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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2007 Volume 31 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2007 Volume 31 Issue 3

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Article

Establishment and characterization of a novel, spontaneously immortalized retinoblastoma cell line with adherent growth

  • Authors:
    • Jeong Hun Kim
    • Jin Hyoung Kim
    • Young Suk Yu
    • Dong Hun Kim
    • Chong Jai Kim
    • Kyu-Won Kim

  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Seoul National University College of Medicine and Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
  • Pages: 585-592
    |
    Published online on: September 1, 2007
       https://doi.org/10.3892/ijo.31.3.585
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Abstract

Retinoblastoma is the most common intraocular cancer of childhood, however, only a few cultured retinoblastoma cell lines are available to date. In the present study, we established a new human retinoblastoma cell line with adherent growth, named SNUOT-Rb1. The SNUOT-Rb1 cell line was established from an eye with retinoblastoma, which was enucleated from a 3-year-old Korean child. SNUOT-Rb1 has morphological and biochemical characteristics common to previous human retinoblastoma cell line, Y79: morphological features of fibroblast- or ganglion-like cells, and biochemical features of expression of glial fibrillary acidic protein and neuron-specific enolase. However, compared to Y79, SNUOT-Rb1 has a unique characteristic of growing in adherence, and the doubling time of SNUOT-Rb1 is shorter than Y79 in adherent or floating growth. In analysis of the tumorigenic potential of SNUOT-Rb1 in nude mice, orthotopic implantation of SNUOT-Rb1 mimics the pattern of local growth of retinoblastoma. In comparative genomic hybridization analysis, we found that SNUOT-Rb1 has significant chromosomal imbalances on chromosome 3, 9, 10, 11, 14, 16, 17, and 22. Therefore, SNUOT-Rb1 could be useful in studying the biological and genetic characteristics of retinoblastoma for insights into the heredity and genetics of childhood cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Kim JH, Kim JH, Yu YS, Kim DH, Kim CJ and Kim K: Establishment and characterization of a novel, spontaneously immortalized retinoblastoma cell line with adherent growth. Int J Oncol 31: 585-592, 2007.
APA
Kim, J.H., Kim, J.H., Yu, Y.S., Kim, D.H., Kim, C.J., & Kim, K. (2007). Establishment and characterization of a novel, spontaneously immortalized retinoblastoma cell line with adherent growth. International Journal of Oncology, 31, 585-592. https://doi.org/10.3892/ijo.31.3.585
MLA
Kim, J. H., Kim, J. H., Yu, Y. S., Kim, D. H., Kim, C. J., Kim, K."Establishment and characterization of a novel, spontaneously immortalized retinoblastoma cell line with adherent growth". International Journal of Oncology 31.3 (2007): 585-592.
Chicago
Kim, J. H., Kim, J. H., Yu, Y. S., Kim, D. H., Kim, C. J., Kim, K."Establishment and characterization of a novel, spontaneously immortalized retinoblastoma cell line with adherent growth". International Journal of Oncology 31, no. 3 (2007): 585-592. https://doi.org/10.3892/ijo.31.3.585
Copy and paste a formatted citation
x
Spandidos Publications style
Kim JH, Kim JH, Yu YS, Kim DH, Kim CJ and Kim K: Establishment and characterization of a novel, spontaneously immortalized retinoblastoma cell line with adherent growth. Int J Oncol 31: 585-592, 2007.
APA
Kim, J.H., Kim, J.H., Yu, Y.S., Kim, D.H., Kim, C.J., & Kim, K. (2007). Establishment and characterization of a novel, spontaneously immortalized retinoblastoma cell line with adherent growth. International Journal of Oncology, 31, 585-592. https://doi.org/10.3892/ijo.31.3.585
MLA
Kim, J. H., Kim, J. H., Yu, Y. S., Kim, D. H., Kim, C. J., Kim, K."Establishment and characterization of a novel, spontaneously immortalized retinoblastoma cell line with adherent growth". International Journal of Oncology 31.3 (2007): 585-592.
Chicago
Kim, J. H., Kim, J. H., Yu, Y. S., Kim, D. H., Kim, C. J., Kim, K."Establishment and characterization of a novel, spontaneously immortalized retinoblastoma cell line with adherent growth". International Journal of Oncology 31, no. 3 (2007): 585-592. https://doi.org/10.3892/ijo.31.3.585
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