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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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March 2007 Volume 30 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2007 Volume 30 Issue 3

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Article

IL-3 can not replace GM-CSF in inducing human monocytes to differentiate into Langerhans cells

  • Authors:
    • Tetsunori Shibasaki
    • Naoyuki Katayama
    • Kohshi Ohishi
    • Atsushi Fujieda
    • Fumihiko Monma
    • Kazuhiro Nishi
    • Masahiro Masuya
    • Hiroshi Shiku

  • View Affiliations / Copyright

    Affiliations: Department of Hematology and Oncology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan
  • Pages: 549-555
    |
    Published online on: March 1, 2007
       https://doi.org/10.3892/ijo.30.3.549
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Abstract

Receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) share a common β subunit. We recently reported that GM-CSF acts in concert with transforming growth factor-β1 (TGF-β1) and Notch ligand Delta-1 (Delta-1) to promote the differentiation of human blood monocytes into Langerhans cells. In the present study, we examined whether IL-3, in place of GM-CSF, can induce the development of Langerhans cells from blood monocytes in the presence of TGF-β1 and Delta-1, because the IL-3 receptor α chain was substantially expressed on monocytes. However, the generation of Langerhans cells was not obtained by the combination of IL-3, TGF-β1 and Delta-1, even though GM-CSF and IL-3 exhibited a similar effect with respect to the differentiation of monocytes into macrophages and dendritic cells. The addition of GM-CSF to the culture supplemented with IL-3, TGF-β1 and Delta-1 restored the differentiation of monocytes toward Langerhans cells. A microarray analysis revealed that a number of genes including Langerhans cell markers, E-cadherin and Langerin, were specifically expressed in cells from GM-CSF-containing cultures but not in those from IL-3-containing cultures. These data suggest that IL-3 can not replace GM-CSF to induce the differentiation of human monocytes into Langerhans cells in culture.

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Copy and paste a formatted citation
Spandidos Publications style
Shibasaki T, Katayama N, Ohishi K, Fujieda A, Monma F, Nishi K, Masuya M and Shiku H: IL-3 can not replace GM-CSF in inducing human monocytes to differentiate into Langerhans cells. Int J Oncol 30: 549-555, 2007.
APA
Shibasaki, T., Katayama, N., Ohishi, K., Fujieda, A., Monma, F., Nishi, K. ... Shiku, H. (2007). IL-3 can not replace GM-CSF in inducing human monocytes to differentiate into Langerhans cells. International Journal of Oncology, 30, 549-555. https://doi.org/10.3892/ijo.30.3.549
MLA
Shibasaki, T., Katayama, N., Ohishi, K., Fujieda, A., Monma, F., Nishi, K., Masuya, M., Shiku, H."IL-3 can not replace GM-CSF in inducing human monocytes to differentiate into Langerhans cells". International Journal of Oncology 30.3 (2007): 549-555.
Chicago
Shibasaki, T., Katayama, N., Ohishi, K., Fujieda, A., Monma, F., Nishi, K., Masuya, M., Shiku, H."IL-3 can not replace GM-CSF in inducing human monocytes to differentiate into Langerhans cells". International Journal of Oncology 30, no. 3 (2007): 549-555. https://doi.org/10.3892/ijo.30.3.549
Copy and paste a formatted citation
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Spandidos Publications style
Shibasaki T, Katayama N, Ohishi K, Fujieda A, Monma F, Nishi K, Masuya M and Shiku H: IL-3 can not replace GM-CSF in inducing human monocytes to differentiate into Langerhans cells. Int J Oncol 30: 549-555, 2007.
APA
Shibasaki, T., Katayama, N., Ohishi, K., Fujieda, A., Monma, F., Nishi, K. ... Shiku, H. (2007). IL-3 can not replace GM-CSF in inducing human monocytes to differentiate into Langerhans cells. International Journal of Oncology, 30, 549-555. https://doi.org/10.3892/ijo.30.3.549
MLA
Shibasaki, T., Katayama, N., Ohishi, K., Fujieda, A., Monma, F., Nishi, K., Masuya, M., Shiku, H."IL-3 can not replace GM-CSF in inducing human monocytes to differentiate into Langerhans cells". International Journal of Oncology 30.3 (2007): 549-555.
Chicago
Shibasaki, T., Katayama, N., Ohishi, K., Fujieda, A., Monma, F., Nishi, K., Masuya, M., Shiku, H."IL-3 can not replace GM-CSF in inducing human monocytes to differentiate into Langerhans cells". International Journal of Oncology 30, no. 3 (2007): 549-555. https://doi.org/10.3892/ijo.30.3.549
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