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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2006 Volume 29 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2006 Volume 29 Issue 5

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Article

Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKβ overexpression in human breast cancers

  • Authors:
    • Bo Ping
    • Xianghuo He
    • Weiya Xia
    • Dung-Fang Lee
    • Yongkun Wei
    • Dihua Yu
    • Gordon Mills
    • Daren Shi
    • Mien-Chie Hung

  • View Affiliations / Copyright

    Affiliations: Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
  • Pages: 1103-1110
    |
    Published online on: November 1, 2006
       https://doi.org/10.3892/ijo.29.5.1103
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Abstract

Regulation of cytoplasmic p21CIP/WAF1 (p21) is of great clinical significance in molecular oncology due to its identification as an antiapoptotic factor, a poor survival predictor as well as a drug-resistance inducer. A retrospective study of the immunohistochemical (IHC) profiles of 128 human primary breast cancers showed that increased total and cytoplasmic p21 expression were highly associated with the expression of IκB kinase β (IKKβ), the major catalytic subunit of the IKK complex and another crucial player in tumorigenesis and drug resistance. The causal relationship study based on cultured cell lines, MDA-MB-453 and MCF-7, confirmed that IKKβ overexpression did upregulate protein levels of total and cytoplasmic p21. Mechanistic investigation demonstrated that IKKβ increased p21 expression through upregulation of p21 mRNA level. Moreover, by Western blotting, IKKβ was found to be able to upregulate Akt phosphorylation on Ser 473. This novel finding indicated that IKKβ could mediate cytoplasmic p21 accumulation via activation of its downstream target Akt, which was known to phosphorylate p21 and lead to cytoplasmic localization of p21.

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Copy and paste a formatted citation
Spandidos Publications style
Ping B, He X, Xia W, Lee D, Wei Y, Yu D, Mills G, Shi D and Hung M: Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKβ overexpression in human breast cancers. Int J Oncol 29: 1103-1110, 2006.
APA
Ping, B., He, X., Xia, W., Lee, D., Wei, Y., Yu, D. ... Hung, M. (2006). Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKβ overexpression in human breast cancers. International Journal of Oncology, 29, 1103-1110. https://doi.org/10.3892/ijo.29.5.1103
MLA
Ping, B., He, X., Xia, W., Lee, D., Wei, Y., Yu, D., Mills, G., Shi, D., Hung, M."Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKβ overexpression in human breast cancers". International Journal of Oncology 29.5 (2006): 1103-1110.
Chicago
Ping, B., He, X., Xia, W., Lee, D., Wei, Y., Yu, D., Mills, G., Shi, D., Hung, M."Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKβ overexpression in human breast cancers". International Journal of Oncology 29, no. 5 (2006): 1103-1110. https://doi.org/10.3892/ijo.29.5.1103
Copy and paste a formatted citation
x
Spandidos Publications style
Ping B, He X, Xia W, Lee D, Wei Y, Yu D, Mills G, Shi D and Hung M: Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKβ overexpression in human breast cancers. Int J Oncol 29: 1103-1110, 2006.
APA
Ping, B., He, X., Xia, W., Lee, D., Wei, Y., Yu, D. ... Hung, M. (2006). Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKβ overexpression in human breast cancers. International Journal of Oncology, 29, 1103-1110. https://doi.org/10.3892/ijo.29.5.1103
MLA
Ping, B., He, X., Xia, W., Lee, D., Wei, Y., Yu, D., Mills, G., Shi, D., Hung, M."Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKβ overexpression in human breast cancers". International Journal of Oncology 29.5 (2006): 1103-1110.
Chicago
Ping, B., He, X., Xia, W., Lee, D., Wei, Y., Yu, D., Mills, G., Shi, D., Hung, M."Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKβ overexpression in human breast cancers". International Journal of Oncology 29, no. 5 (2006): 1103-1110. https://doi.org/10.3892/ijo.29.5.1103
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