eliminate the observed generation of chromosomal fusion and multinucleation, and the resulting increased susceptibility to radiation, as opposed to the previously proved role of p53 in mediating cellular responses to telomere dysfunction. The present findings suggest the importance of chromosomal end fusion in modulating radiosensitivity rather than p53 DNA damage signaling. Thus, the suggested anticancer radiotherapeutic strategy combined with telomerase inhibition could clinically be applicable to cancers, irrespective of p53 status.

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Copy and paste a formatted citation
Spandidos Publications style
Ju Y, Park JE, Juhn KM, Jeong J, Yun M, Park M, Park G, Choi K, Cho M, Wong K, Wong K, et al: Chromosomal end fusion resulting from telomere erosion increases susceptibility to radiation via multinucleation: Effect of p53. Int J Oncol 29: 753-763, 2006.
APA
Ju, Y., Park, J.E., Juhn, K.M., Jeong, J., Yun, M., Park, M. ... Lee, K. (2006). Chromosomal end fusion resulting from telomere erosion increases susceptibility to radiation via multinucleation: Effect of p53. International Journal of Oncology, 29, 753-763. https://doi.org/10.3892/ijo.29.4.753
MLA
Ju, Y., Park, J. E., Juhn, K. M., Jeong, J., Yun, M., Park, M., Park, G., Choi, K., Cho, M., Wong, K., Park, W., Lee, K."Chromosomal end fusion resulting from telomere erosion increases susceptibility to radiation via multinucleation: Effect of p53". International Journal of Oncology 29.4 (2006): 753-763.
Chicago
Ju, Y., Park, J. E., Juhn, K. M., Jeong, J., Yun, M., Park, M., Park, G., Choi, K., Cho, M., Wong, K., Park, W., Lee, K."Chromosomal end fusion resulting from telomere erosion increases susceptibility to radiation via multinucleation: Effect of p53". International Journal of Oncology 29, no. 4 (2006): 753-763. https://doi.org/10.3892/ijo.29.4.753
Copy and paste a formatted citation
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Spandidos Publications style
Ju Y, Park JE, Juhn KM, Jeong J, Yun M, Park M, Park G, Choi K, Cho M, Wong K, Wong K, et al: Chromosomal end fusion resulting from telomere erosion increases susceptibility to radiation via multinucleation: Effect of p53. Int J Oncol 29: 753-763, 2006.
APA
Ju, Y., Park, J.E., Juhn, K.M., Jeong, J., Yun, M., Park, M. ... Lee, K. (2006). Chromosomal end fusion resulting from telomere erosion increases susceptibility to radiation via multinucleation: Effect of p53. International Journal of Oncology, 29, 753-763. https://doi.org/10.3892/ijo.29.4.753
MLA
Ju, Y., Park, J. E., Juhn, K. M., Jeong, J., Yun, M., Park, M., Park, G., Choi, K., Cho, M., Wong, K., Park, W., Lee, K."Chromosomal end fusion resulting from telomere erosion increases susceptibility to radiation via multinucleation: Effect of p53". International Journal of Oncology 29.4 (2006): 753-763.
Chicago
Ju, Y., Park, J. E., Juhn, K. M., Jeong, J., Yun, M., Park, M., Park, G., Choi, K., Cho, M., Wong, K., Park, W., Lee, K."Chromosomal end fusion resulting from telomere erosion increases susceptibility to radiation via multinucleation: Effect of p53". International Journal of Oncology 29, no. 4 (2006): 753-763. https://doi.org/10.3892/ijo.29.4.753
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