RETINOIC ACID INDUCES LOSS OF VIRAL-DNA, PHENOTYPIC REVERSION AND TRANSFORMATION-RESISTANCE OF BOVINE PAPILLOMAVIRUS TYPE-1 DNA-TRANSFORMED CELLS

  • Authors:
    • G LI
    • SS TSANG
    • P LAM
    • HF STICH
  • View Affiliations

  • Published online on: August 1, 1993     https://doi.org/10.3892/ijo.3.2.319
  • Pages: 319-324
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Abstract

Two revertant cell lines were obtained by treatment of bovine papillomavirus type 1 (BPV-1) DNA-transformed cell lines B3 and BF3 with 5 muM of all-trans-retinoic acid (RA) for 10 weeks. The revertant cells were devoid of detectable viral DNA, no longer exhibited a transformed morphology and lost the ability to form multilayered transformed foci. They replicated with a population doubling time of 16-18 hours, which was also characteristic of the C127, B3 and BF3 cells. They attained a similar saturation density as the C127 cells. However, the revertant cells were at least 5- to 7-fold more resistant than the parental C127 cells to neoplastic transformation induced by BPV-1 DNA.

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August 1993
Volume 3 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
LI G, TSANG S, LAM P and STICH H: RETINOIC ACID INDUCES LOSS OF VIRAL-DNA, PHENOTYPIC REVERSION AND TRANSFORMATION-RESISTANCE OF BOVINE PAPILLOMAVIRUS TYPE-1 DNA-TRANSFORMED CELLS. Int J Oncol 3: 319-324, 1993
APA
LI, G., TSANG, S., LAM, P., & STICH, H. (1993). RETINOIC ACID INDUCES LOSS OF VIRAL-DNA, PHENOTYPIC REVERSION AND TRANSFORMATION-RESISTANCE OF BOVINE PAPILLOMAVIRUS TYPE-1 DNA-TRANSFORMED CELLS. International Journal of Oncology, 3, 319-324. https://doi.org/10.3892/ijo.3.2.319
MLA
LI, G., TSANG, S., LAM, P., STICH, H."RETINOIC ACID INDUCES LOSS OF VIRAL-DNA, PHENOTYPIC REVERSION AND TRANSFORMATION-RESISTANCE OF BOVINE PAPILLOMAVIRUS TYPE-1 DNA-TRANSFORMED CELLS". International Journal of Oncology 3.2 (1993): 319-324.
Chicago
LI, G., TSANG, S., LAM, P., STICH, H."RETINOIC ACID INDUCES LOSS OF VIRAL-DNA, PHENOTYPIC REVERSION AND TRANSFORMATION-RESISTANCE OF BOVINE PAPILLOMAVIRUS TYPE-1 DNA-TRANSFORMED CELLS". International Journal of Oncology 3, no. 2 (1993): 319-324. https://doi.org/10.3892/ijo.3.2.319