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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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September 2007 Volume 31 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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September 2007 Volume 31 Issue 3

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Article

Type I interferon prolongs cell cycle progression via p21WAF1/CIP1 induction in human colon cancer cells

  • Authors:
    • Tomonari Katayama
    • Kazuaki Nakanishi
    • Hiroshi Nishihara
    • Naoya Kamiyama
    • Takahito Nakagawa
    • Toshiya Kamiyama
    • Ken Iseki
    • Shinya Tanaka
    • Satoru Todo

  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan. tomonari@f4.dion.ne.jp
  • Pages: 613-620
    |
    Published online on: September 1, 2007
       https://doi.org/10.3892/ijo.31.3.613
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Abstract

Type I interferon (IFN) was originally identified as an immunomodulatory cytokine because of its antiviral activity. Further characterization of its biological effects revealed a prominent role in the direct control of cell growth and potent immunomodulatory and antiangiogenic actions. IFN-α and IFN-β had both been classified as type I IFN, but differences in their antitumor activities were reported. We confirmed the difference in the antiproliferative activities of IFN-α2b and IFN-β toward HT29 and SW480 cells. IFN treatment was observed to prolong cell cycle progression; in particular, the accumulation of S-phase population was one of the most characteristic changes. The prolongation of S-phase progression and transition into G2/M-phase was suggested to be a crucial action of type I IFN on colon cancer. Additionally, IFN activated the p21 promoter gene and induced p21WAF1/CIP1 expression. Furthermore, the cell cycle prolongation effect of IFN was suppressed when p21 expression was downregulated. Therefore, we confirmed that p21WAF1/CIP1 was a crucial target molecule for the effects of IFN on the cell cycle. Additionally, the ability of p21 induction differed between IFN-α2b and IFN-β and correlated with their inhibitory activities toward cell growth. We conclude that type I IFN prolongs cell cycle progression by p21WAF1/CIP1 induction in human colon cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Katayama T, Nakanishi K, Nishihara H, Kamiyama N, Nakagawa T, Kamiyama T, Iseki K, Tanaka S and Todo S: Type I interferon prolongs cell cycle progression via p21WAF1/CIP1 induction in human colon cancer cells. Int J Oncol 31: 613-620, 2007.
APA
Katayama, T., Nakanishi, K., Nishihara, H., Kamiyama, N., Nakagawa, T., Kamiyama, T. ... Todo, S. (2007). Type I interferon prolongs cell cycle progression via p21WAF1/CIP1 induction in human colon cancer cells. International Journal of Oncology, 31, 613-620. https://doi.org/10.3892/ijo.31.3.613
MLA
Katayama, T., Nakanishi, K., Nishihara, H., Kamiyama, N., Nakagawa, T., Kamiyama, T., Iseki, K., Tanaka, S., Todo, S."Type I interferon prolongs cell cycle progression via p21WAF1/CIP1 induction in human colon cancer cells". International Journal of Oncology 31.3 (2007): 613-620.
Chicago
Katayama, T., Nakanishi, K., Nishihara, H., Kamiyama, N., Nakagawa, T., Kamiyama, T., Iseki, K., Tanaka, S., Todo, S."Type I interferon prolongs cell cycle progression via p21WAF1/CIP1 induction in human colon cancer cells". International Journal of Oncology 31, no. 3 (2007): 613-620. https://doi.org/10.3892/ijo.31.3.613
Copy and paste a formatted citation
x
Spandidos Publications style
Katayama T, Nakanishi K, Nishihara H, Kamiyama N, Nakagawa T, Kamiyama T, Iseki K, Tanaka S and Todo S: Type I interferon prolongs cell cycle progression via p21WAF1/CIP1 induction in human colon cancer cells. Int J Oncol 31: 613-620, 2007.
APA
Katayama, T., Nakanishi, K., Nishihara, H., Kamiyama, N., Nakagawa, T., Kamiyama, T. ... Todo, S. (2007). Type I interferon prolongs cell cycle progression via p21WAF1/CIP1 induction in human colon cancer cells. International Journal of Oncology, 31, 613-620. https://doi.org/10.3892/ijo.31.3.613
MLA
Katayama, T., Nakanishi, K., Nishihara, H., Kamiyama, N., Nakagawa, T., Kamiyama, T., Iseki, K., Tanaka, S., Todo, S."Type I interferon prolongs cell cycle progression via p21WAF1/CIP1 induction in human colon cancer cells". International Journal of Oncology 31.3 (2007): 613-620.
Chicago
Katayama, T., Nakanishi, K., Nishihara, H., Kamiyama, N., Nakagawa, T., Kamiyama, T., Iseki, K., Tanaka, S., Todo, S."Type I interferon prolongs cell cycle progression via p21WAF1/CIP1 induction in human colon cancer cells". International Journal of Oncology 31, no. 3 (2007): 613-620. https://doi.org/10.3892/ijo.31.3.613
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