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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2008 Volume 32 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2008 Volume 32 Issue 2

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Article

Pyranicin, a non-classical annonaceous acetogenin, is a potent inhibitor of DNA polymerase, topoisomerase and human cancer cell growth

  • Authors:
    • Shunya Takahashi
    • Yuko Yonezawa
    • Akemi Kubota
    • Narihito Ogawa
    • Katsuya Maeda
    • Hiroyuki Koshino
    • Tadashi Nakata
    • Hiromi Yoshida
    • Yoshiyuki Mizushina

  • View Affiliations / Copyright

    Affiliations: RIKEN (The Institute of Physical and Chemical Research), Wako-shi, Saitama, 351-0198, Japan
  • Pages: 451-458
    |
    Published online on: February 1, 2008
       https://doi.org/10.3892/ijo.32.2.451
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Abstract

This report describes the inhibitory activities of the natural and non-natural acetogenins [mucocin (compound 1), jimenezin (compound 2), 19-epi jimenezin (compound 3), muconin (compound 4), pyranicin (compound 5), pyragonicin (compound 6), 10-epi pyragonicin (compound 7), and a γ-lactone (compound 8)], which were synthesized by us, against DNA polymerase (pol), DNA topoisomerase (topo), and human cancer cell growth. Among the compounds tested, compound 5 was revealed to be the strongest inhibitor of the animal pols and human topos tested, and the IC50 values for pols and topos were 2.3-15.8 and 5.0-7.5 µM, respectively. The compound also suppressed human cancer cell (promyelocytic leukemia cell line, HL-60) growth with the same tendency as the inhibition of pols and topos and the LD50 value was 9.4 µM. Compound 5 arrested the cells at G2/M and G1 phases, and prevented the incorporation of thymidine into the cells, indicating that it blocks DNA replication by inhibiting the activity of pols and topos. This compound also induced apoptosis of the cells. Based on these results, the action mode of compound 5 is discussed.

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Copy and paste a formatted citation
Spandidos Publications style
Takahashi S, Yonezawa Y, Kubota A, Ogawa N, Maeda K, Koshino H, Nakata T, Yoshida H and Mizushina Y: Pyranicin, a non-classical annonaceous acetogenin, is a potent inhibitor of DNA polymerase, topoisomerase and human cancer cell growth. Int J Oncol 32: 451-458, 2008.
APA
Takahashi, S., Yonezawa, Y., Kubota, A., Ogawa, N., Maeda, K., Koshino, H. ... Mizushina, Y. (2008). Pyranicin, a non-classical annonaceous acetogenin, is a potent inhibitor of DNA polymerase, topoisomerase and human cancer cell growth. International Journal of Oncology, 32, 451-458. https://doi.org/10.3892/ijo.32.2.451
MLA
Takahashi, S., Yonezawa, Y., Kubota, A., Ogawa, N., Maeda, K., Koshino, H., Nakata, T., Yoshida, H., Mizushina, Y."Pyranicin, a non-classical annonaceous acetogenin, is a potent inhibitor of DNA polymerase, topoisomerase and human cancer cell growth". International Journal of Oncology 32.2 (2008): 451-458.
Chicago
Takahashi, S., Yonezawa, Y., Kubota, A., Ogawa, N., Maeda, K., Koshino, H., Nakata, T., Yoshida, H., Mizushina, Y."Pyranicin, a non-classical annonaceous acetogenin, is a potent inhibitor of DNA polymerase, topoisomerase and human cancer cell growth". International Journal of Oncology 32, no. 2 (2008): 451-458. https://doi.org/10.3892/ijo.32.2.451
Copy and paste a formatted citation
x
Spandidos Publications style
Takahashi S, Yonezawa Y, Kubota A, Ogawa N, Maeda K, Koshino H, Nakata T, Yoshida H and Mizushina Y: Pyranicin, a non-classical annonaceous acetogenin, is a potent inhibitor of DNA polymerase, topoisomerase and human cancer cell growth. Int J Oncol 32: 451-458, 2008.
APA
Takahashi, S., Yonezawa, Y., Kubota, A., Ogawa, N., Maeda, K., Koshino, H. ... Mizushina, Y. (2008). Pyranicin, a non-classical annonaceous acetogenin, is a potent inhibitor of DNA polymerase, topoisomerase and human cancer cell growth. International Journal of Oncology, 32, 451-458. https://doi.org/10.3892/ijo.32.2.451
MLA
Takahashi, S., Yonezawa, Y., Kubota, A., Ogawa, N., Maeda, K., Koshino, H., Nakata, T., Yoshida, H., Mizushina, Y."Pyranicin, a non-classical annonaceous acetogenin, is a potent inhibitor of DNA polymerase, topoisomerase and human cancer cell growth". International Journal of Oncology 32.2 (2008): 451-458.
Chicago
Takahashi, S., Yonezawa, Y., Kubota, A., Ogawa, N., Maeda, K., Koshino, H., Nakata, T., Yoshida, H., Mizushina, Y."Pyranicin, a non-classical annonaceous acetogenin, is a potent inhibitor of DNA polymerase, topoisomerase and human cancer cell growth". International Journal of Oncology 32, no. 2 (2008): 451-458. https://doi.org/10.3892/ijo.32.2.451
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