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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 1993 Volume 3 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October 1993 Volume 3 Issue 4

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INHIBITION OF PROLIFERATION, ACTIVATION AND FUNCTION OF HUMAN NATURAL-KILLER-CELLS IN-VITRO BY SECRETED PRODUCTS OF LOVO, A COLORECTAL-CANCER CELL-LINE

  • Authors:
    • DH JOHNSTON
    • PD ALLEN
    • AC NEWLAND
    • NS WILLIAMS

  • View Affiliations / Copyright

    Affiliations: UNIV LONDON LONDON HOSP,COLL MED,DEPT SURG,LONDON E1 2AD,ENGLAND.
  • Pages: 763-768
    |
    Published online on: October 1, 1993
       https://doi.org/10.3892/ijo.3.4.763
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Abstract

It has previously been suggested that some tumours may elaborate substances which can suppress the functional activity of lymphokine activated killer (LAK) cells. We have investigated the effects of secreted products from the colorectal cancer cell line LoVo on the pattern of expression of T lymphocyte subsets and natural killer cell phenotype and activation antigens during in vitro treatment of mixed populations of human peripheral blood mononuclear cells with recombinant human IL-2 (rhIL-2). Tumour cell line products inhibited the proliferation of cells expressing the NK cell antigen CD56 and of cells expressing the CD8 T cell subset antigen. Increased expression of the IL-2 receptor alpha chain component CD25, and the activation associated antigens CD71 and HLA-DR induced by rhIL-2 was inhibited by the presence of tumour cell products. Enhanced cytotoxic activity against standard target. cell lines Daudi and K562 induced by treatment with rhIL-2 was diminished by tumour cell supernatants. These mechanisms may contribute to the resistance of some tumours to immune response modulation treatment regimens which depend upon induction of lymphokine activation responses by rhIL-2.

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Copy and paste a formatted citation
Spandidos Publications style
JOHNSTON D, ALLEN P, NEWLAND A and WILLIAMS N: INHIBITION OF PROLIFERATION, ACTIVATION AND FUNCTION OF HUMAN NATURAL-KILLER-CELLS IN-VITRO BY SECRETED PRODUCTS OF LOVO, A COLORECTAL-CANCER CELL-LINE. Int J Oncol 3: 763-768, 1993.
APA
JOHNSTON, D., ALLEN, P., NEWLAND, A., & WILLIAMS, N. (1993). INHIBITION OF PROLIFERATION, ACTIVATION AND FUNCTION OF HUMAN NATURAL-KILLER-CELLS IN-VITRO BY SECRETED PRODUCTS OF LOVO, A COLORECTAL-CANCER CELL-LINE. International Journal of Oncology, 3, 763-768. https://doi.org/10.3892/ijo.3.4.763
MLA
JOHNSTON, D., ALLEN, P., NEWLAND, A., WILLIAMS, N."INHIBITION OF PROLIFERATION, ACTIVATION AND FUNCTION OF HUMAN NATURAL-KILLER-CELLS IN-VITRO BY SECRETED PRODUCTS OF LOVO, A COLORECTAL-CANCER CELL-LINE". International Journal of Oncology 3.4 (1993): 763-768.
Chicago
JOHNSTON, D., ALLEN, P., NEWLAND, A., WILLIAMS, N."INHIBITION OF PROLIFERATION, ACTIVATION AND FUNCTION OF HUMAN NATURAL-KILLER-CELLS IN-VITRO BY SECRETED PRODUCTS OF LOVO, A COLORECTAL-CANCER CELL-LINE". International Journal of Oncology 3, no. 4 (1993): 763-768. https://doi.org/10.3892/ijo.3.4.763
Copy and paste a formatted citation
x
Spandidos Publications style
JOHNSTON D, ALLEN P, NEWLAND A and WILLIAMS N: INHIBITION OF PROLIFERATION, ACTIVATION AND FUNCTION OF HUMAN NATURAL-KILLER-CELLS IN-VITRO BY SECRETED PRODUCTS OF LOVO, A COLORECTAL-CANCER CELL-LINE. Int J Oncol 3: 763-768, 1993.
APA
JOHNSTON, D., ALLEN, P., NEWLAND, A., & WILLIAMS, N. (1993). INHIBITION OF PROLIFERATION, ACTIVATION AND FUNCTION OF HUMAN NATURAL-KILLER-CELLS IN-VITRO BY SECRETED PRODUCTS OF LOVO, A COLORECTAL-CANCER CELL-LINE. International Journal of Oncology, 3, 763-768. https://doi.org/10.3892/ijo.3.4.763
MLA
JOHNSTON, D., ALLEN, P., NEWLAND, A., WILLIAMS, N."INHIBITION OF PROLIFERATION, ACTIVATION AND FUNCTION OF HUMAN NATURAL-KILLER-CELLS IN-VITRO BY SECRETED PRODUCTS OF LOVO, A COLORECTAL-CANCER CELL-LINE". International Journal of Oncology 3.4 (1993): 763-768.
Chicago
JOHNSTON, D., ALLEN, P., NEWLAND, A., WILLIAMS, N."INHIBITION OF PROLIFERATION, ACTIVATION AND FUNCTION OF HUMAN NATURAL-KILLER-CELLS IN-VITRO BY SECRETED PRODUCTS OF LOVO, A COLORECTAL-CANCER CELL-LINE". International Journal of Oncology 3, no. 4 (1993): 763-768. https://doi.org/10.3892/ijo.3.4.763
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