MYTH OF TUMOR IMMUNOLOGY (REVIEW)

CHIGIRA,M; ARITA,S; WATANABE,H

doi:10.3892/ijo.3.4.645

October 1993 Volume 3 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

October 1993 Volume 3 Issue 4

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Cover Legend PDF

Review

MYTH OF TUMOR IMMUNOLOGY (REVIEW)

Authors:
- M CHIGIRA
- S ARITA
- H WATANABE
View Affiliations / Copyright

Affiliations: Affliations not specified
Pages: 645-653
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Published online on: October 1, 1993

https://doi.org/10.3892/ijo.3.4.645
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Abstract

In tumor immunology, it is more important that tumor cells can escape from the immune system of the host than being able to provoke only a weak reaction from the host. With regard to antigenicity, tumor cells can express only oncodevelopmental antigens which were expressed in the developmental process of normal cells. Tumor cells are essentially self, although their antigenic heterogeneity is evident. Under this premise, immunity against tumor is essentially autoimmunity. Actually, most so-called 'tumor specific antigens' have been demonstrated to be self antigens. Immunotherapy against tumor cells may be based on the overly optimistic premise that autoimmunity is not harmful to the host. However, immunotherapy must face the essential duplicity between autoimmunity and tumor rejection. It is, therefore, hypothesized that autoimmunity is prepared and developed as an inhibition mechanism against retro-differentiation of normal cells but not against tumors. Autoimmunity is a check valve mechanism which inhibits reversion of the developmental process of normal cells as shown in hemolymph protein of larvae.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

MYTH OF TUMOR IMMUNOLOGY (REVIEW)

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Abstract

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