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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2007 Volume 30 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2007 Volume 30 Issue 5

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Article

Characteristics and differentiated mechanism of vascular endothelial cells-like derived from epithelial ovarian cancer cells induced by hypoxia

  • Authors:
    • Liang-Qing Yao
    • You-Ji Feng
    • Jing-Xin Ding
    • Hui-Ming Jing
    • Cong-Jian Xu
    • Si-Feng Chen
    • Ming Su
    • Liang-Hua Yin

  • View Affiliations / Copyright

    Affiliations: Department of Gynecologic Oncology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, P.R. China
  • Pages: 1069-1075
    |
    Published online on: May 1, 2007
       https://doi.org/10.3892/ijo.30.5.1069
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Abstract

A few highly aggressive and malignant tumor cells could acquire identities by turning on genes expressed by endothelial cells and recruit blood vessels to sustain tumor growth. Hypoxia was reported recently to play an essential role in these events. These ‘plastic’ tumor-cell phenotypes and the exact mechanism driving transendothelial differentiation by hypoxia-inducible factor (HIF)-1α is unclear. In this study, epithelial ovarian carcinoma cells were exposed to hypoxia and the tumor cells were transformed into endothelial cells-like (ECs-like). Typical endothelial features such as cell markers and uptaking of acetylated low density lipoprotein were identified constantly. Small interference RNA was used to block the expression of HIF-1α. Analysis revealed that hypoxia promotes transendothelial differentiation through stimulating HIF-1-dependent transcriptional expression of vascular endothelial growth factor (VEGF), VEGF receptor-2 (Flk-1) and P53, and through decreasing HIF-1-independent transcriptional expression of Cyclin D1. These results demonstrate that ECs-like derived from epithelial ovarian cancer cells are similar to endothelial progenitor cells rather than endothelial cells. HIF-1α is crucial but not unique in alternation of tumor cells towards ECs-like.

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Copy and paste a formatted citation
Spandidos Publications style
Yao L, Feng Y, Ding J, Jing H, Xu C, Chen S, Su M and Yin L: Characteristics and differentiated mechanism of vascular endothelial cells-like derived from epithelial ovarian cancer cells induced by hypoxia. Int J Oncol 30: 1069-1075, 2007.
APA
Yao, L., Feng, Y., Ding, J., Jing, H., Xu, C., Chen, S. ... Yin, L. (2007). Characteristics and differentiated mechanism of vascular endothelial cells-like derived from epithelial ovarian cancer cells induced by hypoxia. International Journal of Oncology, 30, 1069-1075. https://doi.org/10.3892/ijo.30.5.1069
MLA
Yao, L., Feng, Y., Ding, J., Jing, H., Xu, C., Chen, S., Su, M., Yin, L."Characteristics and differentiated mechanism of vascular endothelial cells-like derived from epithelial ovarian cancer cells induced by hypoxia". International Journal of Oncology 30.5 (2007): 1069-1075.
Chicago
Yao, L., Feng, Y., Ding, J., Jing, H., Xu, C., Chen, S., Su, M., Yin, L."Characteristics and differentiated mechanism of vascular endothelial cells-like derived from epithelial ovarian cancer cells induced by hypoxia". International Journal of Oncology 30, no. 5 (2007): 1069-1075. https://doi.org/10.3892/ijo.30.5.1069
Copy and paste a formatted citation
x
Spandidos Publications style
Yao L, Feng Y, Ding J, Jing H, Xu C, Chen S, Su M and Yin L: Characteristics and differentiated mechanism of vascular endothelial cells-like derived from epithelial ovarian cancer cells induced by hypoxia. Int J Oncol 30: 1069-1075, 2007.
APA
Yao, L., Feng, Y., Ding, J., Jing, H., Xu, C., Chen, S. ... Yin, L. (2007). Characteristics and differentiated mechanism of vascular endothelial cells-like derived from epithelial ovarian cancer cells induced by hypoxia. International Journal of Oncology, 30, 1069-1075. https://doi.org/10.3892/ijo.30.5.1069
MLA
Yao, L., Feng, Y., Ding, J., Jing, H., Xu, C., Chen, S., Su, M., Yin, L."Characteristics and differentiated mechanism of vascular endothelial cells-like derived from epithelial ovarian cancer cells induced by hypoxia". International Journal of Oncology 30.5 (2007): 1069-1075.
Chicago
Yao, L., Feng, Y., Ding, J., Jing, H., Xu, C., Chen, S., Su, M., Yin, L."Characteristics and differentiated mechanism of vascular endothelial cells-like derived from epithelial ovarian cancer cells induced by hypoxia". International Journal of Oncology 30, no. 5 (2007): 1069-1075. https://doi.org/10.3892/ijo.30.5.1069
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