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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2008 Volume 32 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2008 Volume 32 Issue 4

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Article

Alleviation of the drug-resistant phenotype in idarubicin and cytosine arabinoside double-resistant acute myeloid leukemia cells by indomethacin

  • Authors:
    • Ju Han Song
    • Seung Hyun Kim
    • Hyeoung-Joon Kim
    • Seung Yong Hwang
    • Tae Sung Kim

  • View Affiliations / Copyright

    Affiliations: School of Life Sciences and Biotechnology, Korea University, Seoul 136-713, Korea
  • Pages: 931-936
    |
    Published online on: April 1, 2008
       https://doi.org/10.3892/ijo.32.4.931
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Abstract

Chemoresistance to anticancer drugs is a major issue in the successful treatment of acute myeloid leukemia (AML). In this study, we developed an AML cell line (AML-2/IDAC) that is resistant to treatment with a combination of idarubicin and cytosine arabinoside (Id/AraC) by chronic exposure for more than 3 months. We then investigated the ability of indomethacin to alleviate the chemoresistance of AML-2/IDAC cells. Treatment with indomethacin alone induced growth arrest, but not the death of AML-2/IDAC cells. However, when AML-2/IDAC cells were treated with combinations of indomethacin and Id/AraC, the cell death and apoptosis rate of AML-2/IDAC cells were significantly increased in a dose- and time-dependent manner. The combined treatment with indomethacin and Id/AraC caused the collapse of the mitochondrial membrane potential and was also demonstrated to enhance the activities of caspase-3 and -8 in AML-2/IDAC cells. Furthermore, indomethacin down-regulated expression of the ABCA3 and MRP1 genes, which were over-expressed in AML-2/IDAC cells. Taken together, the results of this study suggest that indomethacin can be used to increase the therapeutic potential against drug-resistant AML when combined with anti-leukemic drugs.

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Copy and paste a formatted citation
Spandidos Publications style
Song JH, Kim SH, Kim H, Hwang SY and Kim TS: Alleviation of the drug-resistant phenotype in idarubicin and cytosine arabinoside double-resistant acute myeloid leukemia cells by indomethacin. Int J Oncol 32: 931-936, 2008.
APA
Song, J.H., Kim, S.H., Kim, H., Hwang, S.Y., & Kim, T.S. (2008). Alleviation of the drug-resistant phenotype in idarubicin and cytosine arabinoside double-resistant acute myeloid leukemia cells by indomethacin. International Journal of Oncology, 32, 931-936. https://doi.org/10.3892/ijo.32.4.931
MLA
Song, J. H., Kim, S. H., Kim, H., Hwang, S. Y., Kim, T. S."Alleviation of the drug-resistant phenotype in idarubicin and cytosine arabinoside double-resistant acute myeloid leukemia cells by indomethacin". International Journal of Oncology 32.4 (2008): 931-936.
Chicago
Song, J. H., Kim, S. H., Kim, H., Hwang, S. Y., Kim, T. S."Alleviation of the drug-resistant phenotype in idarubicin and cytosine arabinoside double-resistant acute myeloid leukemia cells by indomethacin". International Journal of Oncology 32, no. 4 (2008): 931-936. https://doi.org/10.3892/ijo.32.4.931
Copy and paste a formatted citation
x
Spandidos Publications style
Song JH, Kim SH, Kim H, Hwang SY and Kim TS: Alleviation of the drug-resistant phenotype in idarubicin and cytosine arabinoside double-resistant acute myeloid leukemia cells by indomethacin. Int J Oncol 32: 931-936, 2008.
APA
Song, J.H., Kim, S.H., Kim, H., Hwang, S.Y., & Kim, T.S. (2008). Alleviation of the drug-resistant phenotype in idarubicin and cytosine arabinoside double-resistant acute myeloid leukemia cells by indomethacin. International Journal of Oncology, 32, 931-936. https://doi.org/10.3892/ijo.32.4.931
MLA
Song, J. H., Kim, S. H., Kim, H., Hwang, S. Y., Kim, T. S."Alleviation of the drug-resistant phenotype in idarubicin and cytosine arabinoside double-resistant acute myeloid leukemia cells by indomethacin". International Journal of Oncology 32.4 (2008): 931-936.
Chicago
Song, J. H., Kim, S. H., Kim, H., Hwang, S. Y., Kim, T. S."Alleviation of the drug-resistant phenotype in idarubicin and cytosine arabinoside double-resistant acute myeloid leukemia cells by indomethacin". International Journal of Oncology 32, no. 4 (2008): 931-936. https://doi.org/10.3892/ijo.32.4.931
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