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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2007 Volume 31 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2007 Volume 31 Issue 6

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Article

Ethanol-induced ligand-independent activation of ERα mediated by cyclic AMP/PKA signaling pathway: An in vitro study on MCF-7 breast cancer cells

  • Authors:
    • Nicolas Etique
    • Stephane Flament
    • Julie Lecomte
    • Isabelle Grillier-Vuissoz

  • View Affiliations / Copyright

    Affiliations: EA 3442 Aspects Cellulaires et Moléculaires de la Reproduction et du Développement, Nancy-Université, Université Henri Poincaré, Faculté des Sciences, 54506 Vandoeuvre-lès-Nancy, France
  • Pages: 1509-1518
    |
    Published online on: December 1, 2007
       https://doi.org/10.3892/ijo.31.6.1509
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Abstract

Alcohol consumption is an increased risk factor for hormone-dependent breast cancer but the underlying molecular bases are unknown. Several studies suggest that ethanol could activate the estrogen signaling pathway. We have performed an in vitro study in order to investigate the molecular players involved in this phenomenon. Exposure of MCF-7 breast cancer cells to ethanol induced an increase in the mRNA level of two well known estrogen target genes: progesterone receptor (PR) and pS2. This result was confirmed by an increase in luciferase activity in pEREtkLuc-transfected MCF-7 cells exposed to ethanol. These effects, whose intensity was similar to those of E2, were observed also in steroid-free medium and were inhibited by the antiestrogen ICI 182,780. This suggested a ligand-independent activation of ERα that was confirmed by the absence of ERα proteolysis in ethanol-treated cells. Using PKA inhibitor (H89), the study of phospho-CREB by Western blot and transfection experiments with a CRE-reporter construct demonstrated that PKA was involved in ethanol-induced transcription of ERα target genes. Adenylyl cyclase inhibition impaired the activation of estrogen signaling pathway induced by ethanol. The results obtained in vitro, are discussed in regard to alcohol consumption and relevance to humans.

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Copy and paste a formatted citation
Spandidos Publications style
Etique N, Flament S, Lecomte J and Grillier-Vuissoz I: Ethanol-induced ligand-independent activation of ERα mediated by cyclic AMP/PKA signaling pathway: An in vitro study on MCF-7 breast cancer cells. Int J Oncol 31: 1509-1518, 2007.
APA
Etique, N., Flament, S., Lecomte, J., & Grillier-Vuissoz, I. (2007). Ethanol-induced ligand-independent activation of ERα mediated by cyclic AMP/PKA signaling pathway: An in vitro study on MCF-7 breast cancer cells. International Journal of Oncology, 31, 1509-1518. https://doi.org/10.3892/ijo.31.6.1509
MLA
Etique, N., Flament, S., Lecomte, J., Grillier-Vuissoz, I."Ethanol-induced ligand-independent activation of ERα mediated by cyclic AMP/PKA signaling pathway: An in vitro study on MCF-7 breast cancer cells". International Journal of Oncology 31.6 (2007): 1509-1518.
Chicago
Etique, N., Flament, S., Lecomte, J., Grillier-Vuissoz, I."Ethanol-induced ligand-independent activation of ERα mediated by cyclic AMP/PKA signaling pathway: An in vitro study on MCF-7 breast cancer cells". International Journal of Oncology 31, no. 6 (2007): 1509-1518. https://doi.org/10.3892/ijo.31.6.1509
Copy and paste a formatted citation
x
Spandidos Publications style
Etique N, Flament S, Lecomte J and Grillier-Vuissoz I: Ethanol-induced ligand-independent activation of ERα mediated by cyclic AMP/PKA signaling pathway: An in vitro study on MCF-7 breast cancer cells. Int J Oncol 31: 1509-1518, 2007.
APA
Etique, N., Flament, S., Lecomte, J., & Grillier-Vuissoz, I. (2007). Ethanol-induced ligand-independent activation of ERα mediated by cyclic AMP/PKA signaling pathway: An in vitro study on MCF-7 breast cancer cells. International Journal of Oncology, 31, 1509-1518. https://doi.org/10.3892/ijo.31.6.1509
MLA
Etique, N., Flament, S., Lecomte, J., Grillier-Vuissoz, I."Ethanol-induced ligand-independent activation of ERα mediated by cyclic AMP/PKA signaling pathway: An in vitro study on MCF-7 breast cancer cells". International Journal of Oncology 31.6 (2007): 1509-1518.
Chicago
Etique, N., Flament, S., Lecomte, J., Grillier-Vuissoz, I."Ethanol-induced ligand-independent activation of ERα mediated by cyclic AMP/PKA signaling pathway: An in vitro study on MCF-7 breast cancer cells". International Journal of Oncology 31, no. 6 (2007): 1509-1518. https://doi.org/10.3892/ijo.31.6.1509
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