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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2007 Volume 31 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2007 Volume 31 Issue 3

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Article

Growth of transgenic RAF-induced lung adenomas is increased in mice with a disrupted PPARβ/δ gene

  • Authors:
    • Sabine Müller-Brüsselbach
    • Schokufe Ebrahimsade
    • Jörg Jäkel
    • Jenny Eckhardt
    • Ulf R. Rapp
    • Jeffrey M. Peters
    • Roland Moll
    • Rolf Müller

  • View Affiliations / Copyright

    Affiliations: Institute of Molecular Biology and Tumor Research (IMT), Philipps University, D-35032 Marburg, Germany
  • Pages: 607-611
    |
    Published online on: September 1, 2007
       https://doi.org/10.3892/ijo.31.3.607
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Abstract

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors with essential functions in regulating lipid metabolism. Both the PPARβ (also referred to as PPARδ) and PPARγ subtype have been reported to either attenuate or potentiate tumorigenesis in a number of different models of intestinal and skin carcinogenesis. In the present study, we have addressed the role of PPARβ and PPARγ in lung tumorigenesis in a transgenic mouse model of RAF-induced lung adenoma using two different strategies: i) crossing with PPARβ null mice, and ii) chronic treatment with the PPARγ agonist rosiglitazone. Histological examination revealed a significant enhancement of tumor growth in mice lacking one or both alleles of Pparb, but no significant effect in response to rosiglitazone. These observations indicate i) that RAF-induced lung tumorigenesis is attenuated in mice with a disrupted Pparb gene, and ii) that chronic PPARγ activation does not affect lung adenoma growth. These results are relevant with respect to the clinical application of drugs modulating the activity of PPARβ or PPARγ.

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Copy and paste a formatted citation
Spandidos Publications style
Müller-Brüsselbach S, Ebrahimsade S, Jäkel J, Eckhardt J, Rapp UR, Peters JM, Moll R and Müller R: Growth of transgenic RAF-induced lung adenomas is increased in mice with a disrupted PPARβ/δ gene. Int J Oncol 31: 607-611, 2007.
APA
Müller-Brüsselbach, S., Ebrahimsade, S., Jäkel, J., Eckhardt, J., Rapp, U.R., Peters, J.M. ... Müller, R. (2007). Growth of transgenic RAF-induced lung adenomas is increased in mice with a disrupted PPARβ/δ gene. International Journal of Oncology, 31, 607-611. https://doi.org/10.3892/ijo.31.3.607
MLA
Müller-Brüsselbach, S., Ebrahimsade, S., Jäkel, J., Eckhardt, J., Rapp, U. R., Peters, J. M., Moll, R., Müller, R."Growth of transgenic RAF-induced lung adenomas is increased in mice with a disrupted PPARβ/δ gene". International Journal of Oncology 31.3 (2007): 607-611.
Chicago
Müller-Brüsselbach, S., Ebrahimsade, S., Jäkel, J., Eckhardt, J., Rapp, U. R., Peters, J. M., Moll, R., Müller, R."Growth of transgenic RAF-induced lung adenomas is increased in mice with a disrupted PPARβ/δ gene". International Journal of Oncology 31, no. 3 (2007): 607-611. https://doi.org/10.3892/ijo.31.3.607
Copy and paste a formatted citation
x
Spandidos Publications style
Müller-Brüsselbach S, Ebrahimsade S, Jäkel J, Eckhardt J, Rapp UR, Peters JM, Moll R and Müller R: Growth of transgenic RAF-induced lung adenomas is increased in mice with a disrupted PPARβ/δ gene. Int J Oncol 31: 607-611, 2007.
APA
Müller-Brüsselbach, S., Ebrahimsade, S., Jäkel, J., Eckhardt, J., Rapp, U.R., Peters, J.M. ... Müller, R. (2007). Growth of transgenic RAF-induced lung adenomas is increased in mice with a disrupted PPARβ/δ gene. International Journal of Oncology, 31, 607-611. https://doi.org/10.3892/ijo.31.3.607
MLA
Müller-Brüsselbach, S., Ebrahimsade, S., Jäkel, J., Eckhardt, J., Rapp, U. R., Peters, J. M., Moll, R., Müller, R."Growth of transgenic RAF-induced lung adenomas is increased in mice with a disrupted PPARβ/δ gene". International Journal of Oncology 31.3 (2007): 607-611.
Chicago
Müller-Brüsselbach, S., Ebrahimsade, S., Jäkel, J., Eckhardt, J., Rapp, U. R., Peters, J. M., Moll, R., Müller, R."Growth of transgenic RAF-induced lung adenomas is increased in mice with a disrupted PPARβ/δ gene". International Journal of Oncology 31, no. 3 (2007): 607-611. https://doi.org/10.3892/ijo.31.3.607
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