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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2007 Volume 31 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2007 Volume 31 Issue 5

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Article

Mutation of the p16/CDKN2 gene and loss of heterozygosity in malignant mucosal melanoma and adenoid cystic carcinoma of the head and neck

  • Authors:
    • Norihisa Suzuki
    • Takeshi Onda
    • Nobuharu Yamamoto
    • Akira Katakura
    • Jun-Etsu Mizoe
    • Takahiko Shibahara

  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillo-Facial Surgery, Tokyo Dental College, Mihama-ku, Chiba 261-8502, Japan
  • Pages: 1061-1067
    |
    Published online on: November 1, 2007
       https://doi.org/10.3892/ijo.31.5.1061
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Abstract

The purpose of this study was to investigate the molecular biological characteristics of malignant mucosal melanoma (MMM) and adenoid cystic carcinoma (ACC) of the head and neck. We analyzed the common genetic abnormalities that may help to identify the loci in the genes involved in the development of MMM and ACC of the head and neck by PCR-LOH on chromosomes 1p, 6q, 9p, 10q, 11q, 12q, 17p, and 19q. LOH was observed in 6 of 12 cases of MMM and in 12 of 15 cases of ACC informative for at least one of the loci analyzed. One distinct deleted region was identified at chromosome 9p21. In addition, to identify a possible involvement of p16/CDKN2 PCR-SSCP and auto-DNA sequence analysis were also performed to detect any mutation of the p16/CDKN2. Particularly, 2 missense mutations were detected in codon 225 and 226, both in MMM and ACC. There were mutational hot spots in the p16/CDKN2 gene. These results suggested that mutation of the p16/CDKN2 gene was a common factor in the development of human MMMs and ACCs, while this gene may be correlated with development and/or progression of a subtype and play a role in the oncogenesis of these cancers.

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Copy and paste a formatted citation
Spandidos Publications style
Suzuki N, Onda T, Yamamoto N, Katakura A, Mizoe J and Shibahara T: Mutation of the p16/CDKN2 gene and loss of heterozygosity in malignant mucosal melanoma and adenoid cystic carcinoma of the head and neck. Int J Oncol 31: 1061-1067, 2007.
APA
Suzuki, N., Onda, T., Yamamoto, N., Katakura, A., Mizoe, J., & Shibahara, T. (2007). Mutation of the p16/CDKN2 gene and loss of heterozygosity in malignant mucosal melanoma and adenoid cystic carcinoma of the head and neck. International Journal of Oncology, 31, 1061-1067. https://doi.org/10.3892/ijo.31.5.1061
MLA
Suzuki, N., Onda, T., Yamamoto, N., Katakura, A., Mizoe, J., Shibahara, T."Mutation of the p16/CDKN2 gene and loss of heterozygosity in malignant mucosal melanoma and adenoid cystic carcinoma of the head and neck". International Journal of Oncology 31.5 (2007): 1061-1067.
Chicago
Suzuki, N., Onda, T., Yamamoto, N., Katakura, A., Mizoe, J., Shibahara, T."Mutation of the p16/CDKN2 gene and loss of heterozygosity in malignant mucosal melanoma and adenoid cystic carcinoma of the head and neck". International Journal of Oncology 31, no. 5 (2007): 1061-1067. https://doi.org/10.3892/ijo.31.5.1061
Copy and paste a formatted citation
x
Spandidos Publications style
Suzuki N, Onda T, Yamamoto N, Katakura A, Mizoe J and Shibahara T: Mutation of the p16/CDKN2 gene and loss of heterozygosity in malignant mucosal melanoma and adenoid cystic carcinoma of the head and neck. Int J Oncol 31: 1061-1067, 2007.
APA
Suzuki, N., Onda, T., Yamamoto, N., Katakura, A., Mizoe, J., & Shibahara, T. (2007). Mutation of the p16/CDKN2 gene and loss of heterozygosity in malignant mucosal melanoma and adenoid cystic carcinoma of the head and neck. International Journal of Oncology, 31, 1061-1067. https://doi.org/10.3892/ijo.31.5.1061
MLA
Suzuki, N., Onda, T., Yamamoto, N., Katakura, A., Mizoe, J., Shibahara, T."Mutation of the p16/CDKN2 gene and loss of heterozygosity in malignant mucosal melanoma and adenoid cystic carcinoma of the head and neck". International Journal of Oncology 31.5 (2007): 1061-1067.
Chicago
Suzuki, N., Onda, T., Yamamoto, N., Katakura, A., Mizoe, J., Shibahara, T."Mutation of the p16/CDKN2 gene and loss of heterozygosity in malignant mucosal melanoma and adenoid cystic carcinoma of the head and neck". International Journal of Oncology 31, no. 5 (2007): 1061-1067. https://doi.org/10.3892/ijo.31.5.1061
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