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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2006 Volume 29 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2006 Volume 29 Issue 5

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Article

Corticosteroids induce chemotherapy resistance in the majority of tumour cells from bone, brain, breast, cervix, melanoma and neuroblastoma

  • Authors:
    • Chengwen Zhang
    • Benjamin Beckermann
    • Georgios Kallifatidis
    • Zheng Liu
    • Werner Rittgen
    • Lutz Edler
    • Peter Büchler
    • Klaus-Michael Debatin
    • Markus W. Büchler
    • Helmut Friess
    • Ingrid Herr

  • View Affiliations / Copyright

    Affiliations: Research Group Molecular OncoSurgery, University of Heidelberg, Heidelberg, Germany
  • Pages: 1295-1301
    |
    Published online on: November 1, 2006
       https://doi.org/10.3892/ijo.29.5.1295
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Abstract

Glucocorticoids (GCs) such as dexamethasone (DEX) have been widely used as co-medication in cancer therapy because they have potent proapoptotic properties in lymphoid cells, can reduce nausea, and alleviate acute toxic effects in healthy tissue. However, GCs are used in a supportive-care role, even though no prospective clinical studies have assessed the effect of these steroids on the growth of solid tumours. Data from preclinical and, to some extent, clinical studies, suggest that GCs induce treatment resistance in some solid tumours. Since it is unknown whether GC-induced resistance occurs only occasionally or is a more common phenomenon, we performed a screening study using several established cell lines from bone, brain, breast and cervix carcinoma as well as melanoma and neuroblastoma together with fresh surgical resections from patients with breast cancer. We found that DEX inhibits cisplatin and 5-fluorouracil-induced apoptosis and promotes the growth of the majority of examined malignant cells. In contrast, and as expected, DEX acted pro-apoptotically and promoted the cytotoxic effect of chemotherapy in established and primary lymphoid cells. Thus, these data demonstrate the need for detailed molecular studies to clarify the mechanism of differential glucocorticoid signaling as well as controlled, prospective clinical studies.

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Copy and paste a formatted citation
Spandidos Publications style
Zhang C, Beckermann B, Kallifatidis G, Liu Z, Rittgen W, Edler L, Büchler P, Debatin K, Büchler MW, Friess H, Friess H, et al: Corticosteroids induce chemotherapy resistance in the majority of tumour cells from bone, brain, breast, cervix, melanoma and neuroblastoma. Int J Oncol 29: 1295-1301, 2006.
APA
Zhang, C., Beckermann, B., Kallifatidis, G., Liu, Z., Rittgen, W., Edler, L. ... Herr, I. (2006). Corticosteroids induce chemotherapy resistance in the majority of tumour cells from bone, brain, breast, cervix, melanoma and neuroblastoma. International Journal of Oncology, 29, 1295-1301. https://doi.org/10.3892/ijo.29.5.1295
MLA
Zhang, C., Beckermann, B., Kallifatidis, G., Liu, Z., Rittgen, W., Edler, L., Büchler, P., Debatin, K., Büchler, M. W., Friess, H., Herr, I."Corticosteroids induce chemotherapy resistance in the majority of tumour cells from bone, brain, breast, cervix, melanoma and neuroblastoma". International Journal of Oncology 29.5 (2006): 1295-1301.
Chicago
Zhang, C., Beckermann, B., Kallifatidis, G., Liu, Z., Rittgen, W., Edler, L., Büchler, P., Debatin, K., Büchler, M. W., Friess, H., Herr, I."Corticosteroids induce chemotherapy resistance in the majority of tumour cells from bone, brain, breast, cervix, melanoma and neuroblastoma". International Journal of Oncology 29, no. 5 (2006): 1295-1301. https://doi.org/10.3892/ijo.29.5.1295
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang C, Beckermann B, Kallifatidis G, Liu Z, Rittgen W, Edler L, Büchler P, Debatin K, Büchler MW, Friess H, Friess H, et al: Corticosteroids induce chemotherapy resistance in the majority of tumour cells from bone, brain, breast, cervix, melanoma and neuroblastoma. Int J Oncol 29: 1295-1301, 2006.
APA
Zhang, C., Beckermann, B., Kallifatidis, G., Liu, Z., Rittgen, W., Edler, L. ... Herr, I. (2006). Corticosteroids induce chemotherapy resistance in the majority of tumour cells from bone, brain, breast, cervix, melanoma and neuroblastoma. International Journal of Oncology, 29, 1295-1301. https://doi.org/10.3892/ijo.29.5.1295
MLA
Zhang, C., Beckermann, B., Kallifatidis, G., Liu, Z., Rittgen, W., Edler, L., Büchler, P., Debatin, K., Büchler, M. W., Friess, H., Herr, I."Corticosteroids induce chemotherapy resistance in the majority of tumour cells from bone, brain, breast, cervix, melanoma and neuroblastoma". International Journal of Oncology 29.5 (2006): 1295-1301.
Chicago
Zhang, C., Beckermann, B., Kallifatidis, G., Liu, Z., Rittgen, W., Edler, L., Büchler, P., Debatin, K., Büchler, M. W., Friess, H., Herr, I."Corticosteroids induce chemotherapy resistance in the majority of tumour cells from bone, brain, breast, cervix, melanoma and neuroblastoma". International Journal of Oncology 29, no. 5 (2006): 1295-1301. https://doi.org/10.3892/ijo.29.5.1295
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