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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 1993 Volume 3 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 1993 Volume 3 Issue 3

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Article

P53 EXPRESSION IN END-STAGE SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK PRIOR TO CHEMOTHERAPY TREATMENT - EXPRESSION CORRELATES WITH A VERY POOR CLINICAL OUTCOME

  • Authors:
    • JK FIELD
    • A MALLIRI
    • SA BUTT
    • JR GOSNEY
    • D PHILLIPS
    • DA SPANDIDOS
    • AS JONES
  • View Affiliations / Copyright

    Affiliations: UNIV LIVERPOOL,DEPT PATHOL,LIVERPOOL L69 3BX,ENGLAND. NATL HELLEN RES FDN,GR-11635 ATHENS,GREECE. UNIV CRETE,SCH MED,IRAKLION,GREECE. UNIV LIVERPOOL,DEPT OTORHINOLARYNGOL,LIVERPOOL L69 3BX,ENGLAND.
  • Pages: 431-435
    |
    Published online on: September 1, 1993
       https://doi.org/10.3892/ijo.3.3.431
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Abstract

p53 expression was assessed immunohistochemically in 24 'end stage disease' patients with squamous cell carcinoma of the head and neck, prior to selection for a chemotherapy trial. Twelve patients were assigned to each arm of the trial; cisplatinum arm or the cisplatinum and nifedipine arm. p53 expression was assessed using the CM-1 antibody in specimens from biopsies or surgically removed tissue at the time these patients were assessed as end stage disease. Sixty-six per cent had p53 positive nuclear staining but no correlation was found between p53 staining and age, sex, site of primary tumour, tumour stage, or site of the recurrence. Three patients responded to cisplatinum chemotherapy treatment, two of whom had p53 positive staining. p53 survival curves were calculated for these patients from the date they were assessed as 'end stage disease', p53 overexpression was found to correlate with a very poor clinical outcome (P<0.05). Survival curves for 109 head and neck patients calculated from the date the disease first presented showed no correlation with p53 expression.

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Copy and paste a formatted citation
Spandidos Publications style
FIELD J, MALLIRI A, BUTT S, GOSNEY J, PHILLIPS D, SPANDIDOS D and JONES A: P53 EXPRESSION IN END-STAGE SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK PRIOR TO CHEMOTHERAPY TREATMENT - EXPRESSION CORRELATES WITH A VERY POOR CLINICAL OUTCOME. Int J Oncol 3: 431-435, 1993.
APA
FIELD, J., MALLIRI, A., BUTT, S., GOSNEY, J., PHILLIPS, D., SPANDIDOS, D., & JONES, A. (1993). P53 EXPRESSION IN END-STAGE SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK PRIOR TO CHEMOTHERAPY TREATMENT - EXPRESSION CORRELATES WITH A VERY POOR CLINICAL OUTCOME. International Journal of Oncology, 3, 431-435. https://doi.org/10.3892/ijo.3.3.431
MLA
FIELD, J., MALLIRI, A., BUTT, S., GOSNEY, J., PHILLIPS, D., SPANDIDOS, D., JONES, A."P53 EXPRESSION IN END-STAGE SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK PRIOR TO CHEMOTHERAPY TREATMENT - EXPRESSION CORRELATES WITH A VERY POOR CLINICAL OUTCOME". International Journal of Oncology 3.3 (1993): 431-435.
Chicago
FIELD, J., MALLIRI, A., BUTT, S., GOSNEY, J., PHILLIPS, D., SPANDIDOS, D., JONES, A."P53 EXPRESSION IN END-STAGE SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK PRIOR TO CHEMOTHERAPY TREATMENT - EXPRESSION CORRELATES WITH A VERY POOR CLINICAL OUTCOME". International Journal of Oncology 3, no. 3 (1993): 431-435. https://doi.org/10.3892/ijo.3.3.431
Copy and paste a formatted citation
x
Spandidos Publications style
FIELD J, MALLIRI A, BUTT S, GOSNEY J, PHILLIPS D, SPANDIDOS D and JONES A: P53 EXPRESSION IN END-STAGE SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK PRIOR TO CHEMOTHERAPY TREATMENT - EXPRESSION CORRELATES WITH A VERY POOR CLINICAL OUTCOME. Int J Oncol 3: 431-435, 1993.
APA
FIELD, J., MALLIRI, A., BUTT, S., GOSNEY, J., PHILLIPS, D., SPANDIDOS, D., & JONES, A. (1993). P53 EXPRESSION IN END-STAGE SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK PRIOR TO CHEMOTHERAPY TREATMENT - EXPRESSION CORRELATES WITH A VERY POOR CLINICAL OUTCOME. International Journal of Oncology, 3, 431-435. https://doi.org/10.3892/ijo.3.3.431
MLA
FIELD, J., MALLIRI, A., BUTT, S., GOSNEY, J., PHILLIPS, D., SPANDIDOS, D., JONES, A."P53 EXPRESSION IN END-STAGE SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK PRIOR TO CHEMOTHERAPY TREATMENT - EXPRESSION CORRELATES WITH A VERY POOR CLINICAL OUTCOME". International Journal of Oncology 3.3 (1993): 431-435.
Chicago
FIELD, J., MALLIRI, A., BUTT, S., GOSNEY, J., PHILLIPS, D., SPANDIDOS, D., JONES, A."P53 EXPRESSION IN END-STAGE SQUAMOUS-CELL CARCINOMA OF THE HEAD AND NECK PRIOR TO CHEMOTHERAPY TREATMENT - EXPRESSION CORRELATES WITH A VERY POOR CLINICAL OUTCOME". International Journal of Oncology 3, no. 3 (1993): 431-435. https://doi.org/10.3892/ijo.3.3.431
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