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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2008 Volume 32 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2008 Volume 32 Issue 2

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Article

The propeptide of cathepsin D increases proliferation, invasion and metastasis of breast cancer cells

  • Authors:
    • Sujata Saraswat Ohri
    • Aruna Vashishta
    • Mary Proctor
    • Martin Fusek
    • Vaclav Vetvicka

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, University of Louisville, Louisville, KY-40202, USA
  • Pages: 491-498
    |
    Published online on: February 1, 2008
       https://doi.org/10.3892/ijo.32.2.491
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Abstract

Expression and secretion of procathepsin D (pCD) increases proliferation, metastasis and progression of breast cancer but the structural moiety by which pCD exerts these effects is still ambiguous. Here, we present data on a series of pCD stable mutants to identify the pCD region that mediates this mitogenic effect. Mutations affecting the region of the activation peptide (AP) were studied together with catalytic and glycosylation mutants. Mitogenic effect was evaluated using in vitro invasion and proliferation assays and in vivo by determining the tumorigenic potential. The catalytic mutants and glycosylation mutants of pCD continued to display enhanced cell proliferation, invasion and tumorigenicity similar to stable transfectants of native pCD, suggesting that neither the proteolytic activity nor the sugar moieties contribute to the mitogenic effect. However, stable transfectants of pCD lacking its AP and with various mutations in the 27-44 amino acid region of AP, failed to show enhanced cell proliferation or invasion in vitro and tumor growth in vivo, establishing the importance of AP region. Our study concludes that the entire 27-44 amino acid region of AP is necessary for the stimulatory actions of pCD on breast cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Ohri SS, Vashishta A, Proctor M, Fusek M and Vetvicka V: The propeptide of cathepsin D increases proliferation, invasion and metastasis of breast cancer cells. Int J Oncol 32: 491-498, 2008.
APA
Ohri, S.S., Vashishta, A., Proctor, M., Fusek, M., & Vetvicka, V. (2008). The propeptide of cathepsin D increases proliferation, invasion and metastasis of breast cancer cells. International Journal of Oncology, 32, 491-498. https://doi.org/10.3892/ijo.32.2.491
MLA
Ohri, S. S., Vashishta, A., Proctor, M., Fusek, M., Vetvicka, V."The propeptide of cathepsin D increases proliferation, invasion and metastasis of breast cancer cells". International Journal of Oncology 32.2 (2008): 491-498.
Chicago
Ohri, S. S., Vashishta, A., Proctor, M., Fusek, M., Vetvicka, V."The propeptide of cathepsin D increases proliferation, invasion and metastasis of breast cancer cells". International Journal of Oncology 32, no. 2 (2008): 491-498. https://doi.org/10.3892/ijo.32.2.491
Copy and paste a formatted citation
x
Spandidos Publications style
Ohri SS, Vashishta A, Proctor M, Fusek M and Vetvicka V: The propeptide of cathepsin D increases proliferation, invasion and metastasis of breast cancer cells. Int J Oncol 32: 491-498, 2008.
APA
Ohri, S.S., Vashishta, A., Proctor, M., Fusek, M., & Vetvicka, V. (2008). The propeptide of cathepsin D increases proliferation, invasion and metastasis of breast cancer cells. International Journal of Oncology, 32, 491-498. https://doi.org/10.3892/ijo.32.2.491
MLA
Ohri, S. S., Vashishta, A., Proctor, M., Fusek, M., Vetvicka, V."The propeptide of cathepsin D increases proliferation, invasion and metastasis of breast cancer cells". International Journal of Oncology 32.2 (2008): 491-498.
Chicago
Ohri, S. S., Vashishta, A., Proctor, M., Fusek, M., Vetvicka, V."The propeptide of cathepsin D increases proliferation, invasion and metastasis of breast cancer cells". International Journal of Oncology 32, no. 2 (2008): 491-498. https://doi.org/10.3892/ijo.32.2.491
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