Expression of keratinocyte growth factor and its receptor in human endometrial cancer in cooperation with steroid hormones

Ishikawa,Atsuko; Kudo,Mitsuhiro; Nakazawa,Nando; Onda,Munehiko; Ishiwata,Toshiyuki; Takeshita,Toshiyuki; Naito,Zenya

doi:10.3892/ijo.32.3.565

March 2008 Volume 32 Issue 3

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March 2008 Volume 32 Issue 3

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Article

Expression of keratinocyte growth factor and its receptor in human endometrial cancer in cooperation with steroid hormones

Authors:
- Atsuko Ishikawa
- Mitsuhiro Kudo
- Nando Nakazawa
- Munehiko Onda
- Toshiyuki Ishiwata
- Toshiyuki Takeshita
- Zenya Naito
View Affiliations / Copyright

Affiliations: Female Reproductive and Developmental Medicine, Graduate School of Medicine, Nippon Medical School, Bunkyo-ku, Tokyo 113-8603, Japan
Pages: 565-574
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Published online on: March 1, 2008

https://doi.org/10.3892/ijo.32.3.565
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Abstract

The keratinocyte factor (KGF) and its receptor (KGFR) are implicated in tissue development and repair. We studied the expression and functions of KGF and KGFR in association with estrogen and progesterone in human endometrial tissues and cells. In non-cancerous human endometrial tissues in the secretory phase, a strong immunoreactivity of KGF in glands, stromal cells, and smooth muscle cells of spiral arteries was detected; however, in proliferative-phase tissues, the immunoreactivity of KGF or KGFR was weak or absent. Most of the 32 endometrioid adenocarcinoma cases showed positive KGF and KGFR stainings (90.6 and 71.9%, respectively). We then studied, using Ishikawa well-differentiated human endometrial cancer cell line that expresses estrogen receptor (ER) and progesterone receptor (PR), the expression of KGF and KGFR in conjunction with estrogen and progesterone, and observed that the KGFR expression of Ishikawa cells was upregulated by estrogen and that this upregulation was markedly enhanced by the coadministration of progesterone. We also observed that KGF administration to cells, with KGFR upregulated expression, stimulated ERK1/2 phosphorylation and cell adhesion to fibronectin. The implications of the hormone-stimulated KGF-KGFR expressions in the regulation of cell behavior associated with human endometrial cancer are discussed.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Expression of keratinocyte growth factor and its receptor in human endometrial cancer in cooperation with steroid hormones

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Abstract

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