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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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August 1993 Volume 3 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 1993 Volume 3 Issue 2

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Article

ASSESSMENT OF CELL-PROLIFERATION KINETICS IN FAMILIAL ADENOMATOUS POLYPOSIS BY PCNA IMMUNOSTAINING

  • Authors:
    • R YOSHIKAWA
    • T HATADA
    • M KUSUNOKI
    • T YAMAMURA
    • J UTSUNOMIYA

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    Affiliations: Affliations not specified
  • Pages: 341-345
    |
    Published online on: August 1, 1993
       https://doi.org/10.3892/ijo.3.2.341
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Abstract

Cell proliferation was assessed using immunostaining for proliferative cell nuclear antigen in 10 patients with familial adenomatous polyposis (10 normal-appearing mucosa, 19 adenoma and 3 adenocarcinoma specimens) and 6 control subjects (rectosigmoid mucosal biopsies). The total labeling index (percentage ratio of the number of labeled cells to the total number of cells in a column) was 31.70+/-9.32% (mean+/-SD) in adenocarcinoma, 27.95+/-4.24% in adenoma (p<0.001 versus normal-appearing mucosa), 19.54+/-3.46% in normal-appearing mucosa (p<0.01 versus control mucosa) and 13.73+/-5.19% in control mucosa. Adenomas showed hyperproliferation and upward expansion of the proliferative zone. When adenomas were classified by size, their diameter was related to the proliferative activity (r=0.73, p<0.01). The normal-appearing mucosa already showed changes in cell proliferation. In an animal study, a linear correlation between the labeling index for proliferative nuclear cell antigen and that for bromodeoxyuridine was demonstrated in rat colonic mucosa (r=0.96, p<0.001). These results suggest that immunostaining for proliferative cell nuclear antigen can be used as a convenient and precise method of studying cell proliferation kinetics and that the increase of the proliferative activity of adenomas in proportion to their size provides some support for the adenoma-carcinoma sequence.

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Copy and paste a formatted citation
Spandidos Publications style
YOSHIKAWA R, HATADA T, KUSUNOKI M, YAMAMURA T and UTSUNOMIYA J: ASSESSMENT OF CELL-PROLIFERATION KINETICS IN FAMILIAL ADENOMATOUS POLYPOSIS BY PCNA IMMUNOSTAINING. Int J Oncol 3: 341-345, 1993.
APA
YOSHIKAWA, R., HATADA, T., KUSUNOKI, M., YAMAMURA, T., & UTSUNOMIYA, J. (1993). ASSESSMENT OF CELL-PROLIFERATION KINETICS IN FAMILIAL ADENOMATOUS POLYPOSIS BY PCNA IMMUNOSTAINING. International Journal of Oncology, 3, 341-345. https://doi.org/10.3892/ijo.3.2.341
MLA
YOSHIKAWA, R., HATADA, T., KUSUNOKI, M., YAMAMURA, T., UTSUNOMIYA, J."ASSESSMENT OF CELL-PROLIFERATION KINETICS IN FAMILIAL ADENOMATOUS POLYPOSIS BY PCNA IMMUNOSTAINING". International Journal of Oncology 3.2 (1993): 341-345.
Chicago
YOSHIKAWA, R., HATADA, T., KUSUNOKI, M., YAMAMURA, T., UTSUNOMIYA, J."ASSESSMENT OF CELL-PROLIFERATION KINETICS IN FAMILIAL ADENOMATOUS POLYPOSIS BY PCNA IMMUNOSTAINING". International Journal of Oncology 3, no. 2 (1993): 341-345. https://doi.org/10.3892/ijo.3.2.341
Copy and paste a formatted citation
x
Spandidos Publications style
YOSHIKAWA R, HATADA T, KUSUNOKI M, YAMAMURA T and UTSUNOMIYA J: ASSESSMENT OF CELL-PROLIFERATION KINETICS IN FAMILIAL ADENOMATOUS POLYPOSIS BY PCNA IMMUNOSTAINING. Int J Oncol 3: 341-345, 1993.
APA
YOSHIKAWA, R., HATADA, T., KUSUNOKI, M., YAMAMURA, T., & UTSUNOMIYA, J. (1993). ASSESSMENT OF CELL-PROLIFERATION KINETICS IN FAMILIAL ADENOMATOUS POLYPOSIS BY PCNA IMMUNOSTAINING. International Journal of Oncology, 3, 341-345. https://doi.org/10.3892/ijo.3.2.341
MLA
YOSHIKAWA, R., HATADA, T., KUSUNOKI, M., YAMAMURA, T., UTSUNOMIYA, J."ASSESSMENT OF CELL-PROLIFERATION KINETICS IN FAMILIAL ADENOMATOUS POLYPOSIS BY PCNA IMMUNOSTAINING". International Journal of Oncology 3.2 (1993): 341-345.
Chicago
YOSHIKAWA, R., HATADA, T., KUSUNOKI, M., YAMAMURA, T., UTSUNOMIYA, J."ASSESSMENT OF CELL-PROLIFERATION KINETICS IN FAMILIAL ADENOMATOUS POLYPOSIS BY PCNA IMMUNOSTAINING". International Journal of Oncology 3, no. 2 (1993): 341-345. https://doi.org/10.3892/ijo.3.2.341
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