RECOVERY OF RESPONSE TO ADRIAMYCIN AND CYCLOPHOSPHAMIDE BY LONIDAMINE IN PREVIOUSLY TREATED METASTATIC BREAST-CANCER PATIENTS
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- Published online on: August 1, 1993 https://doi.org/10.3892/ijo.3.2.213
- Pages: 213-217
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Abstract
Thirty-one patients with metastatic breast cancer not responding or progressing after initial response to adriamycin + cyclophosphamide (AC) treatment entered a phase 11 study with oral lonidamine in association to AC. Objective clinical responses were observed in 10 patients (32%) and consisted of 1 complete + 9 partial remissions. Disease stability and progression were observed in 8 and 13 cases, respectively. These results were obtained with a marginal toxicity in addition to that already reported for AC therapy, the main additional side effect being myalgia, which was easily manageable in most cases.