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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 1993 Volume 3 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 1993 Volume 3 Issue 6

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CYTOTOXIC ACTIVITY AGAINST RESISTANT HUMAN TUMOR-CELL LINES BY 2 SYNTHETIC DEMETHYLPODOPHYLLOTOXIN DERIVATIVES - A SINGLE STEREOISOMERIC CHANGE PREVENTS CELL-DEATH BY APOPTOSIS

  • Authors:
    • H MORIMOTO
    • JP ROBIN
    • C BROQUET
    • JM MENCIA-HUERTA
    • P BRAQUET
    • B BONAVIDA
  • View Affiliations / Copyright

    Affiliations: UNIV CALIF LOS ANGELES,SCH MED,DEPT MICROBIOL & IMMUNOL,10833 LE CONTE AVE,LOS ANGELES,CA 90024. INST HENRI BEAUFOUR,LE PLESSIS ROBINS,FRANCE.
  • Pages: 1061-1066
    |
    Published online on: December 1, 1993
       https://doi.org/10.3892/ijo.3.6.1061
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Abstract

The podophyllotoxin derivative, etoposide, is currently being used in patients with variant malignant diseases. However, studies show resistance to etoposide develops, and thus new agents to overcome resistance are needed. The present study investigated the cytotoxic properties of two synthetic podophyllotoxin derivatives namely 4-o-butanoyl-4'-demethylepipodophyllotoxin (BEPT) and 4-o-butanoyl-4'-demethylpodophyllotoxin (BDPTN or BN58705). Both BEPT and BDPTN are shown to be cytotoxic against a battery of human tumor cell lines. In comparison to etoposide, the magnitude of cytotoxic activity by BEPT and BDPTN was higher. Further, both compounds were cytotoxic to drug resistant lines and also were able to overcome the etoposide and cross-resistance of an MDR+ cell line. The mechanism of cytotoxicity was also examined. Like etoposide, a topoisomerase II inhibitor and inducer of apoptosis, BEPT mediated its cytotoxic activity by an apoptotic pathway. However, BDPTN did not mediate apoptosis. These findings demonstrate that a simple modification in the stereoisomeric structure results in significant modification in both the cytotoxic patterns and the induction of apoptosis. Further, the findings show that the podophyllotoxin analogs can overcome drug resistance and suggest their possible application in the therapy of resistant tumors.

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Copy and paste a formatted citation
Spandidos Publications style
MORIMOTO H, ROBIN J, BROQUET C, MENCIA-HUERTA J, BRAQUET P and BONAVIDA B: CYTOTOXIC ACTIVITY AGAINST RESISTANT HUMAN TUMOR-CELL LINES BY 2 SYNTHETIC DEMETHYLPODOPHYLLOTOXIN DERIVATIVES - A SINGLE STEREOISOMERIC CHANGE PREVENTS CELL-DEATH BY APOPTOSIS. Int J Oncol 3: 1061-1066, 1993.
APA
MORIMOTO, H., ROBIN, J., BROQUET, C., MENCIA-HUERTA, J., BRAQUET, P., & BONAVIDA, B. (1993). CYTOTOXIC ACTIVITY AGAINST RESISTANT HUMAN TUMOR-CELL LINES BY 2 SYNTHETIC DEMETHYLPODOPHYLLOTOXIN DERIVATIVES - A SINGLE STEREOISOMERIC CHANGE PREVENTS CELL-DEATH BY APOPTOSIS. International Journal of Oncology, 3, 1061-1066. https://doi.org/10.3892/ijo.3.6.1061
MLA
MORIMOTO, H., ROBIN, J., BROQUET, C., MENCIA-HUERTA, J., BRAQUET, P., BONAVIDA, B."CYTOTOXIC ACTIVITY AGAINST RESISTANT HUMAN TUMOR-CELL LINES BY 2 SYNTHETIC DEMETHYLPODOPHYLLOTOXIN DERIVATIVES - A SINGLE STEREOISOMERIC CHANGE PREVENTS CELL-DEATH BY APOPTOSIS". International Journal of Oncology 3.6 (1993): 1061-1066.
Chicago
MORIMOTO, H., ROBIN, J., BROQUET, C., MENCIA-HUERTA, J., BRAQUET, P., BONAVIDA, B."CYTOTOXIC ACTIVITY AGAINST RESISTANT HUMAN TUMOR-CELL LINES BY 2 SYNTHETIC DEMETHYLPODOPHYLLOTOXIN DERIVATIVES - A SINGLE STEREOISOMERIC CHANGE PREVENTS CELL-DEATH BY APOPTOSIS". International Journal of Oncology 3, no. 6 (1993): 1061-1066. https://doi.org/10.3892/ijo.3.6.1061
Copy and paste a formatted citation
x
Spandidos Publications style
MORIMOTO H, ROBIN J, BROQUET C, MENCIA-HUERTA J, BRAQUET P and BONAVIDA B: CYTOTOXIC ACTIVITY AGAINST RESISTANT HUMAN TUMOR-CELL LINES BY 2 SYNTHETIC DEMETHYLPODOPHYLLOTOXIN DERIVATIVES - A SINGLE STEREOISOMERIC CHANGE PREVENTS CELL-DEATH BY APOPTOSIS. Int J Oncol 3: 1061-1066, 1993.
APA
MORIMOTO, H., ROBIN, J., BROQUET, C., MENCIA-HUERTA, J., BRAQUET, P., & BONAVIDA, B. (1993). CYTOTOXIC ACTIVITY AGAINST RESISTANT HUMAN TUMOR-CELL LINES BY 2 SYNTHETIC DEMETHYLPODOPHYLLOTOXIN DERIVATIVES - A SINGLE STEREOISOMERIC CHANGE PREVENTS CELL-DEATH BY APOPTOSIS. International Journal of Oncology, 3, 1061-1066. https://doi.org/10.3892/ijo.3.6.1061
MLA
MORIMOTO, H., ROBIN, J., BROQUET, C., MENCIA-HUERTA, J., BRAQUET, P., BONAVIDA, B."CYTOTOXIC ACTIVITY AGAINST RESISTANT HUMAN TUMOR-CELL LINES BY 2 SYNTHETIC DEMETHYLPODOPHYLLOTOXIN DERIVATIVES - A SINGLE STEREOISOMERIC CHANGE PREVENTS CELL-DEATH BY APOPTOSIS". International Journal of Oncology 3.6 (1993): 1061-1066.
Chicago
MORIMOTO, H., ROBIN, J., BROQUET, C., MENCIA-HUERTA, J., BRAQUET, P., BONAVIDA, B."CYTOTOXIC ACTIVITY AGAINST RESISTANT HUMAN TUMOR-CELL LINES BY 2 SYNTHETIC DEMETHYLPODOPHYLLOTOXIN DERIVATIVES - A SINGLE STEREOISOMERIC CHANGE PREVENTS CELL-DEATH BY APOPTOSIS". International Journal of Oncology 3, no. 6 (1993): 1061-1066. https://doi.org/10.3892/ijo.3.6.1061
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