RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR (RHG-CSF) DOES NOT STIMULATE IN-VIVO TUMOR-GROWTH OF THE HUMAN COLON-CANCER CELL-LINE HTB 38 WHICH IS RESPONSIVE IN-VITRO

  • Authors:
    • M KOENIGSMANN
    • MS TOPP
    • E THIEL
    • WE BERDEL
  • View Affiliations

  • Published online on: December 1, 1993     https://doi.org/10.3892/ijo.3.6.1057
  • Pages: 1057-1059
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Abstract

Haematopoietic growth factors such as human granulocyte colony-stimulating factor (G-CSF) have been shown to stimulate in vitro growth of some human solid tumour cell lines. Among these is the human colorectal adenocarcinoma cell line HTB 38. The in vivo relevance of this finding was tested by xenografting HTB 38 cells intracutaneously into athymic nu/nu BALB/c mice. Recombinant human (rh) G-CSF was administered as a subcutaneous bolus twice daily from day 1 to 14 after tumour transplantation at a dose level of 312 mug/kg/day. Serum levels of rhG-CSF were within the range required for the in vitro effect. However, the cytokine caused no significant growth modulation of the tumour in vivo.

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December 1993
Volume 3 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
KOENIGSMANN M, TOPP M, THIEL E and BERDEL W: RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR (RHG-CSF) DOES NOT STIMULATE IN-VIVO TUMOR-GROWTH OF THE HUMAN COLON-CANCER CELL-LINE HTB 38 WHICH IS RESPONSIVE IN-VITRO. Int J Oncol 3: 1057-1059, 1993
APA
KOENIGSMANN, M., TOPP, M., THIEL, E., & BERDEL, W. (1993). RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR (RHG-CSF) DOES NOT STIMULATE IN-VIVO TUMOR-GROWTH OF THE HUMAN COLON-CANCER CELL-LINE HTB 38 WHICH IS RESPONSIVE IN-VITRO. International Journal of Oncology, 3, 1057-1059. https://doi.org/10.3892/ijo.3.6.1057
MLA
KOENIGSMANN, M., TOPP, M., THIEL, E., BERDEL, W."RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR (RHG-CSF) DOES NOT STIMULATE IN-VIVO TUMOR-GROWTH OF THE HUMAN COLON-CANCER CELL-LINE HTB 38 WHICH IS RESPONSIVE IN-VITRO". International Journal of Oncology 3.6 (1993): 1057-1059.
Chicago
KOENIGSMANN, M., TOPP, M., THIEL, E., BERDEL, W."RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR (RHG-CSF) DOES NOT STIMULATE IN-VIVO TUMOR-GROWTH OF THE HUMAN COLON-CANCER CELL-LINE HTB 38 WHICH IS RESPONSIVE IN-VITRO". International Journal of Oncology 3, no. 6 (1993): 1057-1059. https://doi.org/10.3892/ijo.3.6.1057