LIMITED SMALL-CELL LUNG-CARCINOMA - HIGH COMPLETE RESPONSE RATE AND SURVIVAL WITH SHORT INTENSIVE CHEMOTHERAPY AND EXTENSIVE IRRADIATION - RESULTS OF A PILOT-STUDY

  • Authors:
    • JM TOURANI
    • R LEVY
    • Y COSCAS
    • P EVEN
    • JM ANDRIEU
  • View Affiliations

  • Published online on: August 1, 1993     https://doi.org/10.3892/ijo.3.2.347
  • Pages: 347-353
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Abstract

Sixteen patients with limited small-cell lung carcinoma (SCLC) were treated with three monthly courses of intensive chemotherapy (cisplatin: 40 mg/m2/day (D), D1, D2 and D3; cyclophosphamide: 750 mg/m2/D, D4 and D5; adriamycin: 50 mg/m2/D, D5; vindesine: 2 mg/m2/D, D1 and D5; etoposide: 100 mg/m2/D, D1, D2 and D3; methylprednisolone: 120 mg/m2/D, D1 to D5). Thoracic and prophylactic brain plus spinal area irradiations were performed after completion of the third chemotherapy cycle. The complete response rate was 100%. Of these 16 patients, 7 experienced a relapse from 5 to 31 months after completion of treatment. The three-year survival rate was 54%. The main toxicities were hematological (neutropenia and thrombocytopenia) and digestive. We conclude from this pilot study that intensive five-drug chemotherapy is a highly effective regimen for limited SCLC. This intensive chemotherapy regimen and extensive irradiation is feasible without major toxicity. This type of intensive combined-modality program deserves further study to definitely establish its long-term efficacy in localized SCLC.

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August 1993
Volume 3 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
TOURANI J, LEVY R, COSCAS Y, EVEN P and ANDRIEU J: LIMITED SMALL-CELL LUNG-CARCINOMA - HIGH COMPLETE RESPONSE RATE AND SURVIVAL WITH SHORT INTENSIVE CHEMOTHERAPY AND EXTENSIVE IRRADIATION - RESULTS OF A PILOT-STUDY. Int J Oncol 3: 347-353, 1993
APA
TOURANI, J., LEVY, R., COSCAS, Y., EVEN, P., & ANDRIEU, J. (1993). LIMITED SMALL-CELL LUNG-CARCINOMA - HIGH COMPLETE RESPONSE RATE AND SURVIVAL WITH SHORT INTENSIVE CHEMOTHERAPY AND EXTENSIVE IRRADIATION - RESULTS OF A PILOT-STUDY. International Journal of Oncology, 3, 347-353. https://doi.org/10.3892/ijo.3.2.347
MLA
TOURANI, J., LEVY, R., COSCAS, Y., EVEN, P., ANDRIEU, J."LIMITED SMALL-CELL LUNG-CARCINOMA - HIGH COMPLETE RESPONSE RATE AND SURVIVAL WITH SHORT INTENSIVE CHEMOTHERAPY AND EXTENSIVE IRRADIATION - RESULTS OF A PILOT-STUDY". International Journal of Oncology 3.2 (1993): 347-353.
Chicago
TOURANI, J., LEVY, R., COSCAS, Y., EVEN, P., ANDRIEU, J."LIMITED SMALL-CELL LUNG-CARCINOMA - HIGH COMPLETE RESPONSE RATE AND SURVIVAL WITH SHORT INTENSIVE CHEMOTHERAPY AND EXTENSIVE IRRADIATION - RESULTS OF A PILOT-STUDY". International Journal of Oncology 3, no. 2 (1993): 347-353. https://doi.org/10.3892/ijo.3.2.347