Activation of a system A amino acid transporter, ATA1/SLC38A1, in human hepatocellular carcinoma and preneoplastic liver tissues

  • Authors:
    • Nobuo Kondoh
    • Nobuo Imazeki
    • Masaaki Arai
    • Akiyuki Hada
    • Kazuo Hatsuse
    • Hirotaka Matsuo
    • Osamu Matsubara
    • Shuri Ohkura
    • Mikio Yamamoto
  • View Affiliations

  • Published online on: July 1, 2007     https://doi.org/10.3892/ijo.31.1.81
  • Pages: 81-87
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Abstract

The expression of amino acid transporter (AT) mRNAs including A system (ATA1/SNAT1/SLC38A1, ATA2/SNAT2/SLC38A2 and ATA3/SNAT3/SLC38A4), L system (LAT1/SLC7A5 and LAT2/SLC7A8), and y+ (CAT2/SLC7A2) genes, were compared among hepatocellular carcinoma (HCC) and non-cancerous liver cells. Among them the ATA1 mRNA expression was significantly elevated in all HCC cell lines (HepG2, HLF, HuH7 and JHH4) examined compared with normal liver tissue. We further discovered that the expression of ATA1 mRNA was significantly activated in HCC tissues and also elevated in pre-malignant cirrhotic livers from HCC patients, compared with normal livers from non-HCC patients. The ATA1 protein was extensively accumulated in the cytoplasm of pre-malignant liver and most HCCs, while being weak or undetectably low in normal liver tissues. SiRNA-mediated suppression of endogenous ATA1 lowered the viability of HepG2 cells. Thus, the activation of ATA1 confers growth and survival advantages in pre-malignant and malignant liver lesions.

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July 2007
Volume 31 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Kondoh N, Imazeki N, Arai M, Hada A, Hatsuse K, Matsuo H, Matsubara O, Ohkura S and Yamamoto M: Activation of a system A amino acid transporter, ATA1/SLC38A1, in human hepatocellular carcinoma and preneoplastic liver tissues. Int J Oncol 31: 81-87, 2007
APA
Kondoh, N., Imazeki, N., Arai, M., Hada, A., Hatsuse, K., Matsuo, H. ... Yamamoto, M. (2007). Activation of a system A amino acid transporter, ATA1/SLC38A1, in human hepatocellular carcinoma and preneoplastic liver tissues. International Journal of Oncology, 31, 81-87. https://doi.org/10.3892/ijo.31.1.81
MLA
Kondoh, N., Imazeki, N., Arai, M., Hada, A., Hatsuse, K., Matsuo, H., Matsubara, O., Ohkura, S., Yamamoto, M."Activation of a system A amino acid transporter, ATA1/SLC38A1, in human hepatocellular carcinoma and preneoplastic liver tissues". International Journal of Oncology 31.1 (2007): 81-87.
Chicago
Kondoh, N., Imazeki, N., Arai, M., Hada, A., Hatsuse, K., Matsuo, H., Matsubara, O., Ohkura, S., Yamamoto, M."Activation of a system A amino acid transporter, ATA1/SLC38A1, in human hepatocellular carcinoma and preneoplastic liver tissues". International Journal of Oncology 31, no. 1 (2007): 81-87. https://doi.org/10.3892/ijo.31.1.81