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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2007 Volume 31 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2007 Volume 31 Issue 1

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Article

Cytogenetic characterisation and proteomic profiling of the Imatinib-resistant cell line KCL22-R

  • Authors:
    • Julia Rosenhahn
    • Anja Weise
    • Susanne Michel
    • Katrin Hennig
    • Isabell Hartmann
    • Jana Schiefner
    • Katrin Schubert
    • Thomas Liehr
    • Ferdinand Von Eggeling
    • Ivan F. Loncarevic

  • View Affiliations / Copyright

    Affiliations: Core Unit Chip Application, Institute of Human Genetics and Anthropology, Jena, Germany
  • Pages: 121-128
    |
    Published online on: July 1, 2007
       https://doi.org/10.3892/ijo.31.1.121
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Abstract

Approximately 30% of chronic myeloid leukemia patients show initially no response to Imatinib, a potent inhibitor of BCR-ABL. This intrinsic resistance may be due to BCR-ABL-independent cell growth. Here we analysed the cytogenetic anomalies and the proteomic profiling in KCL22-S and KCL22-R, two Imatinib-sensitive and -resistant derivative cell lines of KCL22. A tetrasomy 8 and a non-reciprocal translocation +der(6)t(6;13)(p11.1;q12) were found only in KCL22-R as new evolved anomalies. Chromosome der(6)t(6;13) showed four variants differing in the chromatin content of 13q14-13qter including the retinoblastoma gene. Due to these sub-clones, approximately 65-79% of the Imatinib-treated KCL22-R cells showed a disomy and 21-35% a monosomy for 13q14. Imatinib removal reduced the main clone to approximately 20% in the benefit of the monosomic sub-clones. This was accompanied by an increased apoptosis rate and was revertible by Imatinib re-treatment. This effect may be connected with genes located in 13q14-qter. Proteomic profiling of the cell lines performed with ProteinChip technology (SELDI) revealed several differentially expressed proteins (n=45). In summary, we demonstrate here the complex changes on the cytogenetic and proteomic level which could be caused by Imatinib and the resistance resulting from it.

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Copy and paste a formatted citation
Spandidos Publications style
Rosenhahn J, Weise A, Michel S, Hennig K, Hartmann I, Schiefner J, Schubert K, Liehr T, Von Eggeling F, Loncarevic IF, Loncarevic IF, et al: Cytogenetic characterisation and proteomic profiling of the Imatinib-resistant cell line KCL22-R. Int J Oncol 31: 121-128, 2007.
APA
Rosenhahn, J., Weise, A., Michel, S., Hennig, K., Hartmann, I., Schiefner, J. ... Loncarevic, I.F. (2007). Cytogenetic characterisation and proteomic profiling of the Imatinib-resistant cell line KCL22-R. International Journal of Oncology, 31, 121-128. https://doi.org/10.3892/ijo.31.1.121
MLA
Rosenhahn, J., Weise, A., Michel, S., Hennig, K., Hartmann, I., Schiefner, J., Schubert, K., Liehr, T., Von Eggeling, F., Loncarevic, I. F."Cytogenetic characterisation and proteomic profiling of the Imatinib-resistant cell line KCL22-R". International Journal of Oncology 31.1 (2007): 121-128.
Chicago
Rosenhahn, J., Weise, A., Michel, S., Hennig, K., Hartmann, I., Schiefner, J., Schubert, K., Liehr, T., Von Eggeling, F., Loncarevic, I. F."Cytogenetic characterisation and proteomic profiling of the Imatinib-resistant cell line KCL22-R". International Journal of Oncology 31, no. 1 (2007): 121-128. https://doi.org/10.3892/ijo.31.1.121
Copy and paste a formatted citation
x
Spandidos Publications style
Rosenhahn J, Weise A, Michel S, Hennig K, Hartmann I, Schiefner J, Schubert K, Liehr T, Von Eggeling F, Loncarevic IF, Loncarevic IF, et al: Cytogenetic characterisation and proteomic profiling of the Imatinib-resistant cell line KCL22-R. Int J Oncol 31: 121-128, 2007.
APA
Rosenhahn, J., Weise, A., Michel, S., Hennig, K., Hartmann, I., Schiefner, J. ... Loncarevic, I.F. (2007). Cytogenetic characterisation and proteomic profiling of the Imatinib-resistant cell line KCL22-R. International Journal of Oncology, 31, 121-128. https://doi.org/10.3892/ijo.31.1.121
MLA
Rosenhahn, J., Weise, A., Michel, S., Hennig, K., Hartmann, I., Schiefner, J., Schubert, K., Liehr, T., Von Eggeling, F., Loncarevic, I. F."Cytogenetic characterisation and proteomic profiling of the Imatinib-resistant cell line KCL22-R". International Journal of Oncology 31.1 (2007): 121-128.
Chicago
Rosenhahn, J., Weise, A., Michel, S., Hennig, K., Hartmann, I., Schiefner, J., Schubert, K., Liehr, T., Von Eggeling, F., Loncarevic, I. F."Cytogenetic characterisation and proteomic profiling of the Imatinib-resistant cell line KCL22-R". International Journal of Oncology 31, no. 1 (2007): 121-128. https://doi.org/10.3892/ijo.31.1.121
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