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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2007 Volume 31 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2007 Volume 31 Issue 6

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Article

Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in susceptibility to histone deacetylase inhibitors

  • Authors:
    • Camilla Stapnes
    • Anita Ryningen
    • Kimberley Hatfield
    • Anne Margrete Øyan
    • Geir Egil Eide
    • Matthias Corbascio
    • Karl-Henning Kalland
    • Bjørn Tore Gjertsen
    • Øystein Bruserud
  • View Affiliations / Copyright

    Affiliations: Institute of Medicine, University of Bergen/Haukeland University Hospital, N-5021 Bergen, Norway. camilla.ingvaldsen.stapnes@helse-bergen.no
  • Pages: 1529-1538
    |
    Published online on: December 1, 2007
       https://doi.org/10.3892/ijo.31.6.1529
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Abstract

Modulation of gene expression through histone deacetylase (HDAC) inhibition is considered a possible therapeutic strategy in acute myeloid leukaemia (AML). In vitro effects and basal gene expression of structurally different HDAC inhibitors were examined. Primary human AML cells were derived from 59 consecutive patients. The HDAC inhibitors valproic acid, PXD101, trichostatin A and sodium butyrate inhibited leukaemic and clonogenic cell proliferation and increased apoptosis in a dose-dependent manner when tested at high concentrations. However, at lower concentrations proliferation increased for a subset of patients. This divergence was also observed in the presence of all-trans retinoic acid, theophylline and decitabine, and in cocultures with bone marrow stromal cells. Levels of IL-1β, IL-6, GM-CSF and TNFα increased. Based on the basal expression of 100 genes the patients with growth enhancement at intermediate HDAC inhibitor concentrations and those without this response were clustered into two mutually exclusive groups. Functional characterization and gene expression analyses identify AML patient subsets that differ in their response to HDAC inhibitors. These observations may explain why HDAC inhibitor therapy affects only a subset of patients.

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Copy and paste a formatted citation
Spandidos Publications style
Stapnes C, Ryningen A, Hatfield K, Øyan AM, Eide GE, Corbascio M, Kalland K, Gjertsen BT and Bruserud Ø: Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in susceptibility to histone deacetylase inhibitors. Int J Oncol 31: 1529-1538, 2007.
APA
Stapnes, C., Ryningen, A., Hatfield, K., Øyan, A.M., Eide, G.E., Corbascio, M. ... Bruserud, Ø. (2007). Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in susceptibility to histone deacetylase inhibitors. International Journal of Oncology, 31, 1529-1538. https://doi.org/10.3892/ijo.31.6.1529
MLA
Stapnes, C., Ryningen, A., Hatfield, K., Øyan, A. M., Eide, G. E., Corbascio, M., Kalland, K., Gjertsen, B. T., Bruserud, Ø."Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in susceptibility to histone deacetylase inhibitors". International Journal of Oncology 31.6 (2007): 1529-1538.
Chicago
Stapnes, C., Ryningen, A., Hatfield, K., Øyan, A. M., Eide, G. E., Corbascio, M., Kalland, K., Gjertsen, B. T., Bruserud, Ø."Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in susceptibility to histone deacetylase inhibitors". International Journal of Oncology 31, no. 6 (2007): 1529-1538. https://doi.org/10.3892/ijo.31.6.1529
Copy and paste a formatted citation
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Spandidos Publications style
Stapnes C, Ryningen A, Hatfield K, Øyan AM, Eide GE, Corbascio M, Kalland K, Gjertsen BT and Bruserud Ø: Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in susceptibility to histone deacetylase inhibitors. Int J Oncol 31: 1529-1538, 2007.
APA
Stapnes, C., Ryningen, A., Hatfield, K., Øyan, A.M., Eide, G.E., Corbascio, M. ... Bruserud, Ø. (2007). Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in susceptibility to histone deacetylase inhibitors. International Journal of Oncology, 31, 1529-1538. https://doi.org/10.3892/ijo.31.6.1529
MLA
Stapnes, C., Ryningen, A., Hatfield, K., Øyan, A. M., Eide, G. E., Corbascio, M., Kalland, K., Gjertsen, B. T., Bruserud, Ø."Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in susceptibility to histone deacetylase inhibitors". International Journal of Oncology 31.6 (2007): 1529-1538.
Chicago
Stapnes, C., Ryningen, A., Hatfield, K., Øyan, A. M., Eide, G. E., Corbascio, M., Kalland, K., Gjertsen, B. T., Bruserud, Ø."Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in susceptibility to histone deacetylase inhibitors". International Journal of Oncology 31, no. 6 (2007): 1529-1538. https://doi.org/10.3892/ijo.31.6.1529
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