PEDIATRIC OSTEOSARCOMA - TREATMENT OF THE PRIMARY TUMOR WITH INTRAVENOUS CIS-DIAMMINEDICHLOROPLATINUM-II (CDP) - COMPARISON OF THE RESULTS WITH THE REPORTED EFFICACY OF INTRAARTERIAL CDP

  • Authors:
    • N JAFFE
    • DM JAFFE
    • AK RAYMOND
    • P PEARSON
    • R ROBERTSON
    • EE KIM
  • View Affiliations

  • Published online on: August 1, 1993     https://doi.org/10.3892/ijo.3.2.273
  • Pages: 273-278
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Abstract

Intravenous cis-Diamminedichloroplatinum-II (CDP) was administered to 10 patients with osteosarcoma to treat the primary tumor in 8 and bone metastases in 2. Three patients also had pulmonary metastases. The intent was to deliver 7 courses (150 mg/M2 q 2 weeks) over 3 months (total cumulative dose 1050/mg/M2). However, this was only accomplished in 2 patients; in the remaining 8 the full course was not administered because of temporary renal insufficiency (3), tumor escape (1) and apparent response after 4-6 courses suggesting that no further benefit would accrue (4). Overall, clinical and/or radiologic responses were observed in 9 patients. In 6 of 9 tumors subjected to surgical resection (66%), necrosis in excess of 65% was observed. Optimum results were achieved with a cumulative dose of 600 mg/M2 administered over 6 weeks. These results suggest that intravenous CDP may be as efficacious as intra-arterial CDP which has produced similar responses.

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August 1993
Volume 3 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
JAFFE N, JAFFE D, RAYMOND A, PEARSON P, ROBERTSON R and KIM E: PEDIATRIC OSTEOSARCOMA - TREATMENT OF THE PRIMARY TUMOR WITH INTRAVENOUS CIS-DIAMMINEDICHLOROPLATINUM-II (CDP) - COMPARISON OF THE RESULTS WITH THE REPORTED EFFICACY OF INTRAARTERIAL CDP. Int J Oncol 3: 273-278, 1993
APA
JAFFE, N., JAFFE, D., RAYMOND, A., PEARSON, P., ROBERTSON, R., & KIM, E. (1993). PEDIATRIC OSTEOSARCOMA - TREATMENT OF THE PRIMARY TUMOR WITH INTRAVENOUS CIS-DIAMMINEDICHLOROPLATINUM-II (CDP) - COMPARISON OF THE RESULTS WITH THE REPORTED EFFICACY OF INTRAARTERIAL CDP. International Journal of Oncology, 3, 273-278. https://doi.org/10.3892/ijo.3.2.273
MLA
JAFFE, N., JAFFE, D., RAYMOND, A., PEARSON, P., ROBERTSON, R., KIM, E."PEDIATRIC OSTEOSARCOMA - TREATMENT OF THE PRIMARY TUMOR WITH INTRAVENOUS CIS-DIAMMINEDICHLOROPLATINUM-II (CDP) - COMPARISON OF THE RESULTS WITH THE REPORTED EFFICACY OF INTRAARTERIAL CDP". International Journal of Oncology 3.2 (1993): 273-278.
Chicago
JAFFE, N., JAFFE, D., RAYMOND, A., PEARSON, P., ROBERTSON, R., KIM, E."PEDIATRIC OSTEOSARCOMA - TREATMENT OF THE PRIMARY TUMOR WITH INTRAVENOUS CIS-DIAMMINEDICHLOROPLATINUM-II (CDP) - COMPARISON OF THE RESULTS WITH THE REPORTED EFFICACY OF INTRAARTERIAL CDP". International Journal of Oncology 3, no. 2 (1993): 273-278. https://doi.org/10.3892/ijo.3.2.273