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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2008 Volume 33 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2008 Volume 33 Issue 1

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Article

ERK1/2 activation is required for resveratrol-induced apoptosis in MDA-MB-231 cells

  • Authors:
    • Thanh-Hung Nguyen
    • Fatimah B. Mustafa
    • Shazib Pervaiz
    • Florence S.P. Ng
    • Lina H.K. Lim

  • View Affiliations / Copyright

    Affiliations: Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456
  • Pages: 81-92
    |
    Published online on: July 1, 2008
       https://doi.org/10.3892/ijo.33.1.81
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Abstract

Resveratrol (RSVL), a phytoalexin found in abundance in grapes and other grape-related products, has been shown to be antiproliferative and protective against various types of cancers, including breast cancer. However, the precise underlying mechanisms are not well understood. In this study, we show that treatment with RSVL induces growth inhibition and apoptosis in a highly invasive and metastatic breast cancer cell line MDA-MB-231. Cleavage of caspase-3 and PARP and fragmentation of DNA were observed following exposure to RSVL. Co-treatment with pan-caspase inhibitor completely prevents cell death induced by RSVL. We found that RSVL-induced apoptosis correlates with sustained activation of ERK1/2 and suppression of Bcl-2 expression. Inhibition of ERK1/2 activation by its specific inhibitor or small interfering RNA reverses the effect of RSVL on Bcl-2 suppression and inhibits apoptosis, while overexpression of MEK1, which is directly upstream of both ERK1 and ERK2, enhances apoptosis induced by RSVL. Moreover, ERK1/2 was found to act upstream of caspase-3 to induce apoptosis, while it was not directly involved in caspase-3 cleavage. The other closely related MAPK members, p38 and JNK are not involved in apoptosis induced by RSVL in MDA-MB-231 cells. These results suggest that activation of ERK1/2 is required for RSVL-induced apoptosis in MDA-MB-231 cells.

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Copy and paste a formatted citation
Spandidos Publications style
Nguyen T, Mustafa FB, Pervaiz S, Ng FS and Lim LH: ERK1/2 activation is required for resveratrol-induced apoptosis in MDA-MB-231 cells. Int J Oncol 33: 81-92, 2008.
APA
Nguyen, T., Mustafa, F.B., Pervaiz, S., Ng, F.S., & Lim, L.H. (2008). ERK1/2 activation is required for resveratrol-induced apoptosis in MDA-MB-231 cells. International Journal of Oncology, 33, 81-92. https://doi.org/10.3892/ijo.33.1.81
MLA
Nguyen, T., Mustafa, F. B., Pervaiz, S., Ng, F. S., Lim, L. H."ERK1/2 activation is required for resveratrol-induced apoptosis in MDA-MB-231 cells". International Journal of Oncology 33.1 (2008): 81-92.
Chicago
Nguyen, T., Mustafa, F. B., Pervaiz, S., Ng, F. S., Lim, L. H."ERK1/2 activation is required for resveratrol-induced apoptosis in MDA-MB-231 cells". International Journal of Oncology 33, no. 1 (2008): 81-92. https://doi.org/10.3892/ijo.33.1.81
Copy and paste a formatted citation
x
Spandidos Publications style
Nguyen T, Mustafa FB, Pervaiz S, Ng FS and Lim LH: ERK1/2 activation is required for resveratrol-induced apoptosis in MDA-MB-231 cells. Int J Oncol 33: 81-92, 2008.
APA
Nguyen, T., Mustafa, F.B., Pervaiz, S., Ng, F.S., & Lim, L.H. (2008). ERK1/2 activation is required for resveratrol-induced apoptosis in MDA-MB-231 cells. International Journal of Oncology, 33, 81-92. https://doi.org/10.3892/ijo.33.1.81
MLA
Nguyen, T., Mustafa, F. B., Pervaiz, S., Ng, F. S., Lim, L. H."ERK1/2 activation is required for resveratrol-induced apoptosis in MDA-MB-231 cells". International Journal of Oncology 33.1 (2008): 81-92.
Chicago
Nguyen, T., Mustafa, F. B., Pervaiz, S., Ng, F. S., Lim, L. H."ERK1/2 activation is required for resveratrol-induced apoptosis in MDA-MB-231 cells". International Journal of Oncology 33, no. 1 (2008): 81-92. https://doi.org/10.3892/ijo.33.1.81
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