FEC (FLUOROURACIL, EPIRUBICIN, CYCLOPHOSPHAMIDE) PLUS GRANULOCYTE MACROPHAGE-COLONY-STIMULATING FACTOR (GM-CSF) IN ADVANCED OR INFLAMMATORY BREAST-CANCER - A DOSE-FINDING STUDY

  • Authors:
    • V LORUSSO
    • C TATULLI
    • F BERARDI
    • M BRANDI
    • A DEMITRIO
    • A CATALDI
    • A FIORETTO
    • R SARCINA
    • F SCHITTULLI
    • M DELENA
  • View Affiliations

  • Published online on: August 1, 1993     https://doi.org/10.3892/ijo.3.2.223
  • Pages: 223-228
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Abstract

Seven patients with inflammatory and 11 with metastatic breast cancer were treated with high dose FEC chemotherapy plus GM-CSF; 5-fluorouracil and cyclophosphamide were administered at 500 mg/m2/iv/day 1, epirubicin at three dose levels: 100 mg, 120 mg and 140 mg/m2/iv/day 1 every three weeks (six patients per level). GM-CSF was administered at a dosage of 5 mg/kg/sc from day 5 to 12 of each cycle. The overall response rate was 83% (95% CI: 66%-100%) with 22% complete response. The median response duration for patients with metastatic disease was 7 months (range: 4-10). The hematological toxicity was moderate but reversible due to GM-CSF rescue; mucositis represented the dose limiting toxicity. In conclusion, the increase of dose intensity resulted in a higher response rate but not longer response duration, which must be taken into account when administering high-dose chemotherapy with growth factor rescue.

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August 1993
Volume 3 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
LORUSSO V, TATULLI C, BERARDI F, BRANDI M, DEMITRIO A, CATALDI A, FIORETTO A, SARCINA R, SCHITTULLI F, DELENA M, DELENA M, et al: FEC (FLUOROURACIL, EPIRUBICIN, CYCLOPHOSPHAMIDE) PLUS GRANULOCYTE MACROPHAGE-COLONY-STIMULATING FACTOR (GM-CSF) IN ADVANCED OR INFLAMMATORY BREAST-CANCER - A DOSE-FINDING STUDY. Int J Oncol 3: 223-228, 1993.
APA
LORUSSO, V., TATULLI, C., BERARDI, F., BRANDI, M., DEMITRIO, A., CATALDI, A. ... DELENA, M. (1993). FEC (FLUOROURACIL, EPIRUBICIN, CYCLOPHOSPHAMIDE) PLUS GRANULOCYTE MACROPHAGE-COLONY-STIMULATING FACTOR (GM-CSF) IN ADVANCED OR INFLAMMATORY BREAST-CANCER - A DOSE-FINDING STUDY. International Journal of Oncology, 3, 223-228. https://doi.org/10.3892/ijo.3.2.223
MLA
LORUSSO, V., TATULLI, C., BERARDI, F., BRANDI, M., DEMITRIO, A., CATALDI, A., FIORETTO, A., SARCINA, R., SCHITTULLI, F., DELENA, M."FEC (FLUOROURACIL, EPIRUBICIN, CYCLOPHOSPHAMIDE) PLUS GRANULOCYTE MACROPHAGE-COLONY-STIMULATING FACTOR (GM-CSF) IN ADVANCED OR INFLAMMATORY BREAST-CANCER - A DOSE-FINDING STUDY". International Journal of Oncology 3.2 (1993): 223-228.
Chicago
LORUSSO, V., TATULLI, C., BERARDI, F., BRANDI, M., DEMITRIO, A., CATALDI, A., FIORETTO, A., SARCINA, R., SCHITTULLI, F., DELENA, M."FEC (FLUOROURACIL, EPIRUBICIN, CYCLOPHOSPHAMIDE) PLUS GRANULOCYTE MACROPHAGE-COLONY-STIMULATING FACTOR (GM-CSF) IN ADVANCED OR INFLAMMATORY BREAST-CANCER - A DOSE-FINDING STUDY". International Journal of Oncology 3, no. 2 (1993): 223-228. https://doi.org/10.3892/ijo.3.2.223